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Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients pp 343–354Cite as

Sexuality and Pregnancy Before and After Kidney Transplantation

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Abstract

One of the many successes provided by solid organ transplantation is restoration of sexual and reproductive function. These are two areas often given limited discussion, yet they are important elements of a normal life. This chapter will review published literature on sexuality and reproduction and provide guidelines for the counseling and management of patients before and after pregnancy.

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References

  1. Anantharaman P, Schmidt. RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis. 2007;14:119–125.

    Article  PubMed  Google Scholar 

  2. Palmer BF. Sexual dysfunction in uremia. J Am Soc Nephrol. 1999;10:1381–1388.

    CAS  PubMed  Google Scholar 

  3. Raiz L, Davies EA, Ferguson. RM. Sexual functioning following renal transplantation. Health Soc Work. 2003;28:264–272.

    PubMed  Google Scholar 

  4. Schover LR, Novick AC, Steinmuller DR, Goormastic. M. Sexuality, fertility, and renal transplantation: a survey of survivors. J Sex Marital Ther. 1990;16:3–13.

    CAS  PubMed  Google Scholar 

  5. Saha MT, Saha HH, Niskanen LK, Salmela KT, Pasternack. AI. Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron. 2002;92:735–737.

    Article  CAS  PubMed  Google Scholar 

  6. Lim VS, Henriquez C, Sievertsen G, Frohman. LA. Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. Ann Intern Med. 1980;93:21–27.

    CAS  PubMed  Google Scholar 

  7. Holley JL, Schmidt RJ, Bender FH, Dumler F, Schiff. M. Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis. 1997;29:685–690.

    Article  CAS  PubMed  Google Scholar 

  8. Zeyneloglu HB, Oktem M, Durak. T. Male infertility after renal transplantation: achievement of pregnancy after intracytoplasmic sperm injection. Transplant Proc. 2005;37:3081–3084.

    Article  CAS  PubMed  Google Scholar 

  9. Akbari F, Alavi M, Esteghamati A, Mehrsai A, Djaladat H, Zohrevand R, Pourmand. G. Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int. 2003;92:281–283.

    Article  CAS  PubMed  Google Scholar 

  10. Tondolo V, Citterio F, Panocchia N, Nanni G, Castagneto. M. Sirolimus impairs improvement of the gonadal function after renal transplantation. Am J Transplant 2005;5:197.

    Article  PubMed  Google Scholar 

  11. Tondolo V, Citterio F, Panocchia N, Nanni G, Favi E, Brescia A, Castagneto. M. Gonadal function and immunosuppressive therapy after renal transplantation. Transplant Proc. 2005;37:1915–1917.

    Article  CAS  PubMed  Google Scholar 

  12. Fritsche L, Budde K, Dragun D, Einecke G, Diekmann F, Neumayer. HH. Testosterone concentrations and sirolimus in male renal transplant patients. Am J Transplant. 2004;4:130–131.

    Article  CAS  PubMed  Google Scholar 

  13. Kaczmarek I, Groetzner J, Adamidis I, Landwehr P, Mueller M, Vogeser M, Gerstorfer M, Uberfuhr P, Meiser B, Reichart. B. Sirolimus impairs gonadal function in heart transplant recipients. Am J Transplant. 2004;4:1084–1088.

    Article  CAS  PubMed  Google Scholar 

  14. Guazzelli CA, Torloni MR, Sanches TF, Barbieri M, Pestana. JO. Contraceptive counseling and use among 197 female kidney transplant recipients. Transplantation. 2008;86:669–672.

    Article  PubMed  Google Scholar 

  15. Fischer MJ, Lehnerz SD, Hebert JR, Parikh. CR. Kidney disease is an independent risk factor for adverse fetal and maternal outcomes in pregnancy. Am J Kidney Dis. 2004;43:415–423.

    Article  PubMed  Google Scholar 

  16. McKay D, Josephson. M. Reproduction and Transplantation: report on the AST consensus conference on reproductive issues and transplantation. Am J Transplantation. 2005;5:1–8.

    Article  Google Scholar 

  17. Josephson MA, McKay. DB. Considerations in the medical management of pregnancy in transplant recipients. Adv Chronic Kidney Dis. 2007;14:156–167.

