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Tobacco and Alcohol Use Behaviors

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Book cover Handbook of Genomics and the Family

Part of the book series: Issues in Clinical Child Psychology ((ICCP))

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Abstract

Substance use disorders (abuse and dependence as defined by the DSM-IV) are common; considering all drug categories nicotine dependence and alcohol dependence are generally the most prevalent. These disorders often cluster within individuals and within families, are the source of familial problems and serious morbidity and mortality, and exact great costs from society. Although evidence-based treatments of substance use disorders exist, the often chronic relapsing–remitting nature of these problems underscores the importance of research that seeks to better understand the biological (as well as social) contributions to risk for these disorders. Genetic studies offer one such approach and this chapter reviews much of that body of work.

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References

  • Agrawal, A., Edenberg, H. J., Foroud, T., Bierut, L. J., Dunne, G., Hinrichs, A. L., et al. (2006). Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behavior Genetics, 36(5), 640–650.

    PubMed  Google Scholar 

  • Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., et al. (2008). Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nature Genetics, 40, 616–622.

    PubMed  Google Scholar 

  • Anton, R. F., Oroszi, G., O’Malley, S., Couper, D., Swift, R., Pettinati, H., et al. (2008). An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Archives of General Psychiatry, 65(2), 135–144.

    PubMed  Google Scholar 

  • Bechara, A. (2001). Neurobiology of decision-making: Risk and reward. Seminars in Clinical Neuropsychiatry, 6(3), 205–216.

    PubMed  Google Scholar 

  • Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience, 8(11), 1458–1463.

    PubMed  Google Scholar 

  • Berrettini, W., Yuan, X., Tozzi, F., Song, K., Francks, C., Chilcoat, H., et al. (2008). Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Molecular Psychiatry, 13(4), 368–373.

    PubMed  Google Scholar 

  • Bettler, B., Kaupmann, K., Mosbacher, J., & Gassmann, M. (2004). Molecular structure and physiological functions of GABA(B) receptors. Physiological Reviews, 84(3), 835–867.

    PubMed  Google Scholar 

  • Bierut, L. J., Madden, P. A., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O. F., et al. (2007). Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics, 16(1), 24–35.

    PubMed  Google Scholar 

  • Boehm, S. L., II, Ponomarev, I., Jennings, A. W., Whiting, P. J., Rosahl, T. W., Garrett, E. M., et al. (2004). Gamma-Aminobutyric acid A receptor subunit mutant mice: New perspectives on alcohol actions. Biochemical Pharmacology, 68(8), 1581–1602.

    PubMed  Google Scholar 

  • Cadoret, R. J., Cain, C. A., & Grove, W. M. (1980). Development of alcoholism in adoptees raised apart from alcoholic biologic relatives. Archives in Genetic Psychiatry, 37(5), 561–563.

    Google Scholar 

  • Chebib, M. (2004). GABAC receptor ion channels. Clinical and Experimental Pharmacology and Physiology, 31(11), 800–804.

    PubMed  Google Scholar 

  • Cloninger, C. R., Bohman, M., & Sigvardsson, S. (1981). Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Archives of Genetic Psychiatry, 38(8), 861–868.

    Google Scholar 

  • Conway, K. P., Compton, W., Stinson, F. S., & Grant, B. F. (2006). Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry, 67(2), 247–257.

    PubMed  Google Scholar 

  • Coors, M. E., & Raymond, K. M. (2009). Substance use disorder genetic research: Investigators and participants grapple with the ethical issues. Psychiatric Genetics, 19(2), 83–90.

    Google Scholar 

  • Cotton, N. S. (1979). The familial incidence of alcoholism: A review. Journal of Studies on Alcohol, 40(1), 89–116.

    PubMed  Google Scholar 

  • Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., & Kranzler, H. R. (2004). Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 129(1), 104–109.

