Skip to main content
SpringerLink
Log in

Prediction of Metastasis and Recurrence of Breast Carcinoma: Detection of Survivin-Expressing Circulating Cancer Cells

  • Chapter
Methods of Cancer Diagnosis, Therapy and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 1))

  • 2095 Accesses

Breast cancer is the most common type of cancer for women in the world. According to Bray et al. (2004), it is responsible for over one million of the estimated ten million neoplasms diagnosed worldwide each year. Globally, it is also the leading cause of cancer deaths among women, responsible for 375,000 deaths in the year 2000 as documented by Ferlay et al. (2001). Major causes for these breast cancer-related deaths, as indicated by Zieglschmid et al. (2005) have been metastases and recurrences. As a result, the ability to predict an individual patient’s risk of metastasis and recurrence after surgical resection of the primary tumor is of great importance. This ability would also allow for the planning of optimized adjuvant therapies as well as monitoring the efficacy of treatments.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 309.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 399.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adida, C., Crotty, P.L., McGrath, J., Berrebi, D., Diebold, J., and Altieri, D.C. 1998. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am. J. Pathol. 152: 43–49

    PubMed  CAS  Google Scholar 

  • Aerts, J., Wynendaele, W., Paridaens, R., Christiaens M.R., van den Bogaert, W., van Oosterom, A.T., and Vandekerckhove, F. 2001. A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood. Ann. Oncol. 12: 39–46

    Article  PubMed  CAS  Google Scholar 

  • Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison S.J., and Clarke, M.F. 2003. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA. 100: 3983–3988

    Article  PubMed  CAS  Google Scholar 

  • Ambrosini, G., Adida, C., and Altieri, D.C. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3: 917–921

    Article  PubMed  CAS  Google Scholar 

  • Bosma, A.J., Weigelt, B., Lambrechts, A.C., Verhagen, O.J., Pruntel, R., Hart, A.A., Rodenhuis, S., and van't Veer, L.J. 2002. Detection of circulating breast tumor cells by differential expression of marker genes. Clin. Cancer Res. 8: 1871–1877

    PubMed  CAS  Google Scholar 

  • Bray, F., McCarron, P., and Parkin, M.D. 2004. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res. 6: 229–239

    Article  PubMed  Google Scholar 

  • Chiou, S.K., Jones, M.K., and Tarnawski, A.S. 2003. Survivin—an anti-apoptosis protein: its biological roles and implications for cancer and beyond. Med. Sci. Monit. 9: 125–129

    Google Scholar 

  • Cianfrocca, M., and Goldstein, L.J. 2004. Prognostic and predictive factors in early stage breast cancer. Oncologist 9: 606–616

    Article  PubMed  Google Scholar 

  • Denley, H., Pinder, S.E., Elston, C.W., Lee, A.H.S., and Ellis, I.O. 2002. Preoperative assessment of prognostic factors in breast cancer. J. Clin. Pathol. 54: 20–24

    Article  Google Scholar 

  • Ferlay, J., Bray, F., Pisani, P., and Parkin, D.M. 2001. GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, IARC Cancer Base No. 5. Lyon: IARC Press

    Google Scholar 

  • Fisher, B., Jeong, J.H., Anderson, S., Bryant, J., Fisher, E.R., and Wolmark, N. 2002. Twenty-five year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. New Engl. J. Med. 347: 567–575

    Article  PubMed  Google Scholar 

  • Gilbey, A.M., Burnett, D., Coleman, R.E., and Holen, I. 2004. The detection of circulating breast cancer cells. J. Clin. Pathol. 57: 903–911

    Article  PubMed  CAS  Google Scholar 

  • Goeminne, J.C., Guillaume, T., Salmon, M., Machiels, J.P., D'Hondt, V., and Symann, M. 1999. Unreliability of carcinoembryonic antigen (CEA) reverse transcriptase-polymerase chain reaction (RT-PCR) in detecting contaminating breast cancer cells in peripheral blood stem cells due to induction of CEA by growth factors. Bone Marrow Transplant 24: 769–775

