Skip to main content
SpringerLink
Log in

Transplantation of Limbal Stem Cells

  • Chapter
Book cover Cornea and External Eye Disease

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alison MR, Poulsom R, Forbes S, Wright NA (2002) An introduction to stem cells. J Pathol 197:419–423

    PubMed  Google Scholar 

  2. Azuara-Blanco A, Pillai CT, Dua HS (1999) Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol 83:399–402

    CAS  PubMed  Google Scholar 

  3. Bishop AE, Buttery LD, Polak JM (2002) Embryonic stem cells. J Pathol 197:424–429

    Article  PubMed  Google Scholar 

  4. Buck RC (1979) Cell migration in repair of mouse corneal epithelium. Invest Ophthalmol Vis Sci 18:767–784

    CAS  PubMed  Google Scholar 

  5. Buck RC (1985) Measurement of centripetal migration of normal corneal epithelial cells in the mouse. Invest Ophthalmol Vis Sci 26:1296–1299

    CAS  PubMed  Google Scholar 

  6. Chiou AG-Y, Florakis GJ, Kazim M (1998) Management of conjunctival cicatrizing diseases and severe ocular surface dysfunction. Surv Ophthalmol 43:19–46

    CAS  PubMed  Google Scholar 

  7. Cooper D, Schermer A, Sun TT (1985) Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest 52:243–256

    CAS  PubMed  Google Scholar 

  8. Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM (1989) Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57:201–209

    Article  CAS  PubMed  Google Scholar 

  9. Davanger M, Evensen A (1971) Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 229:560–561

    Article  CAS  PubMed  Google Scholar 

  10. Daya SM, Holland EJ, Mannis M (2001) Living related conjunctival limbal allograft. In: Holland EJ, Mannis MJ (eds) Ocular surface disease, medical and surgical management, Chap 17. Springer, New York, pp 201–207

    Google Scholar 

  11. Djalilian AR, Nussenblatt RB, Holland EJ (2001) Immunosuppressive therapy in ocular surface transplantation. In: Holland EJ, Mannis MJ (eds) Ocular surface disease, medical and surgical management, Chap 22. Springer, New York, pp 243–252

    Google Scholar 

  12. Dong Y, Roos M, Gruijters T, Donaldson P, Bullivant S, Beyer E (1994) Differential expression of two gap junction proteins in corneal epithelium. Eur J Cell Biol 64:95–100

    CAS  PubMed  Google Scholar 

  13. Dua HS (1995) Stem cells of the ocular surface: Scientific principles and clinical applications. Br J Ophthalmol 79:968–969

    CAS  PubMed  Google Scholar 

  14. Dua HS (1998) The conjunctiva in corneal epithelial wound healing. Br J Ophthalmol 82:1407–1411

    CAS  PubMed  Google Scholar 

  15. Dua HS (2001) Sequential sector conjunctival epitheliectomy. In: Holland EJ, Mannis MJ (eds) Ocular surface disease, medical and surgical management, Chap 14. Springer, New York, pp 168–174

    Google Scholar 

  16. Dua HS, Azuara-Blanco A (1999) Allo-limbal transplantation in patients with limbal stem-cell deficiency. Br J Ophthalmol 83:414–419

    CAS  PubMed  Google Scholar 

  17. Dua HS, Azuara-Blanco A (1999) Amniotic membrane transplantation. Br J Ophthalmol 83:748–752

    CAS  PubMed  Google Scholar 

  18. Dua HS, Azuara-Blanco A (2000) Limbal stem cells of the corneal epithelium. Surv Ophthalmol 44:415–425

    CAS  PubMed  Google Scholar 

  19. Dua HS, Azuara-Blanco A (2000) Autologous limbal transplantation in unilateral stem cell deficiency. Br J Ophthalmol 84:273–278

    CAS  PubMed  Google Scholar 

  20. Dua HS, Forrester JV (1987) Clinical patterns of corneal epithelial wound healing. Am J Ophthalmol 104:481–489

    CAS  PubMed  Google Scholar 

  21. Dua HS, Forrester JV (1990) The corneoscleral limbus in human corneal epithelial wound healing. Am J Ophthalmol 110:646–656

