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Coagulation in Cancer pp 95–114Cite as

Risk Factors for Thrombosis in Cancer Patients

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 148))

Venous thromboembolism (VTE), comprised of deep vein thrombosis (DVT) and its complication, pulmonary embolism (PE), is a multifactorial disease, involving complex interactions between environmental exposures and patients, including their hemostatic system and genetic predispositions. VTE is relatively common, with an overall average age- and sex-adjusted incidence of about 1.04–1.9 per 1000 person-years that rises dramatically with increasing age [1–4]. Active malignancy accounts for almost 20% of incident VTE events occurring in the community [5], and imparts a 4- to 6.5-fold higher VTE risk compared to non-cancer patients, depending on concurrent use of anti-cancer therapy [6]. The risk of VTE also varies by cancer type and stage [7–10]. The association between VTE and malignancy has been recognized since 1861 when Trousseau, in a lecture, described thrombophlebitis as the presenting sign of visceral malignancy [11].

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  1. Division of Hematology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA

    Aneel A. Ashrani

  2. Dept of Hematology Research, Mayo Clinic, 200 First St SW,Stabile 6-60, Rochester, MN 55905, USA

    John A. Heit

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    Ashrani, A.A., Heit, J.A. (2009). Risk Factors for Thrombosis in Cancer Patients. In: Kwaan, H., Green, D. (eds) Coagulation in Cancer. Cancer Treatment and Research, vol 148. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79962-9_7

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