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Heat Shock Proteins and the Regulation of Apoptosis

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Heat Shock Proteins in Neural Cells

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

Abstract

Since the elucidation of their functions in protein folding and translocation, heat shock protein chaperones have been a target of research in all spheres of biomedicine. Within the last five years, research efforts have intensified, following the discovery of raised levels of heat shock protein (Hsp) expression in the brains of patients suffering from many neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s diseases and cerebral ischaemia. Expression of Hsps in the brains of patients is thought to form part of a general protective stress response. The stress in question, however, varies, depending on the particular disease. For example, accumulation of α-synuclein aggregates in Parkinson’s Disease causes stress to the protein folding machinery of the cells, with consequent up-regulation of stress proteins including Hsps. When markers indicative of the occurrence of apoptosis were also found in degenerating brain tissue, the question of how heat shock proteins might impact on apoptotic neural cells was raised. However, their particular function under diseased conditions remains unclear. This chapter highlights the involvement of Hsps in the regulation of neural apoptosis, from the original reports of Hsp expression during neurological disorders, to evidence of their neuroprotective properties and their potential as therapeutic molecules.

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Authors and Affiliations

  1. NCBES, National University of Ireland, Galway, University Road, Galway, Ireland

    Una FitzGerald & Afshin Samali

  2. Department of Biochemistry, National University of Ireland, Galway, Ireland

    Adrienne M. Gorman

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  1. Una FitzGerald
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Correspondence to Afshin Samali .

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FitzGerald, U., Gorman, A.M., Samali, A. (2009). Heat Shock Proteins and the Regulation of Apoptosis. In: Heat Shock Proteins in Neural Cells. Neuroscience Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39954-6_5

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