Abstract
Gastric cancer is one of the leading worldwide causes of cancer death with about 866,000 deaths each year. The incidence varies tremendously throughout the world, with the highest incidence occurring in South Korea at 66.5–72.5 per 100,000 males and 19.5–30.4 per 100,000 females [1]. In contrast, incidence in the United States is about one-tenth that of South Korea, and the estimated number of new gastric cancer cases in the United States in 2008 was 21,500, and the estimated number of deaths was 10,880 [2]. Overall the rates of gastric adenocarcinoma have declined over the past 50 years, but there has been a significant increase in the subset of tumors of the proximal stomach and gastroesophageal junction [3].
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Pandalai, P.K., Yoon, S.S. (2010). Hereditary Diffuse Gastric Cancer. In: Chung, D., Haber, D. (eds) Principles of Clinical Cancer Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-93846-2_8
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