    Google Scholar 

  • Covault, J., Gelernter, J., Jensen, K., Anton, R., & Kranzler, H. R. (2007). Markers in the 5’-Region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 Gene. Neuropsychopharmacology, 33(4), 837–848.

    PubMed  Google Scholar 

  • Crabb, D. W., Edenberg, H. J., Bosron, W. F., & Li, T. K. (1989). Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. Journal of Clinical Investigation, 83(1), 314–316.

    PubMed  Google Scholar 

  • Crowley, T. J., Raymond, K. M., Mikulich-Gilbertson, S. K., Thompson, L. L., & Lejuez, C. W. (2006). A risk-taking “set” in a novel task among adolescents with serious conduct and substance problems. Journal of the American Academy of Child and Adolescent Psychiatry, 45(2), 175–183.

    PubMed  Google Scholar 

  • Dahl, R. E. (2001). Affect regulation, brain development, and behavioral/emotional health in adolescence. CNS Spectrums, 6(1), 60–72.

    PubMed  Google Scholar 

  • Dani, J. A., & Bertrand, D. (2007). Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annual Review of Pharmacology and Toxicology, 47, 699–729.

    PubMed  Google Scholar 

  • Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the evolution of the GABA(A) receptor gene family. Cellular and Molecular Neurobiology, 25(3–4), 607–624.

    PubMed  Google Scholar 

  • Dean, M. (2003). Approaches to identify genes for complex human diseases: Lessons from Mendelian disorders. Hum Mutation, 22(4), 261–274.

    Google Scholar 

  • Deneris, E. S., Boulter, J., Swanson, L. W., Patrick, J., & Heinemann, S. (1989). Beta 3: A new member of nicotinic acetylcholine receptor gene family is expressed in brain. Journal of Biological Chemistry, 264(11), 6268–6272.

    PubMed  Google Scholar 

  • Edenberg, H. J. (2002). The collaborative study on the genetics of alcoholism: An update. Alcohol Research and Health, 26(3), 214–218.

    PubMed  Google Scholar 

  • Edenberg, H. J. (2007). The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Research and Health, 30(1), 5–13.

    PubMed  Google Scholar 

  • Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., et al. (2004). Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. American Journal of Human Genetics, 74(4), 705–714.

    PubMed  Google Scholar 

  • Edenberg, H. J., Xuei, X., Chen, H. J., Tian, H., Wetherill, L. F., Dick, D. M., et al. (2006). Association of alcohol dehydrogenase genes with alcohol dependence: A comprehensive analysis. Human Molecular Genetics, 15(9), 1539–1549.

    PubMed  Google Scholar 

  • Ehlers, C. L. (2007). Variations in ADH and ALDH in Southwest California Indians. Alcohol Research and Health, 30(1), 14–17.

    PubMed  Google Scholar 

  • Ehlers, C. L., & Wilhelmsen, K. C. (2005). Genomic scan for alcohol craving in Mission Indians. Psychiatric Genetics, 15(1), 71–75.

    PubMed  Google Scholar 

  • Ehringer, M. A., Clegg, H. V., Collins, A. C., Corley, R. P., Crowley, T., Hewitt, J., et al. (2007). Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B(5), 596–604.

    Google Scholar 

  • Eng, M. Y., Luczak, S. E., & Wall, T. L. (2007). ALDH2, ADH1B, and ADH1C genotypes in Asians: A literature review. Alcohol Research and Health, 30(1), 22–27.

    PubMed  Google Scholar 

  • Falk, D. E., Yi, H. Y., & Hiller-Sturmhofel, S. (2006). An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Research and Health, 29(3), 162–171.

    PubMed  Google Scholar 

  • Faraone, S. V., Su, J., Taylor, L., Wilcox, M., Van Eerdewegh, P., & Tsuang, M. T. (2004). A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. Human Heredity, 57(2), 59–68.

