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Structure and Evolution of Tropomyosin Genes

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Tropomyosin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 644))

Abstract

Tropomyosins constitute a family of highly related actin-binding proteins found in the animal kingdom from yeast to human. In vertebrates, they are encoded by a multigene family where each member can produce several isoforms through alternative splicing and for some of them with alternate promoters. Tropomyosin isoform diversity has considerably increased during evolution from invertebrates to vertebrates and stems from the duplication of ancestral genes. The advance of genomic sequence information on various animals has expanded our knowledge on the structure of tropomyosin genes in different phyla and subphyla. We present the organisation of tropomyosin genes in different major phyla and the phylogenetic comparison of their structure highlights the evolution of this multigene family.

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Author information

Authors and Affiliations

  1. Oncology Research Unit, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia

    Bernadette Vrhovski

  2. Université Victor Segalen Bordeaux, Bordeaux, France

    Nadine Thézé

  3. UMR 5164-CNRS, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076, Bordeaux Cedex, France

    Pierre Thiébaud

Authors
  1. Bernadette Vrhovski
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  2. Nadine Thézé
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  3. Pierre Thiébaud
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Correspondence to Pierre Thiébaud .

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Editors and Affiliations

  1. Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Peter Gunning PhD

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Vrhovski, B., Thézé, N., Thiébaud, P. (2008). Structure and Evolution of Tropomyosin Genes. In: Gunning, P. (eds) Tropomyosin. Advances in Experimental Medicine and Biology, vol 644. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85766-4_2

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