    Article  PubMed  Google Scholar 

  18. Estes CM, Westhoff. C. Contraception for the transplant patient. Semin Perinatol. 2007;31:372–377.

    Article  PubMed  Google Scholar 

  19. Davison JM, Bailey. DJ. Pregnancy following renal transplantation. J Obstet Gynaecol Res. 2003;29:227–233.

    Article  PubMed  Google Scholar 

  20. Reddy SS, Holley. JL. Management of the pregnant chronic dialysis patient. Adv Chronic Kidney Dis. 2007;14:146–155.

    Article  PubMed  Google Scholar 

  21. McKay DB, Josephson. MA. Pregnancy in recipients of solid organs – effects on mother and child. N Engl J Med. 2006;354:1281–1293.

    Article  CAS  PubMed  Google Scholar 

  22. 22. Coscia LA, Constantinescu S, Moritz MJ, Radomski JS, Gaughan WJ, McGrory CH, Armenti. VT. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl 2007;29–42.

    Google Scholar 

  23. Sibanda N, Briggs JD, Davison JM, Johnson RJ, Rudge. CJ. Pregnancy after organ transplantation: a report from the UK Transplant pregnancy registry. Transplantation. 2007;83:1301–1307.

    Article  PubMed  Google Scholar 

  24. McKay DB, Josephson. MA. Pregnancy after kidney transplantation. Clin J Am Soc Nephrol 2008;3(Suppl 2):S117-S125.

    Article  PubMed  Google Scholar 

  25. del Mar Colon M, Hibbard. JU. Obstetric considerations in the management of pregnancy in kidney transplant recipients. Adv Chronic Kidney Dis. 2007;14:168–177.

    Article  PubMed  Google Scholar 

  26. Podymow T, August. P. Hypertension in pregnancy. Adv Chronic Kidney Dis. 2007;14:178–190.

    Article  PubMed  Google Scholar 

  27. Umans JG. Medications during pregnancy: antihypertensives and immunosuppressives. Adv Chronic Kidney Dis. 2007;14:191–198.

    Article  PubMed  Google Scholar 

  28. Baumwell S, Karumanchi. SA. Pre-eclampsia: clinical manifestations and molecular mechanisms. Nephron Clin Pract. 2007;106:c72-c81.

    Article  PubMed  Google Scholar 

  29. Stratta P, Canavese C, Giacchino F, Mesiano P, Quaglia M, Rossetti. M. Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities. J Nephrol. 2003;16:792–806.

    PubMed  Google Scholar 

  30. Morales J, Hernandez Poblete G, Andres A, Prieto C, Hernandez E, Rodicio. J. Uric acid handling, pregnancy and cyclosporin in renal transplant women. Nephron. 1990;56:97–98.

    Article  CAS  PubMed  Google Scholar 

  31. 31. Mutter WP, Karumanchi. SA. Molecular mechanisms of preeclampsia. Microvasc Res 2008 Jan;75(1):1–8.

    Google Scholar 

  32. EBPG Expert group in renal transplantation. European best practice guidelines for renal transplantation. Section IV. Long-term management of the transplant recipient. IV.10. Pregnancy in renal transplant recipients. Nephrol Dial Transplant 2002;17(Suppl 4):50–55.

    Article  Google Scholar 

  33. Davison JM. Changes in renal function in early pregnancy in women with one kidney. Yale J Biol Med. 1978;51:347–349.

    CAS  PubMed  Google Scholar 

  34. Katz AI, Davison JM, Hayslett JP, Singson E, Lindheimer. MD. Pregnancy in women with kidney disease. Kidney Int. 1980;18:192–206.

    Article  CAS  PubMed  Google Scholar 

  35. Fischer MJ. Chronic kidney disease and pregnancy: maternal and fetal outcomes. Adv Chronic Kidney Dis. 2007;14:132–145.

    Article  PubMed  Google Scholar 

  36. Ghanem ME, El-Baghdadi LA, Badawy AM, Bakr MA, Sobhe MA, Ghoneim MA. Pregnancy outcome after renal allograft transplantation: 15 years experience. Reprod Biol. 2005;121:178–181.

    CAS  Google Scholar 

  37. Oliveira LG, Sass N, Sato JL, Ozaki KS, Medina Pestana. JO. Pregnancy after renal transplantation – a five-yr single-center experience. Clin Transplant. 2007;21:301–304.

    Article  PubMed  Google Scholar 

  38. Ross DS, Dollard SC, Victor M, Sumartojo E, Cannon. MJ. The epidemiology and prevention of congenital cytomegalovirus infection and disease: activities of the Centers for Disease Control and Prevention Workgroup. J Womens Health (Larchmt). 2006;15:224–229.