    PubMed  Google Scholar 

  • Fehr, C., Sander, T., Tadic, A., Lenzen, K. P., Anghelescu, I., Klawe, C., et al. (2006). Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatric Genetics, 16(1), 9–17.

    PubMed  Google Scholar 

  • Feng, Y., Niu, T., Xing, H., Xu, X., Chen, C., Peng, S., et al. (2004). A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. American Journal of Human Genetics, 75(1), 112–121.

    PubMed  Google Scholar 

  • Field, M., Christiansen, P., Cole, J., & Goudie, A. (2007). Delay discounting and the alcohol Stroop in heavy drinking adolescents. Addiction, 102(4), 579–586.

    PubMed  Google Scholar 

  • Foroud, T., Edenberg, H. J., Goate, A., Rice, J., Flury, L., Koller, D. L., et al. (2000). Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping. Alcoholism: Clinical and Experimental Research, 24(7), 933–945.

    Google Scholar 

  • Gault, J., Hopkins, J., Berger, R., Drebing, C., Logel, J., Walton, C., et al. (2003). Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. American Journal of Medical Genetics, 123B(1), 39–49.

    PubMed  Google Scholar 

  • Gelernter, J., Liu, X., Hesselbrock, V., Page, G. P., Goddard, A., & Zhang, H. (2004). Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 128(1), 94–101.

    Google Scholar 

  • Gelernter, J., Panhuysen, C., Weiss, R., Brady, K., Poling, J., Krauthammer, M., et al. (2007). Genomewide linkage scan for nicotine dependence: Identification of a chromosome 5 risk locus. Biological Psychiatry, 61(1), 119–126.

    PubMed  Google Scholar 

  • Goldman, D., Brown, G. L., Albaugh, B., Robin, R., Goodson, S., Trunzo, M., et al. (1993). DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcoholism: Clinical and Experimental Research, 17(2), 199–204.

    Google Scholar 

  • Goldstein, R. B., Dawson, D. A., Saha, T. D., Ruan, W. J., Compton, W. M., & Grant, B. F. (2007). Antisocial behavioral syndromes and DSM-IV alcohol use disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcoholism: Clinical and Experimental Research, 31(5), 814–828.

    Google Scholar 

  • Gotti, C., Moretti, M., Gaimarri, A., Zanardi, A., Clementi, F., & Zoli, M. (2007). Heterogeneity and complexity of native brain nicotinic receptors. Biochemical Pharmacology, 74(8), 1102–1111.

    PubMed  Google Scholar 

  • Gotti, C., Zoli, M., & Clementi, F. (2006). Brain nicotinic acetylcholine receptors: Native subtypes and their relevance. Trends in Pharmacological Sciences, 27(9), 482–491.

    PubMed  Google Scholar 

  • Grant, B. F., Hasin, D. S., Chou, S. P., Stinson, F. S., & Dawson, D. A. (2004). Nicotine dependence and psychiatric disorders in the United States: Results from the national epidemiologic survey on alcohol and related conditions. Archives of General Psychiatry, 61(11), 1107–1115.

    PubMed  Google Scholar 

  • Grant, B. F., Hasin, D. S., Stinson, F. S., Dawson, D. A., June Ruan, W., Goldstein, R. B., et al. (2005). Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychological Medicine, 35(12), 1747–1759.

    PubMed  Google Scholar 

  • Green, J. H. (2007). Fetal alcohol spectrum disorders: Understanding the effects of prenatal alcohol exposure and supporting students. Journal of School Health, 77(3), 103–108.

    PubMed  Google Scholar 

  • Greenbaum, L., Kanyas, K., Karni, O., Merbl, Y., Olender, T., Horowitz, A., et al. (2006). Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. Molecular Psychiatry, 11(3), 312–322.

    PubMed  Google Scholar 

  • Grimm, D. (2008). Public health. Staggering toward a global strategy on alcohol abuse. Science, 320(5878), 862–863.

