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DNA Methylation: Development, Genetic Disease and Cancer pp 179–198Cite as

Genome-wide Analysis of DNA Methylation Changes in Human Malignancies

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 310))

Abstract

DNA methylation is an epigenetic modification of the DNA sequence and thus does not change the genetic code but affects chromosomal stability and gene expression. DNA methylation patterns are heritable and can be passed on to the daughter cell. In this review, we briefly summarize our current knowledge on normal DNA methylation patterns and move on to discuss the current state of the field with respect to altered DNA methylation in cancer. We make a special attempt to address current questions relating to genome-wide DNA methylation patterns. Since DNA methylation is used as a therapeutic target in clinical studies, it is of utmost importance to define potential target sequences that could be used as diagnostic or prognostic markers. We conclude the review by outlining possible scenarios that may explain tumor type-specific DNA methylation patterns described by assays evaluating genome-wide levels of DNA methylation.

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Authors and Affiliations

  1. Division of Human Cancer Genetics, The Ohio State University, Tzagournis Medical Research Facility 464A, 420 West 12th Ave., Columbus, OH, 43210, USA

    C. Plass

  2. Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    D. J. Smiraglia

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  1. C. Plass
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Correspondence to C. Plass .

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  1. Institut für Genetik, Universität zu Köln, Zülpicher Str. 47, 50674, Köln, Germany

    Walter Doerfler  & Petra Böhm  & 

  2. Institut für Klinische und Molekulare Virologie, Universität Erlangen, Schlossgarten 4, 91054, Erlangen, Germany

    Walter Doerfler

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Plass, C., Smiraglia, D.J. (2006). Genome-wide Analysis of DNA Methylation Changes in Human Malignancies. In: Doerfler, W., Böhm, P. (eds) DNA Methylation: Development, Genetic Disease and Cancer. Current Topics in Microbiology and Immunology, vol 310. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-31181-5_9

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