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Mechanisms of Insulin Action pp 168–184Cite as

Transgenic Models of Impaired Insulin Signaling

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Abstract

Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension and cardiovascular diseases. The predisposition to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in rodents, investigators have developed mouse models to test critical hypotheses on the pathogenesis of insulin resistance. Moreover, experimental crosses among mutant mice have shed light onto the polygenic nature of the interactions underlying this complex metabolic condition. This review focuses on targeted mutations affecting the function of genes in the insulin signaling pathway in mice.

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  1. Berrie Research Pavilion, 1150 St. Nicholas Ave., New York, New York, 10032, USA

    Domenico Accili

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  1. Francesco Oriente
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  2. Domenico Accili
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© 2007 Landes Bioscience and Springer Science+Business Media

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Oriente, F., Accili, D. (2007). Transgenic Models of Impaired Insulin Signaling. In: Mechanisms of Insulin Action. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72204-7_9

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  • DOI: https://doi.org/10.1007/978-0-387-72204-7_9

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