    PubMed  Google Scholar 

  • Grucza, R. A., & Bierut, L. J. (2006). Co-occurring risk factors for alcohol dependence and habitual smoking: Update on findings from the Collaborative Study on the Genetics of Alcoholism. Alcohol Research and Health, 29(3), 172–178.

    PubMed  Google Scholar 

  • Grucza, R. A., Wang, J. C., Stitzel, J. A., Hinrichs, A. L., Saccone, S. F., Saccone, N. L., et al. (2008). A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biological Psychiatry, 64(11), 922–929.

    PubMed  Google Scholar 

  • Harwood, H. J., Fountain, D., & Fountain, G. (1999). Economic cost of alcohol and drug abuse in the United States, 1992: A report. Addiction, 94(5), 631–635.

    PubMed  Google Scholar 

  • Heath, A. C., Bucholz, K. K., Madden, P. A., Dinwiddie, S. H., Slutske, W. S., Bierut, L. J., et al. (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in women and men. Psychological Medicine, 27(6), 1381–1396.

    PubMed  Google Scholar 

  • Heath, A. C., Madden, P. A., & Martin, N. G. (1998). Statistical methods in genetic research on smoking. Statistic Methods in Medical Research, 7(2), 165–186.

    Google Scholar 

  • Heitjan, D. F., Asch, D. A., Ray, R., Rukstalis, M., Patterson, F., & Lerman, C. (2008). Cost-effectiveness of pharmacogenetic testing to tailor smoking-cessation treatment. Pharmacogenomics Journal, 8(6), 391–399.

    PubMed  Google Scholar 

  • Hettema, J. M., Corey, L. A., & Kendler, K. S. (1999). A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins. Drug and Alcohol Dependence, 57(1), 69–78.

    PubMed  Google Scholar 

  • Hoft, N. R., Corley, R. P., McQueen, M. B., Schlaepfer, I. R., Huizinga, D., & Ehringer, M. A. (2008). Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology, 34(3), 698–706.

    PubMed  Google Scholar 

  • Hopfer, C. J., Stallings, M. C., & Hewitt, J. K. (2001). Common genetic and environmental vulnerability for alcohol and tobacco use in a volunteer sample of older female twins. Journal of Studies on Alcohol, 62(6), 717–723.

    PubMed  Google Scholar 

  • Hrubec, Z., & Omenn, G. S. (1981). Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcoholism: Clinical and Experimental Research, 5(2), 207–215.

    Google Scholar 

  • Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., et al. (2008). A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature, 452(7187), 633–637.

    PubMed  Google Scholar 

  • Hutchison, K. E., Allen, D. L., Filbey, F. M., Jepson, C., Lerman, C., Benowitz, N. L., et al. (2007). CHRNA4 and tobacco dependence: From gene regulation to treatment outcome. Archives in General Psychiatry, 64(9), 1078–1086.

    Google Scholar 

  • Johnson, C., Drgon, T., Liu, Q. R., Walther, D., Edenberg, H., Rice, J., et al. (2006). Pooled association genome scanning for alcohol dependence using 104,268 SNPs: Validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141(8), 844–853.

    Google Scholar 

  • Johnson, J. L., & Leff, M. (1999). Children of substance abusers: Overview of research findings. Pediatrics, 103(5 Pt 2), 1085–1099.

    PubMed  Google Scholar 

  • Kaprio, J., Koskenvuo, M., Langinvainio, H., Romanov, K., Sarna, S., & Rose, R. J. (1987). Genetic influences on use and abuse of alcohol: A study of 5638 adult Finnish twin brothers. Alcoholism: Clinical and Experimental Research, 11(4), 349–356.

    Google Scholar 

  • Kim, S. A., Kim, J. W., Song, J. Y., Park, S., Lee, H. J., & Chung, J. H. (2004). Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol, 34(2–3), 115–120.