    Article  PubMed  CAS  Google Scholar 

  • Gross, H.J., Verwer, B., Houck, D., Hoffman, R.A., and Recktenwald, D. 1995. Model study detecting breast cancer cells in peripheral blood mononuclear cells at frequencies as low as 10−7. Proc. Natl. Acad. Sci. USA. 92: 537–541

    Article  PubMed  CAS  Google Scholar 

  • Konno, R., Yamakawa, H., Utsunomiya, H., Ito, K., Sato, S., and Yajima, A. 2000. Expression of survivin and Bcl-2 in the normal human endometrium. Mol. Hum. Reprod. 6: 529–534

    Article  PubMed  CAS  Google Scholar 

  • Johnson, M.E., and Howerth, E.W. 2004. Survivin: a bifunctional inhibitor of apoptosis protein. Vet. Pathol. 41: 599–607

    Article  PubMed  CAS  Google Scholar 

  • Jung, R., Kruger, W., Hosch, S., Holweg, M., Kroger, N., Gutensohn, K., Wagener, C., Neumaier, M., and Zander, A.R. 1998. Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro. Br. J. Cancer 78: 1194–1198

    PubMed  CAS  Google Scholar 

  • Lacroix, M. 2006. Significance, detection and markers of disseminated breast cancer cells. Endoc.-Relat. Cancer 13: 1033–1067

    Article  CAS  Google Scholar 

  • Lambrechts, A.C., Bosma, A.J., Klaver, S.G., Top, B., Perebolte, L., van't Veer, L.J., and Rodenhuis, S. 1999. Comparison of immuno-cytochemistry, reverse transcriptase polymerase chain reaction, and nucleic acid sequence-based amplification for the detection of circulating breast cancer cells. Breast Cancer Res. Treat. 56: 219–231

    Article  PubMed  CAS  Google Scholar 

  • Li, F., and Brattain, M.G. 2006. Role of the survivin gene in pathophysiology. Am. J. Pathol. 169: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Manhani, A.R., Manhani, R., Soares, H.P., Bendit, I., Lopes, F., Nicoletti, A.G. Fonseca, F.L., Novaes, M., Zatta, S.M., Arias, V. , Giralt, S., and del Giglio, A. 2001. CK-19 expression by RT-PCR in the peripheral blood of breast cancer patients correlates with response to chemotherapy. Breast Cancer Res. Treat. 66: 249–254

    Article  PubMed  CAS  Google Scholar 

  • Mehes, G., Witt, A., Kubista, E., and Ambros, P.F. 2001. Circulating breast cancer cells are frequently apoptotic. Am. J. Pathol. 159: 17–20

    PubMed  CAS  Google Scholar 

  • Mirza, A.N., Mirza, N.O., Vlastos, G., and Singletary, S.E. 2002. Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years. Ann. Surg. 235: 10–26

    Article  PubMed  Google Scholar 

  • Muller, V., and Pantel, K. 2004. Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives. Breast Cancer Res. 6: 258–261

    Article  PubMed  Google Scholar 

  • Nasu, S., Yagihashi, A., Izawa, A., Saito, K., Asanuma, K., Nakamura, M., Kobayashi, D., Okazaki, M., and Watanabe, N. 2002. Survivin mRNA expression in patients with breast cancer. Anticancer Res. 22: 1839–1843

    PubMed  CAS  Google Scholar 

  • Pachmann, K., Heiss, P., Demel, U., and Tilz, G. 2001. Detection and quantification of small numbers of circulating tumor cells in peripheral blood using laser scanning cytometer (LSC). Clin. Chem. Lab. Med. 39: 811–817

    Article  PubMed  CAS  Google Scholar 

  • Pantel, K., and Brakenhoff, R.H. 2004. Dissecting the metastatic cascade. Nat. Rev. Cancer 4: 448–456

    Article  PubMed  CAS  Google Scholar 

  • Pizzoferrato, E., Liu, Y., Gambotto, A., Armstrong, M.J., Stang, M.T., Gooding, W.E., Alber, S.M., Shand, S.H., Watkins, S.C., Storkus, W.J., and Yim, J.H. 2004. Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. Cancer Res. 64: 8381–8388

