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Reelin and Cyclin-Dependent Kinase 5

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Reelin Glycoprotein

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Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter, I shall describe the functions of Cdk5 in neuronal migration during brain development and present an overview of the relationship of Cdk5 with Reelin signaling based on analyses of mutant mouse models. I shall also refer to the functions of Reelin signaling and Cdk5 in dendrite development, synaptic plasticity, and neurodegeneration.

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Authors and Affiliations

  1. Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan

    Toshio Ohshima

  2. Laboratory for Molecular Brain Science, Department of Life Science and Medical Bio-Science, Waseda University, Sinjuku, Tokyo, 169-8555, Japan

    Toshio Ohshima

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  1. Medical School, University of Minnesota, Minneapolis, MN, USA

    S. Hossein Fatemi M.D., Ph.D. (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience) (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience)

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Ohshima, T. (2008). Reelin and Cyclin-Dependent Kinase 5. In: Fatemi, S.H. (eds) Reelin Glycoprotein. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76761-1_9

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