Abstract
Neuroimaging and behavioral studies have proven to be critical in establishing normative developmental trajectories for brain and behavior relationships. These studies suggest that delayed maturation of neural systems during adolescence may lead to increased risk taking and result in negative consequences, such as substance abuse and addiction. Specifically, discontinuities in the development of prefrontal cortical functioning may foster a neural and behavioral landscape that can increase novelty seeking, lead to increased impulsive actions and choices, and set the stage for substance abuse. This chapter focuses on functional neuroimaging studies of adolescents, examines conceptual challenges related to understanding risky behavior and substance abuse within a neurobiological framework, and considers future directions, such as using neuroimaging to determine biomarkers for risk and resilience through development.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Adleman, N. E., Menon, V., Blasey, C. M., White, C. D., Warsofsky, I. S., Glover, G. H., et al. (2002). A developmental fMRI study of the Stroop color-word task. Neuroimage, 16(1), 61–75.
Ainslie, G. (2001). Breakdown of will. Cambridge ; New York: Cambridge University Press.
Anderson, K. G., Schweinsburg, A., Paulus, M. P., Brown, S. A., & Tapert, S. (2005). Examining personality and alcohol expectancies using functional magnetic resonance imaging (fMRI) with adolescents. J Stud Alcohol, 66(3), 323–331.
Ballard, K., & Knutson, B. (2009). Dissociable neural representations of future reward magnitude and delay during temporal discounting. Neuroimage, 45(1), 143–150.
Balleine, B. W., & Dickinson, A. (1998). Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology, 37(4–5), 407–419.
Banks, S. J., Eddy, K. T., Angstadt, M., Nathan, P. J., & Phan, K. L. (2007). Amygdala-frontal connectivity during emotion regulation. Soc Cogn Affect Neurosci, 2(4), 303–312.
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996). Psychobiology of novelty seeking and drug seeking behavior. Behav Brain Res, 77(1–2), 23–43.
Bari, A., Dalley, J. W., & Robbins, T. W. (2008). The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nat Protoc, 3(5), 759–767.
Barratt, E. S. (1994). Impulsiveness and Agression. In J. Monahan and H. J. Steadman (Eds.), Violence and Mental Disorder: Developments in Risk Assessment (pp. 61–79). Chicago: University of Chicago Press.
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci, 19(13), 5473–5481.
Behrendt, S., Wittchen, H. U., Hofler, M., Lieb, R., & Beesdo, K. (2009). Transitions from first substance use to substance use disorders in adolescence: is early onset associated with a rapid escalation? Drug Alcohol Depend, 99(1–3), 68–78.
Bjork, J. M., Hommer, D. W., Grant, S. J., & Danube, C. (2004a). Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol, 34(2–3), 133–150.
Bjork, J. M., Knutson, B., Fong, G. W., Caggiano, D. M., Bennett, S. M., & Hommer, D. W. (2004b). Incentive-elicited brain activation in adolescents: similarities and differences from young adults. J Neurosci, 24(8), 1793–1802.
Bjork, J. M., Smith, A. R., Danube, C. L., & Hommer, D. W. (2007). Developmental differences in posterior mesofrontal cortex recruitment by risky rewards. J Neurosci, 27(18), 4839–4849.
Bolla, K. I., Eldreth, D. A., Matochik, J. A., & Cadet, J. L. (2005). Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage, 26(2), 480–492.
Bornovalova, M. A., Cashman-Rolls, A., O’Donnell, J. M., Ettinger, K., Richards, J. B., deWit, H., et al. (2009). Risk taking differences on a behavioral task as a function of potential reward/loss magnitude and individual differences in impulsivity and sensation seeking. Pharmacol Biochem Behav, 93(3), 258–262.
Braet, W., Johnson, K. A., Tobin, C. T., Acheson, R., Bellgrove, M. A., Robertson, I. H., et al. (2009). Functional developmental changes underlying response inhibition and error-detection processes. Neuropsychologia.
Brand, M., Grabenhorst, F., Starcke, K., Vandekerckhove, M. M., & Markowitsch, H. J. (2007). Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease. Neuropsychologia, 45(6), 1305–1317.