    Article  PubMed  CAS  Google Scholar 

  • Ring, A., Smith, I.E., and Dowsett, M. 2004. Circulating tumor cells in breast cancer. Lancet Oncol. 5: 79–88

    Article  PubMed  Google Scholar 

  • Ryan, B., O'Donovan, N., Browne, B., O'Shea, C., Crown, J., Hill, A.D., McDermott, E., O'Higgins, N ., and Duffy, M.J. 2005. Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer. Br. J. Cancer 92: 120–124

    Article  PubMed  CAS  Google Scholar 

  • Smith, B.M., Slade, M.J., English, J., Graham, H., Luchtenborg, M., Sinnett, H.D., Cross, N.C., and Coombes, R.C. 2000. Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemi-cal techniques. J. Clin. Oncol. 18: 1432–1439

    PubMed  CAS  Google Scholar 

  • Span, P.N., Sweep, F.C., Wiegerinck, E.T., Tjan-Heijnen, V.C., Manders, P., Beex, L.V., and de Kok, J.B. 2004. Survivin is an independent prognostic marker for risk stratification of breast cancer patients. Clin. Chem. 50: 1986–1993

    Article  PubMed  CAS  Google Scholar 

  • Span, P.N., Tjan-Heijnen, V.C., Heuvel, J.J., de Kok, J.B., Foekens, J.A., and Sweep, F.C. 2006. Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer? Clin. Chem. 52: 1693–1700

    Article  PubMed  CAS  Google Scholar 

  • Stathopoulou, A., Vlachonikolis, I., Mavroudis, D., Perraki, M., Kouroussis, C., Apostolaki, S., Malamos, N., Kakolyris, S., Kotsakis, A., Xenidis, N., Reppa, D., and Georgoulias, V. 2002. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: valuation of their prognostic significance. J. Clin. Oncol. 20: 3404–3412

    Article  PubMed  CAS  Google Scholar 

  • Taback, B., Chan, A.D., Kuo, C.T., Bostick, P.J., Wang, H.J., Giuliano, A.E., and Hoon, D.S. 2001. Detection of occult metastatic breast cancer cells in blood by a multimolecular marker assay: correlation with clinical stage of disease. Cancer Res. 61: 8845–8850

    PubMed  CAS  Google Scholar 

  • Valasek, M.A., and Repa, J.J. 2005. The power of realtime PCR. Advan. Physiol. Educ. 29: 151–159

    Article  Google Scholar 

  • Yie, S.M., Luo, B., Ye, N.Y., Xie, K., and Ye, S.R. 2006. Detection of Survivin expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA. Clin. Exp. Metastasis 23: 279–289

    Article  PubMed  CAS  Google Scholar 

  • Zach, O., Kasparu, H., Wagner, H., Krieger, O., and Lutz, D. 2002. Prognostic value of tumour cell detection in peripheral blood of breast cancer patients. Acta. Med. Austriaca 29 [Suppl 59]: 32–34

    Google Scholar 

  • Zaffaroni, N. and Daidone, M.G. 2002. Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions. Drug Resist. Updates 5: 65–72

    Article  CAS  Google Scholar 

  • Zaffaroni, N., Pennati, M., and Daidone, M.G. 2005. Survivin as a target for new anticancer interventions. J. Cell. Mol. Med. 9: 360–372

    Article  PubMed  CAS  Google Scholar 

  • Zieglschmid, V., Hollmann, C., and Bocher, O. 2005. Detection of disseminated tumor cells in peripheral blood. Crit. Rev. Clin. Lab. Sci. 42: 155–196

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Core Laboratory, Sichuan Provincial Hospital, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, 32 Yi Huan Lu Xi Er Duan 610072, Chengdu, Sichuan, Peoples Republic of China, 610072

    Shang-mian Yie

Authors
  1. Shang-mian Yie
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, NJ, USA

    M. A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V.

About this chapter

Cite this chapter

Yie, Sm. (2008). Prediction of Metastasis and Recurrence of Breast Carcinoma: Detection of Survivin-Expressing Circulating Cancer Cells. In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-8369-3_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8368-6

  • Online ISBN: 978-1-4020-8369-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation