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Synthesis of β-Lactams Through Alkyne–Nitrone Cycloadditions

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β-Lactams: Unique Structures of Distinction for Novel Molecules

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 30))

Abstract

The [3+2] cycloaddition reaction between an alkyne and nitrone in the presence of copper catalyst leading to the formation of β-lactam is known as the Kinugasa reaction. Over the years, the Kinugasa reaction has been established as a robust and versatile route for the synthesis of β-lactam derivatives in both cis and trans configuration. This review has focused on various approaches highlighting recent stereoselective syntheses along with plausible mechanisms and other salient features.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Surya Sen College, Siliguri, 734004, India

    Bablee Mandal

  2. Department of Chemistry, North Bengal University, Darjeeling, 734013, India

    Basudeb Basu

Authors
  1. Bablee Mandal
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  2. Basudeb Basu
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Correspondence to Basudeb Basu .

Editor information

Editors and Affiliations

  1. Dept. Chemistry, University of Texas-Pan American, W. University Drive 1201, Edinburg, 78539, Texas, USA

    Bimal K. Banik

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Mandal, B., Basu, B. (2012). Synthesis of β-Lactams Through Alkyne–Nitrone Cycloadditions. In: Banik, B. (eds) β-Lactams: Unique Structures of Distinction for Novel Molecules. Topics in Heterocyclic Chemistry, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2012_85

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