Brand, M., Labudda, K., & Markowitsch, H. J. (2006). Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Netw, 19(8), 1266–1276.
Cain, M. E., Saucier, D. A., & Bardo, M. T. (2005). Novelty seeking and drug use: contribution of an animal model. Exp Clin Psychopharmacol, 13(4), 367–375.
Camerer, C., & Weber, M. (1992). Recent developments in modeling preferences: Uncertainty and ambiguity. Journal of Risk and Uncertainty, 5 325–370.
Cardinal, R. N. (2006). Neural systems implicated in delayed and probabilistic reinforcement. Neural Netw, 19(8), 1277–1301.
Chambers, C. D., Garavan, H., & Bellgrove, M. A. (2009). Insights into the neural basis of response inhibition from cognitive and clinical neuroscience. Neurosci Biobehav Rev, 33(5), 631–646.
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003). Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. Am J Psychiatry, 160(6), 1041–1052.
Chevrier, A. D., Noseworthy, M. D., & Schachar, R. (2007). Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI. Hum Brain Mapp, 28(12), 1347–1358.
Chudasama, Y., Passetti, F., Rhodes, S. E., Lopian, D., Desai, A., & Robbins, T. W. (2003). Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res, 146(1–2), 105–119.
Cloninger, C. R. (1994). The temperament and character inventory (TCI) : a guide to its development and use (1st ed.). St. Louis, Mo.: Center for Psychobiology of Personality, Washington University.
Cohen, J. D., McClure, S. M., & Yu, A. J. (2007). Should I stay or should I go? How the human brain manages the trade-off between exploitation and exploration. Philos Trans R Soc Lond B Biol Sci, 362(1481), 933–942.
Crews, F., He, J., & Hodge, C. (2007). Adolescent cortical development: a critical period of vulnerability for addiction. Pharmacol Biochem Behav, 86(2), 189–199.
Cunningham, M. G., Bhattacharyya, S., & Benes, F. M. (2002). Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence. J Comp Neurol, 453(2), 116–130.
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004). Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev, 28(7), 771–784.
Daw, N. D., O’Doherty, J. P., Dayan, P., Seymour, B., & Dolan, R. J. (2006). Cortical substrates for exploratory decisions in humans. Nature, 441(7095), 876–879.
Dawe, S., Gullo, M. J., & Loxton, N. J. (2004). Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. Addict Behav, 29(7), 1389–1405.
de Wit, H. (2009). Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol, 14(1), 22–31.
de Wit, H., & Richards, J. B. (2004). Dual determinants of drug use in humans: reward and impulsivity. Nebr Symp Motiv, 50, 19–55.
de Wit, S., & Dickinson, A. (2009). Associative theories of goal-directed behaviour: a case for animal-human translational models. Psychol Res, 73(4), 463–476.
Diergaarde, L., Pattij, T., Poortvliet, I., Hogenboom, F., de Vries, W., Schoffelmeer, A. N., et al. (2008). Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats. Biol Psychiatry, 63(3), 301–308.
Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2010). Motivational systems in adolescence: Possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn, 72(1), 114–123.
Eigsti, I. M., Zayas, V., Mischel, W., Shoda, Y., Ayduk, O., Dadlani, M. B., et al. (2006). Predicting cognitive control from preschool to late adolescence and young adulthood. Psychol Sci, 17(6), 478–484.
Eippert, F., Veit, R., Weiskopf, N., Erb, M., Birbaumer, N., & Anders, S. (2007). Regulation of emotional responses elicited by threat-related stimuli. Hum Brain Mapp, 28(5), 409–423.
Ernst, M., & Fudge, J. L. (2009). A developmental neurobiological model of motivated behavior: anatomy, connectivity and ontogeny of the triadic nodes. Neurosci Biobehav Rev, 33(3), 367–382.
Ernst, M., Nelson, E. E., Jazbec, S., McClure, E. B., Monk, C. S., Leibenluft, E., et al. (2005). Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. Neuroimage, 25(4), 1279–1291.