    Article  Google Scholar 

  39. Ornoy A, Diav-Citrin. O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol. 2006;21:399–409.

    Article  CAS  PubMed  Google Scholar 

  40. Michaels MG. Treatment of congenital cytomegalovirus: where are we now?. Expert Rev Anti Infect Ther. 2007;5:441–448.

    Article  PubMed  Google Scholar 

  41. Gardella C, Brown. ZA. Managing varicella zoster infection in pregnancy. Cleve Clin J Med. 2007;74:290–296.

    Article  PubMed  Google Scholar 

  42. Shiono Y, Mun HS, He N, Nakazaki Y, Fang H, Furuya M, Aosai F, Yano. A. Maternal-fetal transmission of Toxoplasma gondii in interferon-gamma deficient pregnant mice. Parasitol Int. 2007;56:141–148.

    Article  CAS  PubMed  Google Scholar 

  43. Sifontis NM, Coscia LA, Constantinescu S, Lavelanet AF, Moritz MJ, Armenti. VT. Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus. Transplantation. 2006;82:1698–1702.

    Article  CAS  PubMed  Google Scholar 

  44. LeRay C, Coulomb A, Elefant E, Frydman R, Audibert. F. Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations. Obstet Gynecol. 2004;103:1091–1094.

    Google Scholar 

  45. Stanley CW, Gottlieb R, Zager R, Eisenberg J, Richmond R, Moritz MJ, Armenti. VT. Developmental well-being in offspring of women receiving cyclosporine post-renal transplant. Transplant Proc. 1999;31:241–242.

    Article  CAS  PubMed  Google Scholar 

  46. Phillips DI. Programming of the stress response: a fundamental mechanism underlying the long-term effects of the fetal environment?. J Intern Med. 2007;261:453–460.

    Article  CAS  PubMed  Google Scholar 

  47. 47. Neubauer AP, Voss W, Kattner. E. Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment. Eur J Pediatr 2008 Jan;167(1):87–95.

    Google Scholar 

  48. Phillips DI. External influences on the fetus and their long-term consequences. Lupus. 2006;15:794–800.

    Article  CAS  PubMed  Google Scholar 

  49. Saenger P, Czernichow P, Hughes I, Reiter. EO. Small for gestational age: short stature and beyond. Endocr Rev. 2007;28:219–251.

    Article  CAS  PubMed  Google Scholar 

  50. Schreuder M, Delemarre-van de Waal H, van Wijk A. Consequences of intrauterine growth restriction for the kidney. Kidney Blood Press Res. 2006;29:108–125.

    Article  CAS  PubMed  Google Scholar 

  51. 51. Reyes L, Manalich. R. Long-term consequences of low birth weight. Kidney Int 2005;97(Suppl):s68–s77

    Google Scholar 

  52. Taylor HG, Minich N, Bangert B, Filipek PA, Hack. M. Long-term neuropsychological outcomes of very low birth weight: associations with early risks for periventricular brain insults. J Int Neuropsychol Soc. 2004;10:987–1004.

    PubMed  Google Scholar 

  53. Gluckman PD, Hanson. MA. The consequences of being born small - an adaptive perspective. Horm Res 2006;65(Suppl 3):5–14.

    Article  CAS  PubMed  Google Scholar 

  54. American Academy of Pediatrics. Committee on Drugs the transfer of drugs and other chemicals into human milk. Pediatrics1994;93:137–150.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Kidney and Pancreas Transplantation, Beth Israel Deaconess Medical Center, Transplant, Boston, MA, USA

    Martha Pavlakis MD

  2. Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA, USA

    Dianne B. McKay MD

  3. Sharp Memorial Hospital, San Diego, CA, USA

    Dianne B. McKay MD

Authors
  1. Martha Pavlakis MD
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  2. Dianne B. McKay MD
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Corresponding author

Correspondence to Martha Pavlakis MD .

Editor information

Editors and Affiliations

  1. Scripps Research Institute, N.Torrey Pines Rd. 10550, La Jolla, 92037, USA

    Dianne B. McKay

  2. Division of Transplantation, Sharp Memorial Hospital, Frost Street 7910, San Diego, 92123, USA

    Steven M. Steinberg

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Pavlakis, M., McKay, D.B. (2010). Sexuality and Pregnancy Before and After Kidney Transplantation. In: McKay, D., Steinberg, S. (eds) Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1690-7_20

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  • DOI: https://doi.org/10.1007/978-1-4419-1690-7_20

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-1689-1

  • Online ISBN: 978-1-4419-1690-7

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