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Dendritic Organelles for Postsynaptic Trafficking

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Book cover Structural And Functional Organization Of The Synapse

Abstract

The development, maintenance, and plasticity of synapses require the trafficking of molecular components to postsynaptic specializations distributed across elaborate dendritic arbors. The large size and geometric complexity of dendrites necessitate specialized mechanisms that can both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in neuronal development and synaptic plasticity, the cellular rules governing postsynaptic trafficking are only now emerging. We review here current knowledge on the organization of dendritic organelles, and describe cell biological mechanisms that allow long-range transport of postsynaptic components that are then locally processed at individual synapses.

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    Cyril Hanus & Michael D. Ehlers

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Hanus, C., Ehlers, M.D. (2008). Dendritic Organelles for Postsynaptic Trafficking. In: Hell, J.W., Ehlers, M.D. (eds) Structural And Functional Organization Of The Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77232-5_8

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