Ernst, M., Pine, D. S., & Hardin, M. (2006). Triadic model of the neurobiology of motivated behavior in adolescence. Psychol Med, 36(3), 299–312.
Ernst, M., Romeo, R. D., & Andersen, S. L. (2008). Neurobiology of the development of motivated behaviors in adolescence: A window into a neural systems model. Pharmacol Biochem Behav.
Eshel, N., Nelson, E. E., Blair, R. J., Pine, D. S., & Ernst, M. (2007). Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate cortices. Neuropsychologia, 45(6), 1270–1279.
Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology (Berl), 146(4), 348–361.
Fareri, D. S., Martin, L. N., & Delgado, M. R. (2008). Reward-related processing in the human brain: developmental considerations. Dev Psychopathol, 20(4), 1191–1211.
Fillmore, M. T., & Rush, C. R. (2002). Impaired inhibitory control of behavior in chronic cocaine users. Drug Alcohol Depend, 66(3), 265–273.
Galvan, A., Hare, T., Voss, H., Glover, G., & Casey, B. J. (2007). Risk-taking and the adolescent brain: who is at risk? Dev Sci, 10(2), F8–F14.
Galvan, A., Hare, T. A., Parra, C. E., Penn, J., Voss, H., Glover, G., et al. (2006). Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. J Neurosci, 26(25), 6885–6892.
Geier, C., & Luna, B. (2009). The maturation of incentive processing and cognitive control. Pharmacol Biochem Behav, 93(3), 212–221.
Goldberg, J. H., Millstein, S., Schwartz, A., & Halpern-Felsher, B. (2009). Intertemporal tradeoffs: perceiving the risk in the benefits of marijuana in a prospective study of adolescents and young adults. Med Decis Making, 29(2), 182–192.
Gruber, S. A., & Yurgelun-Todd, D. A. (2005). Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Res Cogn Brain Res, 23(1), 107–118.
Gullo, M. J., & Dawe, S. (2008). Impulsivity and adolescent substance use: rashly dismissed as “all-bad”? Neurosci Biobehav Rev, 32(8), 1507–1518.
Hare, T. A., Tottenham, N., Galvan, A., Voss, H. U., Glover, G. H., & Casey, B. J. (2008). Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. Biol Psychiatry, 63(10), 927–934.
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006). Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J Neurosci, 26(51), 13213–13217.
Herwig, U., Abler, B., Walter, H., & Erk, S. (2007). Expecting unpleasant stimuli – an fMRI study. Psychiatry Res, 154(1), 1–12.
Hester, R., Nestor, L., & Garavan, H. (2009). Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users. Neuropsychopharmacology, 34(11), 2450–2458.
Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., & Camerer, C. F. (2005). Neural systems responding to degrees of uncertainty in human decision-making. Science, 310(5754), 1680–1683.
Huettel, S. A., Stowe, C. J., Gordon, E. M., Warner, B. T., & Platt, M. L. (2006). Neural signatures of economic preferences for risk and ambiguity. Neuron, 49(5), 765–775.
Ivanov, I., Schulz, K. P., London, E. D., & Newcorn, J. H. (2008). Inhibitory control deficits in childhood and risk for substance use disorders: a review. Am J Drug Alcohol Abuse, 34(3), 239–258.
Jentsch, J. D., & Taylor, J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology (Berl), 146(4), 373–390.
Joseph, J. E., Liu, X., Jiang, Y., Lynam, D., & Kelly, T. H. (2009). Neural correlates of emotional reactivity in sensation seeking. Psychol Sci, 20(2), 215–223.
Kable, J. W., & Glimcher, P. W. (2007). The neural correlates of subjective value during intertemporal choice. Nat Neurosci, 10(12), 1625–1633.
Kaufman, J. N., Ross, T. J., Stein, E. A., & Garavan, H. (2003). Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imaging. J Neurosci, 23(21), 7839–7843.
Killgore, W. D., Oki, M., & Yurgelun-Todd, D. A. (2001). Sex-specific developmental changes in amygdala responses to affective faces. Neuroreport, 12(2), 427–433.