    CAS  PubMed  Google Scholar 

  22. Dua HS, Gomes JA, Singh A (1994) Corneal epithelial wound healing. Br J Ophthalmol 78:401–408

    CAS  PubMed  Google Scholar 

  23. Dua HS, Gomes JAP, Jindal V, Appa SN, Schwarting R, Eagle RC Jr, Donoso LA, Laibson PR (1994) Mucosa specific lymphocytes in the human conjunctiva, corneoscleral limbus and lacrimal gland. Curr Eye Res 13:87–93

    CAS  PubMed  Google Scholar 

  24. Dua HS, Saini JS, Azuara-Blanco A, Gupta P (2000) Limbal stem cell deficiency: Concept, aetiology, clinical presentation, diagnosis and management. Ind J Ophthalmol 48:83–92

    CAS  Google Scholar 

  25. Dua HS, Joseph A, Shanmuganathan VA, Jones RE (2003) Stem cell differentiation and effects of deficiency. Eye 17:877–885

    Article  CAS  PubMed  Google Scholar 

  26. Dua HS, Gomes JAP, King AJ, Maharajan S (2004) The amniotic membrane in ophthalmology. Surv Ophthalmol 49:51–77

    PubMed  Google Scholar 

  27. Dua HS, Shanmuganathan VA, Powell-Richards AO, Tighe PJ, Joseph A (2005) Limbal epithelial crypts — A novel anatomical structure and a putative limbal stem cell niche. Br J Ophthalmol (in press)

    Google Scholar 

  28. Ebato B, Friend J, Thoft RA (1987) Comparison of central and peripheral human corneal epithelium in tissue culture. Invest Ophthalmol Vis Sci 28:1450–1456

    CAS  PubMed  Google Scholar 

  29. Ebato B, Friend J, Thoft RA (1988) Comparison of limbal and peripheral human corneal epithelium in tissue culture. Invest Ophthalmol Vis Sci 29:1533–1537

    CAS  PubMed  Google Scholar 

  30. Eggli P, Boulton M, Marshall J (1989) Growth characteristics of central and peripheral bovine corneal epithelial cells in vitro. Graefes Arch Clin Exp Ophthalmol 227:263–270

    Article  CAS  PubMed  Google Scholar 

  31. Friedenwald JSB, Buschke W (1944) Some factors concerned in the mitotic and wound-healing activities of the corneal epithelium. Trans Am Ophthalmol Soc 42:371–383

    CAS  Google Scholar 

  32. Fuchs E, Segre JA (2000) Stem cells: a new lease on life. Cell 100:143–155

    Article  CAS  PubMed  Google Scholar 

  33. Fujishima H, Shimazaki J, Tsubota K (1996) Temporary corneal stem cell dysfunction after radiation therapy. Br J Ophthalmol 80:911–914

    CAS  PubMed  Google Scholar 

  34. Gipson IK, Grill SM, Spurr SJ, Brennan SJ (1983) Hemidesmosome formation in vitro. J Cell Biol 97:849–857

    Article  CAS  PubMed  Google Scholar 

  35. Gipson IK, Kiorpes TC (1982) Epithelial sheet movement: protein and glycoprotein synthesis. Dev Biol 92:259–262

    Article  CAS  PubMed  Google Scholar 

  36. Goodell MA, Rosenzweig M, Kim H, Marks DF, De Maria M, Paradis G, Grupp SA, Ssieff CA, Mulligan RC, Johnson RP (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183:1797–806

    Article  CAS  PubMed  Google Scholar 

  37. Hanna C, O’Brien JE (1960) Cell production and migration in the epithelial layer of the cornea. Arch Ophthalmol 64:536–539

    CAS  PubMed  Google Scholar 

  38. Henderson TR, Coster DJ, Williams KA (2001) The long term outcome of limbal allografts: the search for surviving cells. Br J Ophthalmol 85:604–609

    Article  CAS  PubMed  Google Scholar 

  39. Henderson TR, Findlay I, Matthews PL, Noble BA (2001) Identifying the origin of single corneal cells by DNA fingerprinting: part I — application to limbal allografting. Cornea 20:400–403

    CAS  PubMed  Google Scholar 

  40. Henderson TR, Findlay I, Matthews PL, Noble BA (2001) Identifying the origin of single corneal cells by DNA fingerprinting: part II — application to limbal allografting. Cornea 20:404–407

    CAS  PubMed  Google Scholar 

  41. Holland EJ (1996) Epithelial transplantation for the management of severe ocular surface disease. Trans Am Ophthalmol Soc 94:677–743

