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The Future of Boron in Medicinal Chemistry: Therapeutic and Diagnostic Applications

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 17))

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Abstract

Because of its unique electronic structure, boron has special properties useful in designing new diagnostic and therapeutic agents. Specifically, boron’s strong Lewis acidity and ability to undergo fission under neutron bombardment form the foundation for boron-containing compounds to be developed as inhibitors of hydrolytic enzymes, chemosensors and artificial receptors for carbohydrates and other Lewis bases, and boron neutron capture agents. A number of boron-containing compounds have been evaluated in animal and human studies for diagnostics and therapeutic applications. One compound in particular, Velcade, has been approved as an anticancer agent. This chapter highlights some of the most significant contributions in the field.

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  1. Department of Chemistry and the Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, 30303, USA

    Alexander Draganov, Danzhu Wang & Binghe Wang

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  1. Alexander Draganov
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  2. Danzhu Wang
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    Jacob Schwarz

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Draganov, A., Wang, D., Wang, B. (2014). The Future of Boron in Medicinal Chemistry: Therapeutic and Diagnostic Applications. In: Schwarz, J. (eds) Atypical Elements in Drug Design. EGC 2015. Topics in Medicinal Chemistry, vol 17. Springer, Cham. https://doi.org/10.1007/7355_2014_65

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