Knutson, B., & Greer, S. M. (2008). Anticipatory affect: neural correlates and consequences for choice. Philos Trans R Soc Lond B Biol Sci, 363(1511), 3771–3786.
Kollins, S. H. (2003). Delay discounting is associated with substance use in college students. Addict Behav, 28(6), 1167–1173.
Krain, A. L., Hefton, S., Pine, D. S., Ernst, M., Castellanos, F. X., Klein, R. G., et al. (2006). An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making. J Child Psychol Psychiatry, 47(10), 1023–1030.
Lawrence, A. J., Luty, J., Bogdan, N. A., Sahakian, B. J., & Clark, L. (2009). Impulsivity and response inhibition in alcohol dependence and problem gambling. Psychopharmacology (Berl).
Lenroot, R. K., & Giedd, J. N. (2006). Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev, 30(6), 718–729.
Li, C. S., Luo, X., Yan, P., Bergquist, K., & Sinha, R. (2009). Altered impulse control in alcohol dependence: neural measures of stop signal performance. Alcohol Clin Exp Res, 33(4), 740–750.
Lopez, B., Schwartz, S. J., Prado, G., Campo, A. E., & Pantin, H. (2008). Adolescent neurological development and its implications for adolescent substance use prevention. J Prim Prev, 29(1), 5–35.
Luna, B., Padmanabhan, A., & O’Hearn, K. (2009). What has fMRI told us about the Development of Cognitive Control through Adolescence? Brain Cogn.
Luna, B., & Sweeney, J. A. (2004). The emergence of collaborative brain function: FMRI studies of the development of response inhibition. Ann N Y Acad Sci, 1021, 296–309.
Luna, B., Thulborn, K. R., Munoz, D. P., Merriam, E. P., Garver, K. E., Minshew, N. J., et al. (2001). Maturation of widely distributed brain function subserves cognitive development. Neuroimage, 13(5), 786–793.
Marsh, R., Zhu, H., Schultz, R. T., Quackenbush, G., Royal, J., Skudlarski, P., et al. (2006). A developmental fMRI study of self-regulatory control. Hum Brain Mapp, 27(11), 848–863.
May, J. C., Delgado, M. R., Dahl, R. E., Stenger, V. A., Ryan, N. D., Fiez, J. A., et al. (2004). Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biol Psychiatry, 55(4), 359–366.
Mayberg, H. S. (2003). Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull, 65, 193–207.
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004). Separate neural systems value immediate and delayed monetary rewards. Science, 306(5695), 503–507.
McNamee, R. L., Dunfee, K. L., Luna, B., Clark, D. B., Eddy, W. F., & Tarter, R. E. (2008). Brain activation, response inhibition, and increased risk for substance use disorder. Alcohol Clin Exp Res, 32(3), 405–413.
Mischel, W., Shoda, Y., & Rodriguez, M. I. (1989). Delay of gratification in children. Science, 244(4907), 933–938.
Mitchell, S. H. (1999). Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl), 146(4), 455–464.
Mobini, S., Body, S., Ho, M. Y., Bradshaw, C. M., Szabadi, E., Deakin, J. F., et al. (2002). Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology (Berl), 160(3), 290–298.
Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001). Psychiatric aspects of impulsivity. Am J Psychiatry, 158(11), 1783–1793.
Monterosso, J., & Ainslie, G. (1999). Beyond discounting: possible experimental models of impulse control. Psychopharmacology (Berl), 146(4), 339–347.
Monterosso, J. R., Ainslie, G., Xu, J., Cordova, X., Domier, C. P., & London, E. D. (2007). Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task. Hum Brain Mapp, 28(5), 383–393.
Monterosso, J. R., Aron, A. R., Cordova, X., Xu, J., & London, E. D. (2005). Deficits in response inhibition associated with chronic methamphetamine abuse. Drug Alcohol Depend, 79(2), 273–277.
Nitschke, J. B., Sarinopoulos, I., Mackiewicz, K. L., Schaefer, H. S., & Davidson, R. J. (2006). Functional neuroanatomy of aversion and its anticipation. Neuroimage, 29(1), 106–116.