    CAS  PubMed  Google Scholar 

  42. Holland EJ, Schwartz GS (1996) The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea 15:549–556

    CAS  PubMed  Google Scholar 

  43. Huang AJ, Tseng SC (1991) Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci 32:96–105

    CAS  PubMed  Google Scholar 

  44. Janes SM, Lowell S, Hutter C (2002) Epidermal stem cells. J Pathol 197:479–491

    Article  PubMed  Google Scholar 

  45. Jones PH, Watt FM (1993) Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73:713–724

    Article  CAS  PubMed  Google Scholar 

  46. Joseph A, Powell Richards AOR, Shanmuganathan VA, Dua HS (2004) Epithelial cell characteristics of cultured human limbal explants. Br J Ophthalmol 88:393–398

    Article  CAS  PubMed  Google Scholar 

  47. Joseph A, Hossain P, Jham S, Jones RE, Tighe P, McIntosh RS, Dua HS (2003) Expression of CD34 and L-selectin on human corneal keratocytes. Invest Ophthalmol Vis Sci 44:4689–4692

    Article  PubMed  Google Scholar 

  48. Kenyon KR, Rapoza PA (1995) Limbal allograft transplantation for ocular surface disorders. Ophthalmology 102(Suppl):101–102

    Google Scholar 

  49. Kenyon KR, Tseng SC (1989) Limbal autograft transplantation for ocular surface disorders. Ophthalmology 96:709–22; discussion 722–723

    CAS  PubMed  Google Scholar 

  50. Kim JC, Tseng SCG (1995) Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 15:473–484

    Google Scholar 

  51. Kinoshita S, Friend J, Thoft RA (1981) Sex chromatin of donor corneal epithelium in rabbits. Invest Ophthalmol Vis Sci 21:434–441

    CAS  PubMed  Google Scholar 

  52. Lagnado R, King AJ, Donald F, Dua HS (2003) A protocol for low contamination risk of autologous serum drops in the management of ocular surface disorders. Br J Ophthalmol 88:464–465

    Google Scholar 

  53. Lauweryns B, van den Oord JJ, Volpes R, Foets B, Missotten (1991) Distribution of very late activation integrins in the human cornea. An immunohistochemical study using monoclonal antibodies. Invest Ophthalmol Vis Sci 32:2079–2085

    CAS  PubMed  Google Scholar 

  54. Lauweryns B, van den Oord JJ, Missotten L (1993) The transitional zone between limbus and peripheral cornea. An immunohistochemical study. Invest Ophthalmol Vis Sci 34:1991–1999

    CAS  PubMed  Google Scholar 

  55. Lauweryns B, van den Oord JJ, De Vos R, Missotten L (1993) A new epithelial cell type in the human cornea. Invest Ophthalmol Vis Sci 34:1983–1990

    CAS  PubMed  Google Scholar 

  56. Lavker RM, Dong G, Cheng SZ, Kudoh K, Cotsarelis G, Sun TT (1991) Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes. Invest Ophthalmol Vis Sci 32:1864–1875

    CAS  PubMed  Google Scholar 

  57. Leblond CP (1981) The life history of cells in renewing systems. Am J Anat 160:114–158

    Article  CAS  PubMed  Google Scholar 

  58. Matic M, Petrov IN, Chen S, Wang C, Dimitrijevich SD, Wolosin JM (1997) Stem cells of the corneal epithelium lack connexins and metabolite transfer capacity. Differentiation 61:251–260

    Article  CAS  PubMed  Google Scholar 

  59. Matsuda M, Ubels JL, Edelhauser HF (1985) A larger corneal epithelial wound closes at a faster rate. Invest Ophthalmol Vis Sci 26:897–900

    CAS  PubMed  Google Scholar 

  60. Mills JC, Gordon JI (2001) The intestinal stem cell niche: there grows the neighborhood. Proc Natl Acad Sci USA 98:12334–12336

    CAS  PubMed  Google Scholar 

  61. Morrison SJ, Shah NM, Anderson DJ (1997) Regulatory mechanisms in stem cell biology. Cell 88:287–298

    Article  CAS  PubMed  Google Scholar 

  62. Pellegrini G, Traverso CE, Franzi AT (1997) Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 349:990–993

    Article  CAS  PubMed  Google Scholar 

  63. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S (2001) p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98:3156–3161

    Article  CAS  PubMed  Google Scholar 

  64. Pfister RR (1994) Corneal stem cell disease: concepts, categorization, and treatment by auto-and homotransplantation of limbal stem cells. CLAO J 20:64–72

