Abstract
Nonhuman primates have proven to be valuable models in the study of seasonal and highly pathogenic influenza virus infections, prophylaxis, and therapy. Due to their close genetic relationship to humans, these animals share anatomic, postural, physiological, and immune features with us of key importance when it comes to progression and mitigation of respiratory infections. Their lower susceptibility to natural influenza infection even presents an advantage in the laboratory setting because of the need for immunologically naïve animals, and since nonhuman primates are relatively genetically diverse within one species, their study provides an essential complement to the body of knowledge acquired with inbred animal models. However, ethical and cost considerations typically result in smaller experiments and a need to look at additional levels of biological information in order to maximize insights gained from these studies. Systems biology is a powerful tool for this purpose, because it provides a much needed wide angle view of complex interactions taking places in organisms which are more than the sum of their parts. This chapter will describe the extent to which functional genomics and proteomics have successfully integrated with other, more traditional tools in the areas of clinical presentation, pathology, and immunology during influenza infections in nonhuman primates. It will also describe the unique contributions systems biology has made to our understanding of host–virus interactions, as well as response to vaccination and antiviral therapy.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Baas T, Baskin CR, Diamond DL, García-Sastre A, Bielefeldt-Ohmann H, Tumpey TM, Thomas MJ et al (2006) Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics. J Virol 80(21):10813–10828. doi:10.1128/JVI.00851-06
Baskin Carole R, Bielefeldt-Ohmann H, Tumpey TM, Sabourin PJ, Long JP, García-Sastre A, Tolnay A-E, et al (2009) Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A 106(9):3455–3460 National Academy of Sciences http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2642661&tool=pmcentrez&rendertype=abstract
Baskin Carole R, Katze MG (2008) Systems biology could help us understand protect against pandemics. Microbe 3(5):227–233
Baskin CR, García-Sastre A, Tumpey TM, Bielefeldt-Ohmann H, Carter VS, Nistal-Villán E, Katze MG (2004) Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina). J Virol 78(19):10420–10432 American Society for Microbiology http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15367608
Bouvier NM, Lowen AC (2010) Animal models for influenza virus pathogenesis and transmission. Viruses 2(8):1530–1563. doi:10.3390/v20801530
Brown KL, Cosseau C, Gardy JL, Hancock REW (2007) Complexities of targeting innate immunity to treat infection. Trend Immunol 28(6):260–266. http://www.ncbi.nlm.nih.gov/pubmed/17468048
Brown JN, Palermo RE, Baskin CR, Gritsenko M, Sabourin PJ, Long JP, Sabourin CL et al (2010) Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections. J Virol 84(22):12058–12068, American Society for Microbiology (ASM). http://www.ncbi.nlm.nih.gov/pubmed/20844032
Butcher EC (2005) Can cell systems biology rescue drug discovery? Nat Rev Drug Discov 4(6):461–467. http://www.ncbi.nlm.nih.gov/pubmed/17249501
Chen Y, Deng W, Jia C, Dai X, Zhu H, Kong Q, Huang L et al (2009) Pathological lesions and viral localization of influenza A (H5N1) virus in experimentally infected Chinese rhesus macaques: implications for pathogenesis and viral transmission. Arch Virol 154(2):227–233. http://www.ncbi.nlm.nih.gov/pubmed/19130169
Cillóniz C, Shinya K, Peng X, Korth MJ, Proll SC, Aicher LD, Carter VS et al (2009) Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. (MS. Diamond, Ed.)PLoS Pathog 5(10):12, Public Library of Science http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2745659&tool=pmcentrez&rendertype=abstract
Food and Drug Administration (2012) Challenge and opportunity on the critical path to new medical products. www.fda.gov/downloads_ScienceResearch_SpecialTopics_CriticalPathInitiative_CriticalPathOpportunitiesReports_ucm113411. Accessed May 31 2012
Gardy JL, Lynn DJ, Brinkman FSL, Hancock REW (2009) Enabling a systems biology approach to immunology: focus on innate immunity. Trend Immunol 30(6):249–262 http://www.ncbi.nlm.nih.gov/pubmed/19428301
Hood L (2011) Lee Hood. Nat Biotechnol 29(3):191 http://www.ncbi.nlm.nih.gov/pubmed/21390010
Jenner R, Young R (2005) Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol 3(4):281–294 http://discovery.ucl.ac.uk/93597/
Jones-Engel L, Engel GA, Schillaci MA, Babo R, Froehlich J (2001) Detection of antibodies to selected human pathogens among wild and pet macaques (Macaca tonkeana) in Sulawesi Indonesia. Am J Primatol 54(3):171–178. doi:10.1002/ajp.1021
Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y et al (2007) Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445(7125):319–323. doi:10.1038/nature05495
Kochs G, García-Sastre A, Martínez-Sobrido L (2007) Multiple anti-interferon actions of the influenza a virus NS1 protein. J Virol 81(13):7011–7021 American Society for Microbiology http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1933316&tool=pmcentrez&rendertype=abstract
Loo YM, Gale M (2007) Influenza: fatal immunity and the 1918 virus. Nature 445(7125):267–268
Pennings JLA, Kimman TG, Janssen R (2008) Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques. (N. Papavasiliou, Ed.) PLoS ONE 3(7):7 Public Library of Science http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2442866&tool=pmcentrez&rendertype=abstract
Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, Wittkowski KM et al (2007) Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood 109(5):2066–2077 American Society of Hematology http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1801073&tool=pmcentrez&rendertype=abstract
Rimmelzwaan GF, Kuiken T, Van Amerongen G, Bestebroer TM, Fouchier RAM, Osterhaus ADME (2001). Pathogenesis of influenza A (H5N1) virus infection in a primate model. J Virol 75(14):6687–6691 American Society for Microbiology http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11413336
Shapira SD, Hacohen N (2011) Systems biology approaches to dissect mammalian innate immunity. Curr Opin Immunol 23(1):71–77 Elsevier Ltd. http://www.ncbi.nlm.nih.gov/pubmed/21111589
Shinya K, Gao Y, Cilloniz C, Suzuki Y, Fujie M, Deng G, Zhu Q et al (2012) Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. J Virol. doi:10.1128/JVI.00365-12
Tolnay, A-E, Baskin CR, Tumpey TM, Sabourin PJ, Sabourin CL, Long JP, Pyles JA et al (2010) Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus. Arch Virol 155(6):905-914 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20372944
Trautmann L, Sekaly R-P (2011) Solving vaccine mysteries: a systems biology perspective. Nat Immunol. doi:10.1038/ni.2078 Nature Publishing Group
Baskin CR, Bielefeldt-Ohmann H, García-Sastre A, Tumpey, TM, Van Hoeven N, Carter VS, Thomas MJ, et al (2007) Functional genomic and serological analysis of the protective immune response resulting from Vaccination of macaques with an NS1-truncated influenza virus. J Virol 81(21):11817–11827 Am Soc Microbiol (ASM) http://www.ncbi.nlm.nih.gov/pubmed/17715226
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Baskin, C. (2012). The Role and Contributions of Systems Biology to the Non-Human Primate Model of Influenza Pathogenesis and Vaccinology. In: Katze, M. (eds) Systems Biology. Current Topics in Microbiology and Immunology, vol 363. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_248
Download citation
DOI: https://doi.org/10.1007/82_2012_248
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-33098-8
Online ISBN: 978-3-642-33099-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)