Abstract
Given the rapid rate of population aging, basic science and public health efforts have increasingly focused on the determinants of successful cognitive aging. In this chapter, we review the definition and biological, psychological, and environmental determinants of cognitive health in later life. Successful cognitive aging is a multi-dimensional construct that lacks a consensus operationalized definition, and has been variously conceptualized in an ipsative, normative, or criterion-referenced manner. Nevertheless, there are a number of biomarkers, at the genetic and cellular level, that provide indicators of cognitive health in aging. Functional and structural neuroimaging suggest multiple pathways to successful cognitive aging, by way of brain reserve and cognitive reserve. A number of behavioral and environmental interventions, including dietary restriction, physical activity, and cognitive stimulation, are promising avenues for extending the cognitive healthspan associated with normal aging. Thus, there is a variety of recent findings providing optimism that successful cognitive aging, howsoever defined, will be attainable by more older adults in the future.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ardelt M (1997) Wisdom and life satisfaction in old age. J Gerontol B Psychol Sci Soc Sci 52(1):P15–P27
Atzmon G, Cho M et al (2010) Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Nat Acad Sci U S A 107:1710–1717
Aviv A, Levy D et al (2003) Growth, telomere dynamics and successful and unsuccessful human aging. Mech Ageing Dev 124(7):829–837
Cabeza R, Anderson ND et al (2002) Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage 17(3):1394–1402
Colcombe SJ, Erickson KI et al (2006) Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 61(11):1166–1170
Cotman CW, Berchtold NC (2002) Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 25(6):295–301
Daffner KR (2010) Promoting successful cognitive aging: a comprehensive review. J Alzheimer’s Dis 19(4):1101–1122
Depp CA, Schkade DA et al (2010) Age, affective experience, and television use. Am J Prev Med 39(2):173–178
Depp CA, Jeste DV (2006) Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry 14(1):6–20
Dickinson D, Ramsey ME et al (2007) Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in Schizophrenia. Arch Gen Psychiatry 64(5):532–542
Finkel D, Pedersen NL et al (1998) Longitudinal and cross-sectional twin data on cognitive abilities in adulthood: the Swedish adoption/twin study of aging. Dev Psychol 34(6):1400–1413
Fogel RW (2005) Changes in the physiology of aging during the twentieth century. NBER work paper series w 11233, National Bureau of Economic Research, Cambridge
Fontana L, Partridge L et al (2010) Extending healthy life span—from yeast to humans. Science 328(5976):321–326
Freud S (1924) On psychotherapy. Hogarth Press, London
Geda YE, Roberts RO et al (2010) Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol 67(1):80–86
Glatt SJ, Chayavichitsilp P et al (2007) Successful aging: from phenotype to genotype. Biol Psychiatry 62(4):282–293
Gurland BJ, Page WF et al (2004) A twin study of the genetic contribution to age-related functional impairment. J Gerontol A Biol Sci Med Sci 59(8):859–863
Haan MN, Shemanski L et al (1999) The role of APOE Ïμ4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA J Am Med Assoc 282(1):40–46
Han L, McCusker J et al (2006) The temporal relationship between depression symptoms and cognitive functioning in older medical patients—prospective or concurrent? J Gerontol A Biol Sci Med Sci 61(12):1319–1323
Hendrie H, Albert M et al (2006) The NIH cognitive and emotional health project: report of the critical evaluation study committee. Alzheimer’s Dementia J Alzheimer’s Assoc 2(1):12–32
Jeste DV, Ardelt M et al (2010) Expert consensus on characteristics of wisdom: a Delphi method study. Gerontologist 50(5):668–680
Jeste DV, Vahia IV (2008) Comparison of the conceptualization of wisdom in ancient Indian literature with modern views: focus on the Bhagavad Gita. Psychiatry 71(3):197–209
Karel MJ (1997) Aging and depression: vulnerability and stress across adulthood. Clin Psychol Rev 17(8):847
Kramer AF, Erickson KI et al (2006) Exercise, cognition, and the aging brain. J Appl Physiol 101(4):1237–1242
Lamond AJ, Depp CA et al (2008) Measurement and predictors of resilience among community-dwelling older women. J Psychiatr Res 43(2):148–154
Larson EB, Wang L (2004) Exercise, aging, and Alzheimer disease. Alzheimer Dis Assoc Disord 18(2):54–56
Mahncke HW, Connor BB et al (2006) Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A 103(33):12523–12528
Malaspina L, Woods SP et al (2011) Successful cognitive aging in persons living with HIV infection. J Neurovirol 17(1):110–119
Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurosci 7(4):278–294
McEwen BS (2000) Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity. Neurochem Res 25(9–10):1219–1231
McGeer EG, McGeer PL (2003) Inflammatory processes in Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry 27(5):741–749
Meeks TW, Vahia IV et al (2011) A tune in “a minor” can “b major”: a review of epidemiology, illness course, and public health implications of subthreshold depression in older adults. J Affect Disord 129(1–3):126–142
Meeks TW, Jeste DV (2009) Neurobiology of wisdom: a literature overview. Arch Gen Psychiatry 66(4):355–365
National Institute on Aging (2007) Why population aging matters: a global perspective. National Institute on Aging, Bethesda
O’Hara R, Hallmayer JF (2007) Serotonin transporter polymorphism and stress: a view across the lifespan. Curr Psychiatry Rep 9(3):173–175
Palmer B, Dawes S et al (2009) What do we know about neuropsychological aspects of Schizophrenia? Neuropsychol Rev 19(3):365–384
Park DC, Reuter-Lorenz P (2009) The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol 60:173–196
Park DC, Gutchess AH et al (2007) Improving cognitive function in older adults: nontraditional approaches. J Gerontol B Psychol Sci Soc Sci 62(1):152
Perneczky R, Wagenpfeil S et al (2010) Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology 75(2):137–142
Prakash RS, Voss MW et al (2011) Cardiorespiratory fitness and attentional control in the aging brain. Front Hum Neurosci 4:229
Raz N, Lindenberger U et al (2005) Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex 15(11):1676–1689
Salthouse TA (2006) Mental exercise and mental aging. Perspect Psychol Sci 1(1):68–87
Snowdon DA (2003) Healthy aging and dementia: findings from the nun study. Ann Intern Med 139(2):450–454
Steenland K, MacNeil J et al (2009) Recent trends in Alzheimer disease mortality in the United States, 1999–2004. Alzheimer Dis Assoc Disord 23(2):165–170
Willis SL, Tennstedt SL et al (2006) Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 296(23):2805–2814
Witte AV, Fobker M et al (2009) Caloric restriction improves memory in elderly humans. Proc Nat Acad Sci 106(4):1255–1260
Yaffe K, Lindquist K et al (2010) The effect of maintaining cognition on risk of disability and death. J Am Geriatr Soc 58(5):889–894
Zubenko GS, Hughes HB III et al (2007) Genome survey for loci that influence successful aging: results at 10-cM resolution. Am J Geriatr Psychiatry 15(3):184–193
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Depp, C.A., Harmell, A., Vahia, I.V. (2011). Successful Cognitive Aging. In: Pardon, MC., Bondi, M. (eds) Behavioral Neurobiology of Aging. Current Topics in Behavioral Neurosciences, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_158
Download citation
DOI: https://doi.org/10.1007/7854_2011_158
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-23874-1
Online ISBN: 978-3-642-23875-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)