    CAS  PubMed  Google Scholar 

  65. Potten SC, Loeffler M (1987) Epidermal cell proliferation. I. Changes with time in the proportion of isolated, paired and clustered labeled cells in sheets of murine epidermis. Virchows Arch 53: 286–300

    Google Scholar 

  66. Potten SC, Loeffler M (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lesson for and from the crypt. Development 110: 1001–1020

    CAS  PubMed  Google Scholar 

  67. Potten CS, Morris RJ (1988) Epithelial stem cells in vivo. J Cell Sci 10(Suppl):45–62

    CAS  Google Scholar 

  68. Poulsom R, Alison MR, Forbes SJ, Wright NA (2002) Adult stem cell plasticity. J Pathol 197: 441–456

    Article  PubMed  Google Scholar 

  69. Puangsricharern V, Tseng SC (1995) Cytologic evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology 102:1476–1485

    CAS  PubMed  Google Scholar 

  70. Rao SK, Rajgopal R, Sitalakshmi G, Padmanabhan P (1999) Limbal allografting from related live donors for corneal surface reconstruction. Ophthalmology 106:822–828

    CAS  PubMed  Google Scholar 

  71. Reinhard T, Spelsberg H, Henke L, Kontopoulos T, Enczmann J, Wernet P, Berschick P, Sundmacher R, Bohringer D (2004) Long-term results of allogeneic penetrating limbo-keratoplasty in total limbal stem cell deficiency. Ophthalmology 111: 775–782

    Article  PubMed  Google Scholar 

  72. Reis A, Reinhard T, Voiculescu A et al. (1999) Mycophenolate mofetil versus cyclosporin A in high risk penetrating keratoplasty. Br J Ophthalmol 83:1268–1271

    CAS  PubMed  Google Scholar 

  73. Schermer A, Galvin S, Sun TT (1986) Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol 103:49–62

    Article  CAS  PubMed  Google Scholar 

  74. Schwab IR (1999) Cultured corneal epithelia for ocular surface disease. Trans Am Ophthalmol Soc 97:891–986

    CAS  PubMed  Google Scholar 

  75. Schwab IR, Reyes M, Isseroff RR (2000) Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 19:421–426

    CAS  PubMed  Google Scholar 

  76. Shimazaki J, Kaido M, Shinozaki N, Shimmura S, Munkhbat B, Hagihara M, Tsuji K, Tsubota K (1999) Evidence of long term survival of donor derived cells after limbal allograft transplantation. Invest Ophthalmol Vis Sci 40:1664–1668

    CAS  PubMed  Google Scholar 

  77. Shimazaki J, Aiba M, Goto E, Kato N, Shimmura S, Tsubota K (2002) Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders. Ophthalmology 109:1285–90

    Article  PubMed  Google Scholar 

  78. Sloper ML, Powell RJ, Dua HS (2001) Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts. Ophthalmology 108:1838–1844

    Article  CAS  PubMed  Google Scholar 

  79. Spradling A, Drummond-Barbosas D, Kai T (2001) Stem cells find their niche. Nature 414:98–104

    Article  CAS  PubMed  Google Scholar 

  80. Srinivasan BD, Eakins KE (1979) The reepithelialization of rabbit cornea following single and multiple denudation. Exp Eye Res 29:595–600

    Article  CAS  PubMed  Google Scholar 

  81. Sundmacher R, Reinhard T (1996) Central corneolimbal transplantation under systemic cyclosporin A cover for severe limbal stem cell insufficiency. Graefes Arch Clin Exp Ophthalmol 234(Suppl):122–125

    Google Scholar 

  82. Sundmacher R, Reinhard T (1998) Homologous lamellar central limbokeratoplasty in severe limbal stem cell deficiency. Klin Monatsbl Augenheilkd 213:254–255

