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β-Lactams: Unique Structures of Distinction for Novel Molecules pp 1–63Cite as

Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests

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Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 30))

Abstract

β-Lactams play a significant role in organic synthesis in addition to its importance as the core structure of β-lactam antibiotics. The “β-lactam synthon method” introduced in late 1970s has greatly advanced the use of β-lactams as key intermediates for the synthesis of biologically active compounds such as nonprotein amino acids, peptides, peptidomimetics, and complex natural products and congeners. This chapter describes the advances in the synthesis of β-lactams with excellent enantiopurity, useful patterns of β-lactam ring cleavage, ring-opening coupling, and applications of the β-lactam synthon method to the synthesis of biologically active compounds of medicinal interests. In addition, novel β-lactams, exhibiting potent activities, not as antibacterials but as anticancer and cholesterol-controlling agents, are described.

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Authors and Affiliations

  1. Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY, USA

    Iwao Ojima, Edison S. Zuniga & Joshua D. Seitz

  2. Department of Chemistry, Stony Brook University, Stony Brook, NY, USA

    Iwao Ojima, Edison S. Zuniga & Joshua D. Seitz

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  1. Iwao Ojima
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  2. Edison S. Zuniga
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  3. Joshua D. Seitz
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Correspondence to Iwao Ojima .

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  1. Dept. Chemistry, University of Texas-Pan American, W. University Drive 1201, Edinburg, 78539, Texas, USA

    Bimal K. Banik

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Ojima, I., Zuniga, E.S., Seitz, J.D. (2012). Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests. In: Banik, B. (eds) β-Lactams: Unique Structures of Distinction for Novel Molecules. Topics in Heterocyclic Chemistry, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2012_86

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