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References
Alessi,D. R.,Sakamoto,K., andBayascas,J. R.2006. LKB1-dependent signaling pathways. Annu Rev Biochem,75:137–163.
Altenberg,B. andGreulich,K. O.2004. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics,84:1014–1020.
Baggetto,L. G.1992. Role of mitochondria in carcinogenesis. Eur J Cancer,29A:156–159.
Bensaad,K.,Tsuruta,A.,Selak,M. A.,Vidal,M. N.,Nakano,K.,Bartrons,R.,Gottlieb,E., andVousden,K. H.2006. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell,126:107–120.
Bi,X.,Lin,Q.,Foo,T. W.,Joshi,S.,You,T.,Shen,H. M.,Ong,C. N.,Cheah,P. Y.,Eu,K. W., andHew,C. L.2006. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Mol Cell Proteomics,5:1119–1130.
Birnbaum,M. J.,Haspel,H. C., andRosen,O. M.1987. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science,235:1495–1498.
Boveri,T.1902. Über mehrpolige Mitosen als Mittel zur Analyse des Zellkerns., Vol. 35, Vehr. d. phys. med. Ges. zu Wurzburg. Wurzburg: 67–90.
Boveri,T.1914. Zur Frage der Entstehung maligner Tumoren. Gustav Fischer Verlag.Jena:
Brown,J.1962. Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. Metabolism,11:1098–1112.
Bulavin,D. V. andFornace,A. J.,Jr. 2004. p38 MAP kinase’s emerging role as a tumor suppressor. Adv Cancer Res,92:95–118.
Bustamante,E. andPedersen,P. L.1977. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA,74:3735–3739.
Bustamante,E.,Morris,H. P., andPedersen,P. L.1981. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem,256:8699–8704.
Carew,J. S. andHuang,P.2002. Mitochondrial defects in cancer. Mol Cancer,1:9.
Chen, Z., Lu, W., Garcia-Prieto, C., and Huang, P. 2007. The Warburg effect and its cancer therapeutic implications. J Bioenerg Biomembr
Cuezva,J. M.,Krajewska,M.,de Heredia,M. L.,Krajewski,S.,Santamaria,G.,Kim,H.,Zapata,J. M.,Marusawa,H.,Chamorro,M., andReed,J. C.2002. The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res,62:6674–6681.
Cuezva,J. M.,Chen,G.,Alonso,A. M.,Isidoro,A.,Misek,D. E.,Hanash,S. M., andBeer,D. G.2004. The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis. Carcinogenesis,25:1157–1163.
Dang,C. V.,Lewis,B. C.,Dolde,C.,Dang,G., andShim,H.1997. Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr,29:345–354.
De Lena,M.,Lorusso,V.,Latorre,A.,Fanizza,G.,Gargano,G.,Caporusso,L.,Guida,M.,Catino,A.,Crucitta,E.,Sambiasi,D., andMazzei,A.2001. Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. Eur J Cancer,37:364–368.
Di Cosimo,S.,Ferretti,G.,Papaldo,P.,Carlini,P.,Fabi,A., andCognetti,F.2003. Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. Drugs Today (Barc),39:157–174.
Ebert,B. L.,Firth,J. D., andRatcliffe,P. J.1995. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem,270:29083–29089.
Elstrom,R. L.,Bauer,D. E.,Buzzai,M.,Karnauskas,R.,Harris,M. H.,Plas,D. R.,Zhuang,H.,Cinalli,R. M.,Alavi,A.,Rudin,C. M., andThompson,C. B.2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res,64:3892–3899.
Fantin,V. R.,St-Pierre,J., andLeder,P.2006. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell,9:425–434.
Fearon,E. R. andVogelstein,B.1990. A genetic model for colorectal tumorigenesis. Cell,61:759–767.
Firth,J. D.,Ebert,B. L., andRatcliffe,P. J.1995. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem,270:21021–21027.
Flier,J. S.,Mueckler,M. M.,Usher,P., andLodish,H. F.1987. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science,235:1492–1495.
Floridi,A.,Paggi,M. G.,Marcante,M. L.,Silvestrini,B.,Caputo,A., andDe Martino,C.1981. Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. J Natl Cancer Inst,66:497–499.
Floridi,A.,Bruno,T.,Miccadei,S.,Fanciulli,M.,Federico,A., andPaggi,M. G.1998. Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism. Biochem Pharmacol,56:841–849.
