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An Evidence-Based Approach to Glaucoma Care

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Abstract

Put several glaucoma specialists in a room and solicit opinions on just about any clinical issue and you are bound to receive multiple opinions on how to manage the problem. For example, a patient presents with shallow angles on van Herrick screening. What gonioscopic features would prompt you to perform a laser iridotomy? Would you perform a dark room provocative test to confirm your impression that the angle was potentially occludable? Do you perform a pharmacological challenge test before proceeding to prophylactic laser iridotomy? Would you order an ultrasound biomicroscopic test to confirm your impression? If you do decide that prophylactic laser iridotomy is indicated, what is the best surgical technique for achieving patency? Is there evidence to support a “best approach” to the patient with the narrow angle? In this chapter, we discuss how evidence-based medicine (EBM) can be used to provide the very best answers to questions such as these. This approach can be applied not only to glaucoma problems, but also to any clinical problem in medicine.

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References

  1. The reliable source of evidence in health care. In: Julian PT, Higgins, Sally, eds. The Cochrane Handbook for Systematic Reviews of Interventions. Wiley, Interscience, Sussex England; 2008.

    Google Scholar 

  2. Bhandari M, Zlowodzki M, Cole PA. From eminence-based practice to evidence-based practice: a paradigm shift. Minn Med. 2004;87:51–54.

    PubMed  Google Scholar 

  3. Gorman C. Are doctors just playing hunches? Time. 2007;169(9):52–54.

    PubMed  Google Scholar 

  4. Gordon MO, Beiser JA, Brandt JD, et al. The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714-720. discussion 829–830.

    PubMed  Google Scholar 

  5. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008;115:85–93.

    Article  PubMed  Google Scholar 

  6. Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ. 1996;312:71–72.

    CAS  PubMed  Google Scholar 

  7. Flynn CA, D’Amico F, Smith G. Should we patch corneal abrasions? A meta-analysis. J Fam Pract. 1998;47:264–270.

    CAS  PubMed  Google Scholar 

  8. Michael JG, Hug D, Dowd MD. Management of corneal abrasion in children: a randomized clinical trial. Ann Emerg Med. 2002;40:67–72.

    Article  PubMed  Google Scholar 

  9. Le Sage N, Verreault R, Rochette L. Efficacy of eye patching for traumatic corneal abrasions: a controlled clinical trial. Ann Emerg Med. 2001;38:129–134.

    Article  PubMed  Google Scholar 

  10. Daly WJ, Brater DC. Medieval contributions to the search for truth in clinical medicine. Perspect Biol Med. 2000;43:530–540.

    CAS  PubMed  Google Scholar 

  11. North R. Benjamin Rush, MD: assassin or beloved healer? Proc (Bayl Univ Med Cent). 2000;13:45–49.

    CAS  Google Scholar 

  12. Bean RB. Sir William Osler. Aphorisms. Springfield: Blackwell; 1961:164

    Google Scholar 

  13. Morris JN. Recalling the miracle that was penicillin: two memorable patients. J R Soc Med. 2004;97:189–190.

    Article  CAS  PubMed  Google Scholar 

  14. Mansberger SL. A risk calculator to determine the probability of glaucoma. J Glaucoma. 2004;13:345–347.

    Article  PubMed  Google Scholar 

  15. Medeiros FA, Weinreb RN, Sample PA, et al. Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma. Arch Ophthalmol. 2005;123:1351–1360.

    Article  PubMed  Google Scholar 

  16. Gordon MO, Torri V, Miglior S, et al. Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. Ophthalmology. 2007;114:10–19.

    Article  PubMed  Google Scholar 

  17. von Helmholtz HLF. Beschreibung eines Augen-Spiegels. Berlin, Germany: A Förstner'sche Verlagsbuchhandlung; 1851.

    Google Scholar 

  18. Dellaporta A. Historical notes on gonioscopy. Surv Ophthalmol. 1975;20:137–149.

    Article  CAS  PubMed  Google Scholar 

  19. Hertzog LH, Albrecht KG, LaBree L, Lee PP. Glaucoma care and conformance with preferred practice patterns. Examination of the private, community-based ophthalmologist. Ophthalmology. 1996;103:1009–1013.

    CAS  PubMed  Google Scholar 

  20. Coleman AL, Yu F, Evans SJ. Use of gonioscopy in medicare beneficiaries before glaucoma surgery. J Glaucoma. 2006;15:486–493.

    Article  PubMed  Google Scholar 

  21. Kronfeld P. Eserine and pilocarpine: our 100-year-old allies. Surv Ophthalmol. 1970;14:479.

    CAS  PubMed  Google Scholar 

  22. Beasley H, Fraunfelder FT. Retinal detachments and topical ocular miotics. Ophthalmology. 1979;86:95–98.

    CAS  PubMed  Google Scholar 

  23. Zimmerman TJ, Kass MA, Yablonski ME, Becker B. Timolol maleate: efficacy and safety. Arch Ophthalmol. 1979;97:656–658.

    CAS  PubMed  Google Scholar 

  24. Lippa EA, Carlson LE, Ehinger B, et al. Dose response and duration of action of dorzolamide, a topical carbonic anhydrase inhibitor. Arch Ophthalmol. 1992;110:495–499.

    CAS  PubMed  Google Scholar 

  25. Derick RJ, Robin AL, Walters TR, et al. Brimonidine tartrate: a one-month dose response study. Ophthalmology. 1997;104:131–136.

    CAS  PubMed  Google Scholar 

  26. Camras CB, Schumer RA, Marsk A, et al. Intraocular pressure reduction with PhXA34, a new prostaglandin analogue, in patients with ocular hypertension. Arch Ophthalmol. 1992;110:1733–1738.

