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Bridging Mucosal Innate Immunity to the Adaptive Immune System

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Immunity Against Mucosal Pathogens

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Abstract

The human adult mucosa covers immense surface area 200 times greater than that of the skin, i.e., 400 m2. The mucosal immune system mediates the symbiotic relationship between hosts and endogenous microorganisms (commensal bacteria) and serves as a physical and immunological defense against invading pathogens and/or toxins. To accomplish this task, the mucosal immune system, consisting of an integrated network of tissues, lymphoid and non-lymphoid cells, and effector molecules such as antibodies, chemokines, and cytokines for host protection, tightly controls the balance between immune responsiveness (i.e., immunity and inflammation) and non-responsiveness (i.e., tolerance). The mucosal immune system, antigen-presenting cells, lymphocytes, and the factors they produce are essential for orchestrating specific mucosal immune responses. Cells of the mucosa initiate and support the development of both innate and adaptive immunity. Here, we discuss how the innate mucosal immune responses lead to host adaptive immunity.

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  1. Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    Rajesh Singh

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  1. Rajesh Singh
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  2. James W. Lillard
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  1. Davis School of Medicine Department of Medical Microbiology and Immunology, University of California, Davis CA 95616, USA

    Michael Vajdy

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Singh, R., Lillard, J.W. (2008). Bridging Mucosal Innate Immunity to the Adaptive Immune System. In: Vajdy, M. (eds) Immunity Against Mucosal Pathogens. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8412-6_4

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