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Neurocognitive Function in Systemic Autoimmune and Rheumatic Diseases

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Abstract

An autoimmune disease is a disorder in which the body’s immune system attacks itself. The dysregulation of the immune system associated with systemic autoimmune diseases can affect various organs systems, including the brain. This chapter will review the neuropsychological involvement and the resulting cognitive changes associated with three systemic autoimmune or rheumatic diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren’s syndrome (SS). Diagnosis, neuropsychological assessment, and treatment planning are challenging since most of the disease manifestations are nonspecific. Due to the abundant literature on cognitive dysfunction in SLE as compared to the other two diseases, the discussion of cognition is focused mainly in SLE.

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    Amy H. Kao & Suzanne L. Gharib

  2. University of Pittsburgh School of Medicine, Pittsburgh, PA, 15232, USA

    Carol M. Greco

  3. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

    Sue R. Beers

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  1. Amy H. Kao
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  2. Carol M. Greco
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  3. Suzanne L. Gharib
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  4. Sue R. Beers
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Correspondence to Amy H. Kao .

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Editors and Affiliations

  1. Division of Oncology, Children's Hospital of Philadelphia, Market Street 3535, Philadelphia, 19104, USA

    Carol L. Armstrong

  2. Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, 15213, USA

    Lisa Morrow

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Kao, A.H., Greco, C.M., Gharib, S.L., Beers, S.R. (2010). Neurocognitive Function in Systemic Autoimmune and Rheumatic Diseases. In: Armstrong, C., Morrow, L. (eds) Handbook of Medical Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1364-7_19

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