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Reelin Glycoprotein pp 15–35Cite as

Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview

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It is now well established that members of the low-density lipoprotein (LDL) receptor gene family are crucial regulators of different aspects of neuronal development, synaptic plasticity, maintenance of neuronal homeostasis, and neurodegeneration. This was highlighted in particular by the discovery that the lipoprotein receptors apolipoprotein E receptor-2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR) function as receptors for the neuronal signaling protein Reelin. In this chapter, we will briefly introduce the family of LDL receptor-related proteins and review the functions of its members ApoER2 and VLDLR as Reelin receptors and their role in the developing and adult brain.

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Authors and Affiliations

  1. Zentrum für Neurowissenschaften, Universität Freiburg, Albertstrasse 23, 79104, Freiburg, Germany

    Hans H. Bock & Joachim Herz

  2. Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390

    Joachim Herz

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  1. Hans H. Bock
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  1. Medical School, University of Minnesota, Minneapolis, MN, USA

    S. Hossein Fatemi M.D., Ph.D. (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience) (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience)

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Bock, H.H., Herz, J. (2008). Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview. In: Fatemi, S.H. (eds) Reelin Glycoprotein. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76761-1_2

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