Gambhir,S. S.2002. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer,2:683–693.
Gatenby,R. A. andGillies,R. J.2004. Why do cancers have high aerobic glycolysis? Nat Rev Cancer,4:891–899.
Gerber,J.,Mühlenhoff,U., andLill,R.2003. An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1. EMBO Rep,4:906–911.
Geschwind,J. F.,Ko,Y. H.,Torbenson,M. S.,Magee,C., andPedersen,P. L.2002. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res,62:3909–3913.
Grover-McKay,M.,Walsh,S. A.,Seftor,E. A.,Thomas,P. A., andHendrix,M. J.1998. Role for glucose transporter 1 protein in human breast cancer. Pathol Oncol Res,4:115–120.
Hawkins,R. A. andPhelps,M. E.1988. PET in clinical oncology. Cancer Metastasis Rev,7:119–142.
Herrmann, P. C. and Herrmann, E. C. 2007. Oxygen metabolism and a potential role for cytochrome c oxidase in the Warburg effect. J Bioenerg Biomembr
Hervouet,E.,Demont,J.,Pecina,P.,Vojtiskova,A.,Houstek,J.,Simonnet,H., andGodinot,C.2005. A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis,26:531–539.
Ingram,D. K.,Zhu,M.,Mamczarz,J.,Zou,S.,Lane,M. A.,Roth,G. S., anddeCabo,R.2006. Calorie restriction mimetics: an emerging research field. Aging Cell,5:97–108.
Inoki,K.,Zhu,T., andGuan,K. L.2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell,115:577–590.
Isidoro,A.,Martinez,M.,Fernandez,P. L.,Ortega,A. D.,Santamaria,G.,Chamorro,M.,Reed,J. C., andCuezva,J. M.2004. Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem J,378:17–20.
Isidoro,A.,Casado,E.,Redondo,A.,Acebo,P.,Espinosa,E.,Alonso,A. M.,Cejas,P.,Hardisson,D.,Fresno Vara,J. A.,Belda-Iniesta,C.,Gonzalez-Baron,M., andCuezva,J. M.2005. Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis. Carcinogenesis,26:2095–2104.
Jelluma,N.,Yang,X.,Stokoe,D.,Evan,G. I.,Dansen,T. B., andHaas-Kogan,D. A.2006. Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res,4:319–330.
Jones,R. G.,Plas,D. R.,Kubek,S.,Buzzai,M.,Mu,J.,Xu,Y.,Birnbaum,M. J., andThompson,C. B.2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell,18:283–293.
Kahn,B. B.,Alquier,T.,Carling,D., andHardie,D. G.2005. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab,1:15–25.
Kim,J. W.,Tchernyshyov,I.,Semenza,G. L., andDang,C. V.2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab,3:177–185.
Ko,Y. H.,Pedersen,P. L., andGeschwind,J. F.2001. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett,173:83–91.
Ko,Y. H.,Smith,B. L.,Wang,Y.,Pomper,M. G.,Rini,D. A.,Torbenson,M. S.,Hullihen,J., andPedersen,P. L.2004. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun,324:269–275.
Koukourakis,M. I.,Giatromanolaki,A.,Sivridis,E.,Gatter,K. C., andHarris,A. L.2005. Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia,7:1–6.
Lane,M. A.1998. 2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction. JOURNAL OF ANTI-AGING MEDICINE,1:327–336.
Lu,H.,Forbes,R. A., andVerma,A.2002. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem,277:23111–23115.
Lu,H.,Dalgard,C. L.,Mohyeldin,A.,McFate,T.,Tait,A. S., andVerma,A.2005. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem,280:41928–41939.
Ma, W., Sung, H. J., Park, J. Y., Matoba, S., and Hwang, P. M. 2007. A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr
Macdonald,F. andFord,C. H. J.1992. Oncogenes and tumor Suppressor genes (Medical perspectives series), BIOS Scientfic Publishers.Oxford: 112.
Manchester,K.1997. The quest by three giants of science for an understanding of cancer. Endeavour,21:72–76.
Maschek,G.,Savaraj,N.,Priebe,W.,Braunschweiger,P.,Hamilton,K.,Tidmarsh,G. F.,De Young,L. R., andLampidis,T. J.2004. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res,64:31–34.
Mathupala,S. P.,Heese,C., andPedersen,P. L.1997. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem,272:22776–22780.