    PubMed  Google Scholar 

  • Konnopka, A., & Konig, H. H. (2007). Direct and indirect costs attributable to alcohol consumption in Germany. Pharmacoeconomics, 25(7), 605–618.

    PubMed  Google Scholar 

  • Krystal, J. H., Staley, J., Mason, G., Petrakis, I. L., Kaufman, J., Harris, R. A., et al. (2006). Gamma-aminobutyric acid type A receptors and alcoholism: Intoxication, dependence, vulnerability, and treatment. Archives of General Psychiatry, 63(9), 957–968.

    PubMed  Google Scholar 

  • Laird, N. M., & Lange, C. (2006). Family-based designs in the age of large-scale gene-association studies. Nature Reviews Genetics, 7(5), 385–394.

    PubMed  Google Scholar 

  • Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., et al. (2005). Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcoholism: Clinical and Experimental Research, 29(4), 493–498.

    Google Scholar 

  • Lappalainen, J., Long, J. C., Eggert, M., Ozaki, N., Robin, R. W., Brown, G. L., et al. (1998). Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Archives of General Psychiatry, 55(11), 989–994.

    PubMed  Google Scholar 

  • Le Foll, B., & George, T. P. (2007). Treatment of tobacco dependence: Integrating recent progress into practice. Canadian Medical Association Journal, 177(11), 1373–1380.

    PubMed  Google Scholar 

  • Leonard, K. E., & Eiden, R. D. (2007). Marital and family processes in the context of alcohol use and alcohol disorders. Annual Review of Clinical Psychology, 3, 285–310.

    PubMed  Google Scholar 

  • Leonard, S., Gault, J., Hopkins, J., Logel, J., Vianzon, R., Short, M., et al. (2002). Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in Schizophrenia. Archives of General Psychiatry, 59(12), 1085–1096.

    PubMed  Google Scholar 

  • Li, T. K. (2000). Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. Journal of Studies in Alcohol, 61(1), 5–12.

    Google Scholar 

  • Li, M. D., Beuten, J., Ma, J. Z., Payne, T. J., Lou, X. Y., Garcia, V., et al. (2005). Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Human Molecular Genetics, 14(9), 1211–1219.

    PubMed  Google Scholar 

  • Li, T. K., Hewitt, B. G., & Grant, B. F. (2004). Alcohol use disorders and mood disorders: A National Institute on Alcohol Abuse and Alcoholism perspective. Biological Psychiatry, 56(10), 718–720.

    PubMed  Google Scholar 

  • Li, M. D., Ma, J. Z., Payne, T. J., Lou, X. Y., Zhang, D., Dupont, R. T., et al. (2008). Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. Mol Psychiatry, 13, 407–416.

    PubMed  Google Scholar 

  • Luczak, S. E., Glatt, S. J., & Wall, T. L. (2006). Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. Psychology Bulletin, 132(4), 607–621.

    Google Scholar 

  • Lueders, K. K., Hu, S., McHugh, L., Myakishev, M. V., Sirota, L. A., & Hamer, D. H. (2002). Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). Nicotine and Tobacco Research, 4(1), 115–125.

    PubMed  Google Scholar 

  • Luo, X., Kranzler, H. R., Zuo, L., Wang, S., Schork, N. J., & Gelernter, J. (2006). Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: Multiple significant associations with alcohol dependence. American Journal of Human Genetics, 78(6), 973–987.

    PubMed  Google Scholar 

  • Madden, P. A., Heath, A. C., & Martin, N. G. (1997). Smoking and intoxication after alcohol challenge in women and men: Genetic influences. Alcoholism: Clinical and Experimental Research, 21(9), 1732–1741.

    Google Scholar 

  • McDonough, J., & Deneris, E. (1997). Beta43Ęą: An enhancer displaying neural-restricted activity is located in the 3Ęą-untranslated exon of the rat nicotinic acetylcholine receptor beta4 gene. Journal of Neuroscience, 17(7), 2273–2283.