    CAS  PubMed  Google Scholar 

  83. Tan DTH, Ficker LA, Buckley RJ (1996) Limbal transplantation. Ophthalmology 103:29–36

    CAS  PubMed  Google Scholar 

  84. Thoft RA, Friend J (1983) The X,Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 24:1442–1443

    CAS  PubMed  Google Scholar 

  85. Thoft RA, Wiley LA, Sundarraj N (1989) The multipotential cells of the limbus. Eye 3:109–113

    PubMed  Google Scholar 

  86. Townsend WM (1991) The limbal palisades of Vogt. Trans Am Ophthalmol Soc 89:721–756

    CAS  PubMed  Google Scholar 

  87. Tsai RJ, Li LM, Chen JK (2000) Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Eng J Med 3431: 86–93

    Google Scholar 

  88. Tseng SC (1989) Concept and application of limbal stem cells. Eye 3:141–157

    PubMed  Google Scholar 

  89. Tseng SCG, Tsubota K (1997) Important concepts for treating ocular surface and tear disorders. Am J Ophthalmol 124:825–835

    CAS  PubMed  Google Scholar 

  90. Tseng SCG, Prabhasawat P, Barton K, Gray T, Meller D (1998) Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol 116:431–441

    CAS  PubMed  Google Scholar 

  91. Tsubota K, Toda I, Saito H, Shinozaki N, Shimazaki J (1995) Reconstruction of the corneal epithelium by limbal allograft transplantation for severe ocular surface disorders. Ophthalmology 102: 1486–1496

    CAS  PubMed  Google Scholar 

  92. Tsubota K, Satake Y, Ohyama M, Toda I, Takano Y, Ono M, Shinozaki N, Shimazaki J (1996) Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol 122:38–52

    CAS  PubMed  Google Scholar 

  93. Tsubota K, Satake Y, Shimazaki J (1996) Treatment of severe dry eye. Lancet 348:123

    Article  CAS  PubMed  Google Scholar 

  94. Watanabe K, Nishida K, Yamato M, Umemato T, Sumide T, Yamamoto K, Maeda N, Watanabe H, Okano T, Tano Y (2004) Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2. FEBS Lett 565:6–10

    Article  CAS  PubMed  Google Scholar 

  95. Watt FM, Hogan BLM (2000) Out of Eden: stem cells and their niches. Science 287:1427–1430

    Article  CAS  PubMed  Google Scholar 

  96. Wolosin JM, Xiong X, Schutte M, Stegman Z, Tieng A (2000) Stem cells and differentiation stages in the limbo-corneal epithelium. Prog Retin Eye Res 19:223–255

    Article  CAS  PubMed  Google Scholar 

  97. Xu KP, Wu Y, Zhou J, Zhang X (1999) Survival of limbal stem cell allografts after administration of cyclosporin A. Cornea 18:159–165

    Google Scholar 

  98. Zhao X, Das AV, Thoreson WB, James J, Wattnem TE, Rodriguez-Sierra J (2002) Adult corneal limbal epithelium: a model for studying neural potential of non-neural stem cells/progenitors. Dev Biol 250:317–331

    Article  CAS  PubMed  Google Scholar 

  99. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7:1028–1034

    Article  CAS  PubMed  Google Scholar 

  100. Zieske JD (1994) Perpetuation of stem cells in the eye. Eye 8:163–169

    PubMed  Google Scholar 

  101. Zieske JD, Bukusoglu G, Yankauckas MA (1992) Characterization of a potential marker of corneal epithelial stem cells. Invest Ophthalmol Vis Sci 33:143–152

    CAS  PubMed  Google Scholar 

  102. Zieske JD, Bukusoglu G, Yankauckas MA, Wasson ME, Keutmann HT (1992) Alpha-enolase is restricted to basal cells of stratified squamous epithelium. Dev Biol 151:18–26

    Article  CAS  PubMed  Google Scholar 

  103. Zieske JD, Wasson M (1993) Regional variation in distribution of EGF receptor in developing and adult corneal epithelium. J Cell Sci 106:145–152

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eye ENT Centre, Queens Medical Centre, University of Nottingham, Derby Road, Nottingham, NG7 2UH, UK

    Harminder S. Dua MD, PhD (Chair)

Authors
  1. Harminder S. Dua MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University Eye Hospital, Killianstrasse 5, 79106, Freiburg, Germany

    Thomas Reinhard MD (Professor of Ophthalmology) (Professor of Ophthalmology)

  2. Cornea & External Diseases Service, Moorfields Eye Hospital, London, EC1V 2PD, UK

    D.F.P. Larkin MD, MRCPF, FRCS

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dua, H.S. (2006). Transplantation of Limbal Stem Cells. In: Reinhard, T., Larkin, D. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31226-9_3

Download citation

  • DOI: https://doi.org/10.1007/3-540-31226-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22600-0

  • Online ISBN: 978-3-540-31226-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation