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Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications

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Nanodiamonds

Abstract

The onset and recurrence of cancer is one of the major biomedical quandaries of our time. Currently, surgically removed tumors often leave behind a residual cancer cell population. As not all cancer cells can be detected to ensure complete tumor removal, systemic and widespread chemotherapy is usually injected into the ­bloodstream to attempt to target the remaining cancer cells. This can result in ­devastating side effects because the cancer drugs flow freely throughout the bloodstream with a reduced ability to target-specific regions. This treatment kills both healthy and unhealthy cells, and thus the quality of life of cancer patients is significantly reduced.

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Acknowledgment

Financial Support from the US National Science Foundation and the World Class University program (R33-10079) under the Ministry of Education, Science and Technology, Republic of Korea, are greatly appreciated.

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Authors and Affiliations

  1. Northwestern University, Evanston, IL, USA

    Wing Kam Liu, Ashfaq Adnan, Adrian M. Kopacz, Michelle Hallikainen, Dean Ho, Robert Lam, Jessica Lee, Ted Belytschko & George Schatz

  2. National Cheng Kung University (NCKU), Tainan, Taiwan

    Yonhua Tzeng

  3. Sungkyunkwan University (SKKU), Seoul, South Korea

    Young-Jin Kim, Seunghyun Baik, Moon Ki Kim & Taesung Kim

  4. Seoul National University (SNU), Seoul, South Korea

    Junghoon Lee & Eung-Soo Hwang

  5. Korea Advanced Institute of Science and Technology (KAIST), Daedeok Science Town, Daejeon, South Korea

    Seyoung Im

  6. Nanocarbon Research Institute (NCRI), Shinshu University, Nagano Prefecture, Japan

    Eiji Ōsawa

  7. Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, VIC, Australia

    Amanda Barnard

  8. Institute for Advanced and Molecular Studies (IAMS), Academia Sinica, Taipei, Taiwan

    Huan-Cheng Chang

  9. National Chiao Tung University (NCTU), Hsinchu, Taiwan

    Chia-Ching Chang

  10. International Center for Numerical Methods in Engineering (CIMNE), Barcelona, Spain

    Eugenio Oñate

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  1. Dept. Biomedical Engineering , Northwestern University, Sheridan Road 2145, Evanston, 60208-3107, U.S.A.

    Dean Ho

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Liu, W.K. et al. (2010). Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications. In: Ho, D. (eds) Nanodiamonds. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0531-4_12

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