Olson, E. A., Collins, P. F., Hooper, C. J., Muetzel, R., Lim, K. O., & Luciana, M. (2009). White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study. J Cogn Neurosci, 21(7), 1406–1421.
Olson, E. A., Hooper, C. J., Collins, P., & Luciana, M. (2007). Adolescents’ performance on delay and probability discounting tasks: contributions of age, intelligence, executive functioning, and self-reported externalizing behavior. Pers Individ Dif, 43(7), 1886–1897.
Paulus, M. P. (2007). Decision-making dysfunctions in psychiatry – altered homeostatic processing? Science, 318(5850), 602–606.
Perry, J. L., & Carroll, M. E. (2008). The role of impulsive behavior in drug abuse. Psychopharmacology (Berl), 200(1), 1–26.
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E. (2005). Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study. Biol Psychiatry, 57(3), 210–219.
Platt, M. L., & Huettel, S. A. (2008). Risky business: the neuroeconomics of decision making under uncertainty. Nat Neurosci, 11(4), 398–403.
Poulos, C. X., Le, A. D., & Parker, J. L. (1995). Impulsivity predicts individual susceptibility to high levels of alcohol self-administration. Behav Pharmacol, 6(8), 810–814.
Reynolds, B., de Wit, H., & Richards, J. (2002). Delay of gratification and delay discounting in rats. Behav Processes, 59(3), 157.
Reynolds, B., Penfold, R. B., & Patak, M. (2008). Dimensions of impulsive behavior in adolescents: laboratory behavioral assessments. Exp Clin Psychopharmacol, 16(2), 124–131.
Robinson, E. S., Eagle, D. M., Economidou, D., Theobald, D. E., Mar, A. C., Murphy, E. R., et al. (2009). Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in ‘waiting’ versus ‘stopping’. Behav Brain Res, 196(2), 310–316.
Rubia, K., Smith, A. B., Taylor, E., & Brammer, M. (2007). Linear age-correlated functional development of right inferior fronto-striato-cerebellar networks during response inhibition and anterior cingulate during error-related processes. Hum Brain Mapp, 28(11), 1163–1177.
Rubia, K., Smith, A. B., Woolley, J., Nosarti, C., Heyman, I., Taylor, E., et al. (2006). Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive control. Hum Brain Mapp, 27(12), 973–993.
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. (2006). Separate neural pathways process different decision costs. Nat Neurosci, 9(9), 1161–1168.
Rushworth, M. F., & Behrens, T. E. (2008). Choice, uncertainty and value in prefrontal and cingulate cortex. Nat Neurosci, 11(4), 389–397.
Schepis, T. S., Adinoff, B., & Rao, U. (2008). Neurobiological processes in adolescent addictive disorders. Am J Addict, 17(1), 6–23.
Schoenbaum, G., Setlow, B., Saddoris, M. P., & Gallagher, M. (2003). Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala. Neuron, 39(5), 855–867.
Schultz, W., Preuschoff, K., Camerer, C., Hsu, M., Fiorillo, C. D., Tobler, P. N., et al. (2008). Explicit neural signals reflecting reward uncertainty. Philos Trans R Soc Lond B Biol Sci, 363(1511), 3801–3811.
Segal, B., Huba, G. J., & Singer, J. L. (1980). Drugs, daydreaming, and personality : a study of college youth. Hillsdale, N.J.: L. Erlbaum Associates.
Shukla, R. K., & Kelley, M. S. (2007). Investigating how decisions to use marijuana change over time. Subst Use Misuse, 42(9), 1401–1425.
Silveri, M. M., Rohan, M. L., Pimentel, P. J., Gruber, S. A., Rosso, I. M., & Yurgelun-Todd, D. A. (2006). Sex differences in the relationship between white matter microstructure and impulsivity in adolescents. Magn Reson Imaging, 24(7), 833–841.
Silveri, M. M., Tzilos, G. K., Pimentel, P. J., & Yurgelun-Todd, D. A. (2004). Trajectories of adolescent emotional and cognitive development: effects of sex and risk for drug use. Ann N Y Acad Sci, 1021, 363–370.
Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev, 24(4), 417–463.
Steinberg, L. (2004). Risk taking in adolescence: what changes, and why? Ann N Y Acad Sci, 1021, 51–58.
Steinberg, L. (2008). A Social Neuroscience Perspective on Adolescent Risk-Taking. Dev Rev, 28(1), 78–106.
Steinberg, L., Graham, S., O’Brien, L., Woolard, J., Cauffman, E., & Banich, M. (2009). Age differences in future orientation and delay discounting. Child Dev, 80(1), 28–44.
Stevens, M. C., Kiehl, K. A., Pearlson, G. D., & Calhoun, V. D. (2007). Functional neural networks underlying response inhibition in adolescents and adults. Behav Brain Res, 181(1), 12–22.
Streeter, C. C., Terhune, D. B., Whitfield, T. H., Gruber, S., Sarid-Segal, O., Silveri, M. M., et al. (2008). Performance on the Stroop predicts treatment compliance in cocaine-dependent individuals. Neuropsychopharmacology, 33(4), 827–836.
Tamm, L., Menon, V., & Reiss, A. L. (2002). Maturation of brain function associated with response inhibition. J Am Acad Child Adolesc Psychiatry, 41(10), 1231–1238.
Tapert, S. F., Schweinsburg, A. D., Drummond, S. P., Paulus, M. P., Brown, S. A., Yang, T. T., et al. (2007). Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berl), 194(2), 173–183.
Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., et al. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Am J Psychiatry, 160(6), 1078–1085.
Tversky, A., & Kahneman, D. (1981). The framing of decisions and the psychology of choice. Science, 211(4481), 453–458.
Van Leijenhorst, L., Zanolie, K., Van Meel, C. S., Westenberg, P. M., Rombouts, S. A., & Crone, E. A. (2009). What Motivates the Adolescent? Brain Regions Mediating Reward Sensitivity across Adolescence. Cereb Cortex.
Verbruggen, F., & Logan, G. D. (2008). Response inhibition in the stop-signal paradigm. Trends Cogn Sci, 12(11), 418–424.
Verdejo-Garcia, A. J., Perales, J. C., & Perez-Garcia, M. (2007). Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict Behav, 32(5), 950–966.
Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008). Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron, 59(6), 1037–1050.
Weber, B. J., & Huettel, S. A. (2008). The neural substrates of probabilistic and intertemporal decision making. Brain Res, 1234, 104–115.
Winstanley, C. A., Dalley, J. W., Theobald, D. E., & Robbins, T. W. (2004). Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology, 29(7), 1331–1343.
Wittmann, B. C., Daw, N. D., Seymour, B., & Dolan, R. J. (2008). Striatal activity underlies novelty-based choice in humans. Neuron, 58(6), 967–973.
Xu, L., Liang, Z. Y., Wang, K., Li, S., & Jiang, T. (2009). Neural mechanism of intertemporal choice: from discounting future gains to future losses. Brain Res, 1261, 65–74.
Yang, T. T., Simmons, A. N., Matthews, S. C., Tapert, S. F., Frank, G. K., Bischoff-Grethe, A., et al. (2009). Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport, 20(1), 19–23.
Yates, J. F., & Watts, R. A. (1975). Preferences for deferred losses. Organizational Behavior and Human Performance, 13, 294–306.
Yurgelun-Todd, D. (2007). Emotional and cognitive changes during adolescence. Curr Opin Neurobiol, 17(2), 251–257.
Yurgelun-Todd, D., & Killgore, W. D. (2006). Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI study. Neurosci Lett, 406(3), 194–199.
Zuckerman, M. (1994). Behavioral expressions and biosocial bases of sensation seeking. Cambridge ; New York: Cambridge University Press.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Churchwell, J.C., Yurgelun-Todd, D.A. (2011). Neuroimaging, Adolescence, and Risky Behavior. In: Bardo, M., Fishbein, D., Milich, R. (eds) Inhibitory Control and Drug Abuse Prevention. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1268-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1268-8_6
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1267-1
Online ISBN: 978-1-4419-1268-8
eBook Packages: MedicineMedicine (R0)