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A Role for Complement in Glaucoma?

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Book cover Inflammation and Retinal Disease: Complement Biology and Pathology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 703))

Abstract

Chronic open angle glaucoma is a degenerative optic neuropathy that can lead to blindness. We have shown that one of the major genes with altered expression in the glaucomatous retina is complement component C1q in both animal models of the disease as well as in humans. These observations together with evidence of upregulation of other complement components within the retina suggest a role for complement in the pathogenesis of this disease. We review the current evidence that supports such a role and discuss possible mechanisms through which complement may act. A thorough understanding of these mechanisms is important in allowing us to rationally design new therapeutic approaches.

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Authors and Affiliations

  1. Departments of Cell Biology and Ophthalmology, SUNY Downstate Medical center NY, 450 Clarkson Ave, 5, Brooklyn, NY, 11203, USA

    John Danias

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  1. Lizhen Ren
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  2. John Danias
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Correspondence to John Danias .

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Editors and Affiliations

  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, USA

    John D. Lambris

  2. , Department of Ophthalmology and Visual S, University of Illinois at Chicago, Chicago, 62269-3745, USA

    Anthony P. Adamis

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Ren, L., Danias, J. (2010). A Role for Complement in Glaucoma?. In: Lambris, J., Adamis, A. (eds) Inflammation and Retinal Disease: Complement Biology and Pathology. Advances in Experimental Medicine and Biology, vol 703. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5635-4_7

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