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Charge Modification of Pharmaceutical Nanocarriers: Biological Implications

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Multifunctional Pharmaceutical Nanocarriers

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 4))

Multifunctional particles may be necessary to target specific locations and overcome different barriers hampering the delivery of drugs using nanoparticulate matter (Fenart et al. 1999; Kreuter 2004; Lockman et al. 2004). The interaction taking place is based on several properties that are essential for the relation between particle and biological system. For instance, the multifunctional particles will allow to target a certain tissue, deliver an active component, and provide a marker to observe the successful delivery (McNeil 2005).

In this chapter we will focus on the charge as one of the most basic and crucial properties influencing the environmental interaction of nanoparticulate matter. The surface charge of the nanoscale particles is a standard parameter to be characterized and reported. This is attributed to the stability of the suspension, which is achieved by electrostatic repulsion or, less often, by sterical hindrance. Charge is mainly used for complexation. Especially, this holds for the intracellular delivery of genetic material (RNA, DNA, and oligonucleotides), which is typically negatively charged and therefore requires a positively charged carrier (Elouahabi and Ruysschaert 2005).

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  1. Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66041, Saarbrücken, Germany

    N. Nafee

  2. Institute of Biopharmaceutics, Saarland University, 66041, Saarbrücken, Germany

    M. Schneider & C. -M. Lehr

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    Vladimir Torchilin

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Nafee, N., Schneider, M., Lehr, C.M. (2008). Charge Modification of Pharmaceutical Nanocarriers: Biological Implications. In: Torchilin, V. (eds) Multifunctional Pharmaceutical Nanocarriers. Fundamental Biomedical Technologies, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76554-9_11

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