Abstract
Being a mosaic of its bacterial and eukaryal relatives, archaeal RNase P presents an attractive model for biochemical and structural comparative studies. The archaeal RNase P RNA subunit is more conserved with the bacterial counterpart, but its protein subunits share homology only with those associated with the eukaryal RNase P. This review summarizes recent advances in understanding protein-aided RNA catalysis in archaeal RNase P, and highlights findings that exemplify the diversity of RNase P and the dynamic co-evolution of this catalytic ribonucleoprotein complex.
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Acknowledgments
The authors are grateful to Mark P. Foster (OSU) for assistance with preparation of Fig. 9.2 and for valuable discussions. The author, Venkat Gopalan, acknowledges support from the NSF (MCB-0238233 and MCB-0843543) and the NIH (GM067947 to MPF and VG).
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Lai, L.B., Cho, IM., Chen, WY., Gopalan, V. (2010). Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives. In: Liu, F., Altman, S. (eds) Ribonuclease P. Protein Reviews, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1142-1_9
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