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Molecular Oncogenesis of Lung Cancer

  • Chapter
Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

In 2005, cancer surpassed heart disease as the leading cause for death in Americans under the age of 80 years. Among all types of human cancer, lung cancer is the leading cause of cancer-related death, claiming more than 150,000 lives every year in the United States alone (which exceeds the combined mortality from breast, prostate, colorectal, and pancreatic cancers). Patients with advanced stages of lung cancer, representing 75% of all new cases, have a median survival time of only 10 months.1 In contrast to the significant medical burden associated with lung cancer, research on lung cancer is underfunded. According to National Institutes of Health data (http://planning.cancer.gov/disease), the U.S. government spent approximately $1,200 per lung cancer death in 2002 on research compared with $11,425 for breast cancer, $8,190 for prostate cancer, and $3,350 for colorectal cancer. Approximately $31,000 was spent on research per HIV/AIDS death in 2002. Understanding the molecular basis of lung cancer progression and tumor metastasis is an essential step to reducing the mortality from lung cancer.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA

    Arwen A. Stelter BS (Graduate Assistant) & Jingwu Xie PhD (Associate Professor)

Authors
  1. Arwen A. Stelter BS
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  2. Jingwu Xie PhD
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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© 2008 Springer Science+Business Media, LLC.

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Stelter, A.A., Xie, J. (2008). Molecular Oncogenesis of Lung Cancer. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_16

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-72429-4

  • Online ISBN: 978-0-387-72430-0

  • eBook Packages: MedicineMedicine (R0)

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