Matoba,S.,Kang,J. G.,Patino,W. D.,Wragg,A.,Boehm,M.,Gavrilova,O.,Hurley,P. J.,Bunz,F., andHwang,P. M.2006. p53 regulates mitochondrial respiration. Science,312:1650–1653.
Maxwell,P. H.,Dachs,G. U.,Gleadle,J. M.,Nicholls,L. G.,Harris,A. L.,Stratford,I. J.,Hankinson,O.,Pugh,C. W., andRatcliffe,P. J.1997. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA,94:8104–8109.
McKusick, V. A., Kniffin, C. L., Tiller, G. E., Wright, M. J., Hamosh, A., Antonarakis, S. E., Rasmussen, S. A., Smith, M., Brennan, P., and Rasooly, R. S. 2007. Online mendelian inheritance in man: von Hippel-Lindau syndrome (OMIM 193300).http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193300,
Mühlenhoff,U.,Richhardt,N.,Ristow,M.,Kispal,G., andLill,R.2002. The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet,11:2025–2036.
Natali,P. G.,Salsano,F.,Viora,M.,Nista,A.,Malorni,W.,Marolla,A., andDe Martino,C.1984. Inhibition of aerobic glycolysis in normal and neoplastic lymphoid cells induced by Lonidamine [1-(2,4-dichlorobenzyl)-I-H-indazol-3-carboxylic acid]. Oncology,41 (Suppl.1): 7–14.
Osthus,R. C.,Shim,H.,Kim,S.,Li,Q.,Reddy,R.,Mukherjee,M.,Xu,Y.,Wonsey,D.,Lee,L. A., andDang,C. V.2000. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem,275:21797–21800.
Oudard,S.,Carpentier,A.,Banu,E.,Fauchon,F.,Celerier,D.,Poupon,M. F.,Dutrillaux,B.,Andrieu,J. M., andDelattre,J. Y.2003. Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. J Neurooncol,63:81–86.
Papandreou,I.,Cairns,R. A.,Fontana,L.,Lim,A. L., andDenko,N. C.2006. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab,3:187–197.
Pasteur, L. 1861. Influence de l’oxygene sur le developpement de la levure et la fermentation alcoolique. Bulletin de la Societe Chimique de Paris, p. 79–80.
Pedersen,P. L.1978. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res,22:190–274.
Pelicano,H.,Martin,D. S.,Xu,R. H., andHuang,P.2006a. Glycolysis inhibition for anticancer treatment. Oncogene,25:4633–4646.
Pelicano,H.,Xu,R. H.,Du,M.,Feng,L.,Sasaki,R.,Carew,J. S.,Hu,Y.,Ramdas,L.,Hu,L.,Keating,M. J.,Zhang,W.,Plunkett,W., andHuang,P.2006b. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol,175:913–923.
Petros,J. A.,Baumann,A. K.,Ruiz-Pesini,E.,Amin,M. B.,Sun,C. Q.,Hall,J.,Lim,S.,Issa,M. M.,Flanders,W. D.,Hosseini,S. H.,Marshall,F. F., andWallace,D. C.2005. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci USA,102:719–724.
Raghunand,N.,Gatenby,R. A., andGillies,R. J.2003. Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol,76 (S11–S22.Spec No. 1):
Ramanathan,A.,Wang,C., andSchreiber,S. L.2005. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA,102:5992–5997.
Rathmell,J. C.,Fox,C. J.,Plas,D. R.,Hammerman,P. S.,Cinalli,R. M., andThompson,C. B.2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol,23:7315–7328.
Reznick,R. M. andShulman,G. I.2006. The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol,574:33–39.
Robey,I. F.,Lien,A. D.,Welsh,S. J.,Baggett,B. K., andGillies,R. J.2005. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia,7:324–330.
Sakashita,M.,Aoyama,N.,Minami,R.,Maekawa,S.,Kuroda,K.,Shirasaka,D.,Ichihara,T.,Kuroda,Y.,Maeda,S., andKasuga,M.2001. Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological features. Eur J Cancer,37:204–209.
Schulz,T. J.,Thierbach,R.,Voigt,A.,Drewes,G.,Mietzner,B. H.,Steinberg,P.,Pfeiffer,A. F., andRistow,M.2006. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J Biol Chem,281:977–981.
Semenza,G. L.2001. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell,107:1–3.
Semenza, G. L. 2007. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J Bioenerg Biomembr
Semenza,G. L. andWang,G. L.1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol,12:5447–5454.
