Abstract
In contrast to the detailed descriptions of intracellular mechanisms for circadian rhythm generation across disparate species, our understanding of the rules for connecting and synchronizing the circadian oscillators is comparatively sleight. Here, we review the recent advances from model organisms which have highlighted the key cells and pathways that participate in circadian timekeeping. We limit this review to discussions of neuronal circadian clocks, their inputs and outputs. We organize the chapter as we see the archetypal circadian system is structured: neurons form rhythm-generating nodes which are connected in order that they synchronize to one another and produce coherent output timing signals. These networked circadian oscillators entrain to environmental timing cues through input pathways and coordinately drive rhythmic behaviors through output pathways. We highlight evidence for rhythmic modulation of the input pathways (gates or Zeitnehmers) and the other mechanisms which affect the coordination of the circadian network. We conclude by featuring those areas we believe offer good opportunities to advance the main lines of inquiry.
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Herzog, E.D., Taghert, P.H. (2010). Circadian Neural Networks. In: Albrecht, U. (eds) The Circadian Clock. Protein Reviews, vol 12. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1262-6_8
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