    CAS  PubMed  Google Scholar 

  27. Eddy DM, Billings J. The quality of medical evidence: implications for quality of care. Health Aff (Millwood). 1988;7:19–32.

    Article  CAS  Google Scholar 

  28. Kass MA, Heuer DK, Higginbotham EJ, et al. The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:701-713. discussion 829–830.

    PubMed  Google Scholar 

  29. Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002;120:1268–1279.

    PubMed  Google Scholar 

  30. The Glaucoma Laser Trial (GLT). 2. Results of argon laser trabeculoplasty versus topical medicines. The Glaucoma Laser Trial Research Group. Ophthalmology 1990;97:1403–1413

    Google Scholar 

  31. Lichter PR, Musch DC, Gillespie BW, et al. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology. 2001;108:1943–1953.

    Article  CAS  PubMed  Google Scholar 

  32. Denis P, Lafuma A, Khoshnood B, Mimaud V, Berdeaux G. A meta-analysis of topical prostaglandin analogues intra-ocular pressure lowering in glaucoma therapy. Curr Med Res Opin. 2007;23:601–608.

    Article  CAS  PubMed  Google Scholar 

  33. Cheng JW, Wei RL. Meta-analysis of 13 randomized controlled trials comparing bimatoprost with latanoprost in patients with elevated intraocular pressure. Clin Ther. 2008;30:622–632.

    Article  CAS  PubMed  Google Scholar 

  34. Vass C, Hirn C, Sycha T, Findl O, Bauer P, and Schmetterer L. Medical interventions for primary open angle glaucoma and ocular hypertension. Cochrane Database Syst Rev 2007:CD003167

    Google Scholar 

  35. Kuhn TS. The structure of scientific revoluations, 3rd ed. Chicago: The University of Chicago Press; 1996:212

    Google Scholar 

  36. Konstas AG, Kozobolis VP, Katsimpris IE, et al. Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients. Ophthalmology. 2007;114:653–657.

    Article  PubMed  Google Scholar 

  37. Konstas AG, Hollo G, Irkec M, et al. Diurnal IOP control with bimatoprost versus latanoprost in exfoliative glaucoma: a crossover, observer-masked, three-centre study. Br J Ophthalmol. 2007;91:757–760.

    Article  CAS  PubMed  Google Scholar 

  38. Parmaksiz S, Yuksel N, Karabas VL, Ozkan B, Demirci G, Caglar Y. A comparison of travoprost, latanoprost, and the fixed combination of dorzolamide and timolol in patients with pseudoexfoliation glaucoma. Eur J Ophthalmol. 2006;16:73–80.

    CAS  PubMed  Google Scholar 

  39. Konstas AG, Mylopoulos N, Karabatsas CH, et al. Diurnal intraocular pressure reduction with latanoprost 0.005% compared to timolol maleate 0.5% as monotherapy in subjects with exfoliation glaucoma. Eye 2004;18:893–899

    Article  CAS  PubMed  Google Scholar 

  40. Konstas AG, Kozobolis VP, Tersis I, Leech J, Stewart WC. The efficacy and safety of the timolol/dorzolamide fixed combination vs latanoprost in exfoliation glaucoma. Eye. 2003;17:41–46.

    Article  CAS  PubMed  Google Scholar 

  41. Barratt A, Wyer PC, Hatala R, et al. Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat. CMAJ. 2004;171:353–358.

    PubMed  Google Scholar 

  42. Higginbotham EJ, Gordon MO, Beiser JA, et al. The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch Ophthalmol. 2004;122:813–820.

    Article  PubMed  Google Scholar 

  43. Musch DC, Gillespie BW, Niziol LM, et al. Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes. Arch Ophthalmol. 2006;124:1694–1700.

    Article  PubMed  Google Scholar 

  44. Pasquale LR, Dolgitser M, Wentzloff JN, et al. Health care charges for patients with ocular hypertension or primary open-angle glaucoma. Ophthalmology. 2008;115(4):633–638.

    Article  PubMed  Google Scholar 

  45. Kymes SM, Kass MA, Anderson DR, Miller JP, Gordon MO. Management of ocular hypertension: a cost-effectiveness approach from the Ocular Hypertension Treatment Study. Am J Ophthalmol. 2006;141:997–1008.

    Article  PubMed  Google Scholar 

  46. Speaker MG, Guerriero PN, Met JA, Coad CT, Berger A, Marmor M. A case-control study of risk factors for intraoperative suprachoroidal expulsive hemorrhage. Ophthalmology. 1991;98:202-209. discussion 210.

    CAS  PubMed  Google Scholar 

  47. Obuchowska I, Mariak Z. Risk factors of massive suprachoroidal hemorrhage during extracapsular cataract extraction surgery. Eur J Ophthalmol. 2005;15:712–717.

    CAS  PubMed  Google Scholar 

  48. Moshfeghi DM, Kim BY, Kaiser PK, Sears JE, Smith SD. Appositional suprachoroidal hemorrhage: a case-control study. Am J Ophthalmol. 2004;138:959–963.

    Article  PubMed  Google Scholar 

  49. Ehlers JP, Spirn MJ, Lam A, Sivalingam A, Samuel MA, Tasman W. Combination intravitreal bevacizumab/panretinal photocoagulation versus panretinal photocoagulation alone in the treatment of neovascular glaucoma. Retina. 2008;28:696–702.

    Article  PubMed  Google Scholar 

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Pasquale, L.R. (2010). An Evidence-Based Approach to Glaucoma Care. In: Schacknow, P., Samples, J. (eds) The Glaucoma Book. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76700-0_2

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  • DOI: https://doi.org/10.1007/978-0-387-76700-0_2

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