Skip to main content

Invasion and Dissemination of Yersinia enterocolitica in the Mouse Infection Model

  • Chapter
The Genus Yersinia

Part of the book series: Advances In Experimental Medicine And Biology ((AEMB,volume 603))

Yersinia enterocolitica is one of the most common causes of food borne gastrointestinal disease. After oral uptake yersiniae replicate in the small intestine, invade Peyeŕs patches of the distal ileum and disseminate to spleen and liver. In these tissues and organs yersiniae replicate extracellularly and form exclusively monoclonal microabscesses. Only very few yersiniae invade Peyeŕs patches and establish just a very few monoclonal microabscesses. This is due to both Yersinia and host specific factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Autenrieth, I.B., Vogel, U., Preger, S., Heymer, B. and Heesemann, J. (1993) Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response. Infect. Immun. 61, 2585-2595.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Barnes, P.D., Bergman, M.A., Mecsas, J. and Isberg, R.R. (2006) Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J. Exp. Med. 203, 1591-1601.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bottone, E.J. (1997) Yersinia enterocolitica: the charisma continues. Clin. Microbiol. Rev. 10, 257-276.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Carter, P.B. (1975) Pathogenecity of Yersinia enterocolitica for mice. Infect. Immun. 11, 164-170.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Clark, M.A., Hirst, B.H. and Jepson, M.A. (1998) M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer’s patch M cells. Infect. Immun. 66, 1237-1243.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Clark, M.A. and Jepson, M.A. (2003) Intestinal M cells and their role in bacterial infection. Int. J. Med. Microbiol. 293, 17-39.

    Article  CAS  PubMed  Google Scholar 

  • Conlan, J.W. (1997) Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia en-terocolitica. Infect. Immun. 65, 630-635.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Eitel, J. and Dersch, P. (2002) The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed. Infect. Immun. 70, 4880-4891.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grutzkau, A., Hanski, C., Hahn, H. and Riecken, E.O. (1990) Involvement of M cells in the bacterial invasion of Peyer’s patches: a common mechanism shared by Yersinia enterocoli-tica and other enteroinvasive bacteria. Gut 31, 1011-1015.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hamburger, Z.A., Brown, M.S., Isberg, R.R. and Bjorkman, P.J. (1999) Crystal structure of invasin: a bacterial integrin-binding protein. Science 286, 291-295.

    Article  CAS  PubMed  Google Scholar 

  • Handley, S.A., Newberry, R.D. and Miller, V.L. (2005) Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination. Infect. Im-mun. 73, 8453-8455.

    Article  CAS  Google Scholar 

  • Hanski, C., Kutschka, U, Schmoranzer, H.P., Naumann, M., Stallmach, A., Hahn, H., Menge, H. and Riecken, E.O. (1989) Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis. Infect. Immun. 57, 673-678.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Heesemann, J., Sing, A. and Trülzsch, K. (2006) Yersinia’s stratagem: targeting innate and adaptive immune defense. Curr. Opin. Microbiol 9, 55-61.

    Article  CAS  PubMed  Google Scholar 

  • Heise, T. and Dersch, P. (2006) Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake. Proc. Natl. Acad. Sci. USA 103, 3375-3380.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Isberg, R.R. and Barnes, P. (2001) Subversion of integrins by enteropathogenic Yersinia. J. Cell. Sci. 114, 21-28.

    CAS  PubMed  Google Scholar 

  • Isberg, R.R. and Leong, J.M. (1990) Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell 60, 861-871.

    Article  CAS  PubMed  Google Scholar 

  • Leong, J.M., Fournier, R.S. and Isberg, R.R. (1990) Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J. 9, 1979-1989.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marra, A. and Isberg, R.R. (1996) Analysis of the role of invasin during Yersinia pseudotu-berculosis infection of mice. Ann. N.Y. Acad. Sci. 797, 290-292.

    Article  CAS  PubMed  Google Scholar 

  • Mecsas, J., Bilis, I. and Falkow, S. (2001) Identification of attenuated Yersinia pseudotubercu-losis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis. Infect. Immun. 69, 2779-2787.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oellerich, M., Jacobi, C., Freund, S., Niedung, K., Bach, A., Heesemann, J. and Trülzsch, K. (2007) Yersinia enterocolitica infection of mice reveals clonal invasion and abscess for-mation. submitted for publication.

    Google Scholar 

  • Pepe, J.C., Badger, J.L. and Miller, V.L. (1994) Growth phase and low pH affect the thermal regulation of the Yersinia enterocolitica inv gene. Mol. Microbiol 11, 123-135.

    Article  CAS  PubMed  Google Scholar 

  • Pepe, J.C. and Miller, V.L. (1993) Yersinia enterocolitica invasin: a primary role in the initia-tion of infection. Proc. Natl. Acad. Sci. USA 90,6473-6477.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simonet, M., Richard, S. and Berche, P. (1990) Electron microscopic evidence for in vivo extracellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid. In-fect. Immun. 58, 841-845.

    CAS  Google Scholar 

  • Trülzsch, K., Sporleder, T., Igwe, E.I., Russmann, H. and Heesemann, J. (2004) Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse in-fection model. Infect. Immun. 72, 5227-5234.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vazquez-Torres, A., Jones-Carson, J., Baumler, A.J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W.T. and Fang, F.C. (1999) Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature 401, 804-808.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Trülzsch, K., Heesemann, J., Oellerich, M.F. (2007). Invasion and Dissemination of Yersinia enterocolitica in the Mouse Infection Model. In: Perry, R.D., Fetherston, J.D. (eds) The Genus Yersinia. Advances In Experimental Medicine And Biology, vol 603. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72124-8_25

Download citation

Publish with us

Policies and ethics