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Cyclin-Dependent Kinase 5 and Insulin Secretion

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Book cover Cyclin Dependent Kinase 5 (Cdk5)

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Abstract

Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood. The final biochemical events leading to insulin release from the β-cell are governed by a secretion apparatus that is similar to the presynaptic machinery mediating synaptic transmission in neuronal networks. We now summarize recent developments in the field of Cdk5 and regulated exocytosis and also present some novel findings regarding Cdk5’s effect on insulin secretion.

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Acknowledgments

Our own work presented here has been supported by funding to one or more of the authors by the following grant agencies, to which we are sincerely thankful: The Swedish Research Council, The Family Erling-Persson Foundation, The Novo Nordisk Foundation, Berth von Kantzow's Foundation, Funds from Karolinska Institutet, The Swedish Diabetes Association, EFSD, Eurodia and The Slovenian Research Agency.

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Authors and Affiliations

  1. The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden

    Christina Bark

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  1. Christina Bark
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  2. Marjan Rupnik
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  3. Marko Jevsek
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  4. Slavena A. Mandic
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  5. Per-Olof Berggren
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Correspondence to Christina Bark .

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Editors and Affiliations

  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Bark, C., Rupnik, M., Jevsek, M., Mandic, S.A., Berggren, PO. (2008). Cyclin-Dependent Kinase 5 and Insulin Secretion. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_11

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