    PubMed  Google Scholar 

  • Mehta, A. K., & Ticku, M. K. (1999). An update on GABAA receptors. Brain Research Reviews, 29(2–3), 196–217.

    PubMed  Google Scholar 

  • Mokdad, A. H., Marks, J. S., Stroup, D. F., & Gerberding, J. L. (2004). Actual causes of death in the United States, 2000. JAMA, 291(10), 1238–1245.

    PubMed  Google Scholar 

  • Neale, B. M., & Purcell, S. (2008). The positives, protocols, and perils of genome-wide association. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(7), 1288–1294.

    Google Scholar 

  • Ocaranza, P., Quintanilla, M. E., Tampier, L., Karahanian, E., Sapag, A., & Israel, Y. (2008). Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Alcoholism: Clinical and Experimental Research, 32(1), 52–57.

    Google Scholar 

  • Olsen, R. W., Hanchar, H. J., Meera, P., & Wallner, M. (2007). GABAA receptor subtypes: The “one glass of wine” receptors. Alcohol, 41(3), 201–209.

    PubMed  Google Scholar 

  • O’Neill, S. C., Luta, G., Peshkin, B. N., Abraham, A., Walker, L. R., & Tercyak, K. P. (2008). Adolescent medical providers’ willingness to recommend genetic susceptibility testing for nicotine addiction and lung cancer risk to adolescents. Journal of Pediatric Psychology, 34(6), 617–626.

    PubMed  Google Scholar 

  • Osier, M., Pakstis, A. J., Kidd, J. R., Lee, J. F., Yin, S. J., Ko, H. C., et al. (1999). Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. American Journal of Human Genetics, 64(4), 1147–1157.

    PubMed  Google Scholar 

  • Pierucci-Lagha, A., Covault, J., Feinn, R., Nellissery, M., Hernandez-Avila, C., Oncken, C., et al. (2005). GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology, 30(6), 1193–1203.

    PubMed  Google Scholar 

  • Rehm, J., Gnam, W., Popova, S., Baliunas, D., Brochu, S., Fischer, B., et al. (2007). The costs of alcohol, illegal drugs, and tobacco in Canada, 2002. Journal of Studies on Alcohol and Drugs, 68(6), 886–895.

    PubMed  Google Scholar 

  • Reich, T., Edenberg, H. J., Goate, A., Williams, J. T., Rice, J. P., Van Eerdewegh, P., et al. (1998). Genome-wide search for genes affecting the risk for alcohol dependence. American Journal of Medical Genetics, 81(3), 207–215.

    PubMed  Google Scholar 

  • Risch, N. J. (2000). Searching for genetic determinants in the new millennium. Nature, 405(6788), 847–856.

    PubMed  Google Scholar 

  • Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G. A., Konvicka, K., Madden, P. A., et al. (2007). Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Human Molecular Genetics, 16(1), 36–49.

    PubMed  Google Scholar 

  • Saccone, N., Saccone, S., Hinrichs, A., Stitzel, J., Duan, W., Pergadia, M., et al. (in press). Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B(4), 453–466.

    Google Scholar 

  • Schlaepfer, I. R., Hoft, N. R., Collins, A. C., Corley, R. P., Hewitt, J. K., Hopfer, C. J., et al. (2008). The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biological Psychiatry, 63(11), 1039–1046.

    PubMed  Google Scholar 

  • Schuckit, M. A. (1999). New findings in the genetics of alcoholism. JAMA, 281(20), 1875–1876.

    PubMed  Google Scholar 

  • Schuckit, M. A., & Smith, T. L. (1996). An 8-year follow-up of 450 sons of alcoholic and control subjects. Archive of General Psychiatry, 53(3), 202–210.

    Google Scholar 

  • Schuckit, M. A., & Smith, T. L. (2000). The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. Journal of Studies in Alcohol, 61(6), 827–835.

