It is known that hypoxia causes proliferation of pulmonary arterial smooth muscle cells (PASMC) and that hypoxia can also affect the endogenous vasodilators such as nitric oxide (NO) and Prostacyclin I2 (PGI2). Recently, it has been noted that the suppressive effect of NO on the proliferation of PASMC was partially exerted via the activation of p21, a cyclin-dependent kinase (CDK) inhibitor. We therefore decided to clarify the role of CDK inhibitors, p21, p27 and tumour suppressor p53 in PASMC in the presence/absence of exogenous NO/PGI2 during hypoxia.
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Ishizaki, T. et al. (2007). Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53. In: Aldashev, A., Naeije, R. (eds) Problems of High Altitude Medicine and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6300-8_6
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DOI: https://doi.org/10.1007/978-1-4020-6300-8_6
Publisher Name: Springer, Dordrecht
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