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Molecular Chaperones and Cancer Immunotherapy

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Molecular Chaperones in Health and Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 172))

Abstract

As one of the most abundant and evolutionally conserved intracellular proteins, heat shock proteins, also known as stress proteins or molecular chaperones, perform critical functions in maintaining cell homeostasis under physiological as well as stress conditions. Certain chaperones in extracellular milieu are also capable of modulating innate and adaptive immunity due to their ability to chaperone polypeptides and to interact with the host’s immune system, particularly professional antigen-presenting cells. The immunomodulating properties of chaperones have been exploited for cancer immunotherapy. Clinical trials using chaperone-based vaccines to treat various malignancies are ongoing.

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Authors and Affiliations

  1. Department of Cellular Stress Biology and Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    X.-Y. Wang & J.R. Subjeck

  2. Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    J.G. Facciponte

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  1. X.-Y. Wang
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  2. J.G. Facciponte
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  3. J.R. Subjeck
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Correspondence to X.-Y. Wang .

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Editors and Affiliations

  1. Freiburg i.

    K. Starke

  2. Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Matthias Gaestel (Professor) (Professor)

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Wang, XY., Facciponte, J., Subjeck, J. (2006). Molecular Chaperones and Cancer Immunotherapy. In: Starke, K., Gaestel, M. (eds) Molecular Chaperones in Health and Disease. Handbook of Experimental Pharmacology, vol 172. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29717-0_13

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