    Google Scholar 

  • Schuckit, M. A., Smith, T. L., Kalmijn, J., Tsuang, J., Hesselbrock, V., & Bucholz, K. (2000). Response to alcohol in daughters of alcoholics: A pilot study and a comparison with sons of alcoholics. Alcohol and Alcoholism, 35(3), 242–248.

    PubMed  Google Scholar 

  • Schuckit, M. A., Smith, T. L., & Tipp, J. E. (1997). The Self-Rating of the Effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism. Addiction, 92(8), 979–988.

    PubMed  Google Scholar 

  • Shenassa, E. D., McCaffery, J. M., Swan, G. E., Khroyan, T. V., Shakib, S., Lerman, C., et al. (2003). Intergenerational transmission of tobacco use and dependence: A transdisciplinary perspective. Nicotine and Tobacco Research, 5(Suppl 1), S55–S69.

    PubMed  Google Scholar 

  • Shields, A., Lerman, C., & Sullivan, P. (2004). Translating emerging research on the genetics of smoking into clinical practice: Ethical and social considerations. Nicotine and Tobacco Research, 6(4), 675–688.

    PubMed  Google Scholar 

  • Shields, A. E., Levy, D. E., Blumenthal, D., Currivan, D., McGinn-Shapiro, M., Weiss, K. B., et al. (2008). Primary care physicians’ willingness to offer a new genetic test to tailor smoking treatment, according to test characteristics. Nicotine and Tobacco Research, 10(6), 1037–1045.

    PubMed  Google Scholar 

  • Sigvardsson, S., Bohman, M., & Cloninger, C. R. (1996). Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis. Archives in General Psychiatry, 53(8), 681–687.

    Google Scholar 

  • Silverman, M. A., Neale, M. C., Sullivan, P. F., Harris-Kerr, C., Wormley, B., Sadek, H., et al. (2000). Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. American Journal of Medical Genetics, 96(5), 646–653.

    PubMed  Google Scholar 

  • Stallings, M. C., Corley, R. P., Hewitt, J. K., Krauter, K. S., Lessem, J. M., Mikulich, S. K., et al. (2003). A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. Drug and Alcohol Dependence, 70(3), 295–307.

    PubMed  Google Scholar 

  • Stinson, F. S., Grant, B. F., Dawson, D. A., Ruan, W. J., Huang, B., & Saha, T. (2005). Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug and Alcohol Dependence, 80(1), 105–116.

    PubMed  Google Scholar 

  • Stinson, F. S., Ruan, W. J., Pickering, R., & Grant, B. F. (2006). Cannabis use disorders in the USA: Prevalence, correlates and co-morbidity. Psychological Medicine, 36(10), 1447–1460.

    PubMed  Google Scholar 

  • Swan, G. E., & Carmelli, D. (1997a). Behavior genetic investigations of cigarette smoking and related issues in twins. In K. Blum & E. P. Noble (Eds.), Handbook of psychiatric genetics (pp. 387–406). Boca Raton, FL: CRC Press Inc.

    Google Scholar 

  • Swan, G. E., Carmelli, D., & Cardon, L. R. (1996). The consumption of tobacco, alcohol, and coffee in Caucasian male twins: A multivariate genetic analysis. Journal of Substance Abuse, 8(1), 19–31.

    PubMed  Google Scholar 

  • Swan, G. E., Carmelli, D., & Cardon, L. R. (1997b). Heavy consumption of cigarettes, alcohol and coffee in male twins. Journal of Studies in Alcohol, 58(2), 182–190.

    Google Scholar 

  • Tercyak, K. P., Britto, M. T., Hanna, K. M., Hollen, P. J., & Hudson, M. M. (2008). Prevention of tobacco use among medically at-risk children and adolescents: Clinical and research opportunities in the interest of public health. Journal of Pediatric Psychology, 33(2), 119–132.

    PubMed  Google Scholar 

  • Tercyak, K. P., Peshkin, B. N., Wine, L. A., & Walker, L. R. (2006). Interest of adolescents in genetic testing for nicotine addiction susceptibility. Preventive Medicine, 42(1), 60–65.

    PubMed  Google Scholar 

  • Thompson, L. L., Whitmore, E. A., Raymond, K. M., & Crowley, T. J. (2006). Measuring impulsivity in adolescents with serious substance and conduct problems. Assessment, 13(1), 3–15.

    PubMed  Google Scholar 

  • Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452(7187), 638–642.

    PubMed  Google Scholar 

  • True, W. R., Heath, A. C., Scherrer, J. F., Xian, H., Lin, N., Eisen, S. A., et al. (1999). Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. American Journal of Medical Genetics, 88(4), 391–397.

    PubMed  Google Scholar 

  • True, W. R., Xian, H., Scherrer, J. F., Madden, P. A., Bucholz, K. K., Heath, A. C., et al. (1999). Common genetic vulnerability for nicotine and alcohol dependence in men. Archives in General Psychiatry, 56(7), 655–661.

    Google Scholar 

  • Uhl, G. R., Liu, Q. R., Drgon, T., Johnson, C., Walther, D., & Rose, J. E. (2007). Molecular genetics of nicotine dependence and abstinence: Whole genome association using 520,000 SNPs. BMC Genetics, 8, 10.

    PubMed  Google Scholar 

  • Voineskos, S., De Luca, V., Mensah, A., Vincent, J. B., Potapova, N., & Kennedy, J. L. (2007). Association of alpha4beta2 nicotinic receptor and heavy smoking in schizophrenia. Journal of Psychiatry and Neuroscience, 32(6), 412–416.

    PubMed  Google Scholar 

  • Welton, N. J., Johnstone, E. C., David, S. P., & Munafo, M. R. (2008). A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation. Nicotine and Tobacco Research, 10(1), 231–240.

    PubMed  Google Scholar 

  • Whiting, P. J. (2003). GABA-A receptor subtypes in the brain: A paradigm for CNS drug discovery? Drug Discovery Today, 8(10), 445–450.

    PubMed  Google Scholar 

  • Williams, S. H. (2005). Medications for treating alcohol dependence. American Family Physician, 72(9), 1775–1780.

    PubMed  Google Scholar 

  • World Health Organization. (2008). Management of substance abuse. Retrieved from http://www.who.int/substance_abuse/facts/alcohol/en/index.html

  • Xu, X., Scott, M. M., & Deneris, E. S. (2006). Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes. Molecular and Cellular Biology, 26(15), 5636–5649.

    PubMed  Google Scholar 

  • Yoshida, A. (1994). Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases. Alcohol and Alcoholism, 29(6), 693–696.

    PubMed  Google Scholar 

  • Young, S. E., Rhee, S. H., Stallings, M. C., Corley, R. P., & Hewitt, J. K. (2006). Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: General or specific? Behavioral Genetics, 36(4), 603–615.

    Google Scholar 

  • Zakhari, S. (2006). Overview: How is alcohol metabolized by the body? Alcohol Research and Health, 29(4), 245–254.

    PubMed  Google Scholar 

  • Zeiger, J., Haberstick, B. C., Schlaepfer, I., Collins, A. C., Corley, R. P., Crowley, T. J., et al. (2007). The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Human Molecular Genetics, 17(5), 724–734.

    PubMed  Google Scholar 

  • Zondervan, K. T., & Cardon, L. R. (2004). The complex interplay among factors that influence allelic association. Nature Reviews Genetics, 5(2), 89–100.

    PubMed  Google Scholar 

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Hoft, N.R., Sakai, J.T., Ehringer, M.A. (2010). Tobacco and Alcohol Use Behaviors. In: Tercyak, K. (eds) Handbook of Genomics and the Family. Issues in Clinical Child Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5800-6_15

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