Semenza,G. L.,Roth,P. H.,Fang,H. M., andWang,G. L.1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem,269:23757–23763.
Shaw,R. J.2006. Glucose metabolism and cancer. Curr Opin Cell Biol,18:598–608.
Shim,H.,Dolde,C.,Lewis,B. C.,Wu,C. S.,Dang,G.,Jungmann,R. A.,Dalla-Favera,R., andDang,C. V.1997. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA,94:6658–6663.
Singh,D.,Banerji,A. K.,Dwarakanath,B. S.,Tripathi,R. P.,Gupta,J. P.,Mathew,T. L.,Ravindranath,T., andJain,V.2005. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol,181:507–514.
Singh,K. K.2004. Mitochondrial dysfunction is a common phenotype in aging and cancer. Ann NY Acad Sci,1019:260–264.
Smith,T. A.,Sharma,R. I.,Thompson,A. M., andPaulin,F. E.2006. Tumor 18F-FDG incorporation is enhanced by attenuation of P53 function in breast cancer cells in vitro. J Nucl Med,47:1525–1530.
Sols,A. andCrane,R. K.1954. Substrate specificity of brain hexokinase. J Biol Chem,210:581–595.
Stiles,B.,Groszer,M.,Wang,S.,Jiao,J., andWu,H.2004. PTENless means more. Dev Biol,273:175–184.
Stryer,L.1995. Biochemistry. W. H. Freeman.New York:
Taylor,R. W. andTurnbull,D. M.2005. Mitochondrial DNA mutations in human disease. Nat Rev Genet,6:389–402.
Thierbach,R.,Schulz,T. J.,Isken,F.,Voigt,A.,Mietzner,B.,Drewes,G.,von Kleist-Retzow,J. C.,Wiesner,R. J.,Magnuson,M. A.,Puccio,H.,Pfeiffer,A. F.,Steinberg,P., andRistow,M.2005. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span, and tumor growth in mice. Hum Mol Genet,14:3857–3864.
Timofeev,O.,Lee,T. Y., andBulavin,D. V.2005. A subtle change in p38 MAPK activity is sufficient to suppress in vivo tumorigenesis. Cell Cycle,4:118–120.
Vogelstein,B. andKinzler,K. W.1993. The multistep nature of cancer. Trends Genet,9:138–141.
Warburg, O. 1930. The Metabolism of Tumours. London: Constable.
Warburg, O. 1931. The oxygen-transferring ferment of respiration. Nobel Lecture,
Warburg,O.1956a. On the origin of cancer cells. Science,123:309–314.
Warburg,O.1956b. On respiratory impairment in cancer cells. Science,124:269–270.
Warburg,O.,Posener,K., andNegelein,E.1924. Über den Stoffwechsel der Tumoren (On metabolism of tumors). Biochemische Zeitschrift,152:319–344.
Warburg, O., Wind, F., and Negelein, E. 1926. The metabolism of tumors in the body. J Gen Physiol 519–530.
Weinhouse,S.1956. On respiratory impairment in cancer cells. Science,124:267–269.
Wu,M.,Neilson,A.,Swift,A. L.,Moran,R.,Tamagnine,J.,Parslow,D.,Armistead,S.,Lemire,K.,Orrell,J.,Teich,J.,Chomicz,S., andFerrick,D. A.2007. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol,292:C125–C136.
Xu,R. H.,Pelicano,H.,Zhou,Y.,Carew,J. S.,Feng,L.,Bhalla,K. N.,Keating,M. J., andHuang,P.2005. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res,65:613–621.
Younes,M.,Lechago,L. V., andLechago,J.1996. Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. Clin Cancer Res,2:1151–1154.
Zhang,X. D.,Deslandes,E.,Villedieu,M.,Poulain,L.,Duval,M.,Gauduchon,P.,Schwartz,L., andIcard,P.2006. Effect of 2-deoxy-d.-glucose on various malignant cell lines in vitro Anticancer Res,26:3561–3566.
Zhou,S.,Kachhap,S., andSingh,K. K.2003. Mitochondrial impairment in p53-deficient human cancer cells. Mutagenesis,18:287–292.
Zhu,Z.,Jiang,W.,McGinley,J. N., andThompson,H. J.2005. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res,65:7023–7030.
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Ristow, M., Schulz, T.J. (2009). Warburg and his Legacy. In: Mitochondria and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84835-8_2
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