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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential pp 25–42Cite as

The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 293))

Abstract

CD25+ CD4+ T cells (TR) are a naturally arising subset of regulatory T cells important for the preservation of self-tolerance and the prevention of autoimmunity. Although there is substantial data that TCR specificity is important for TR development and function, relatively little is known about the antigen specificity of naturally arising TR. Here, we will review the available evidence regarding naturally arising TR TCR specificity in the context of TR development, function, and homeostasis.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 98195, USA

    C.-S. Hsieh

  2. Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Seattle, WA, 98195, USA

    A. Y. Rudensky

Authors
  1. C.-S. Hsieh
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  2. A. Y. Rudensky
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Editor information

Editors and Affiliations

  1. Atlanta, Georgia

    R.W. Compans

  2. Birmingham, Alabama

    M.D. Cooper

  3. Kyoto

    T. Honjo

  4. Philadelphia, Pennsylvania

    H. Koprowski

  5. Basel

    F. Melchers

  6. La Jolla, California

    M.B.A. Oldstone  & P.K. Vogt  & 

  7. Oslo

    S. Olsnes

  8. Bethesda, Maryland

    M. Potter

  9. Munich

    H. Wagner

  10. Abteilung Entwicklungsimmunologie, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Bruno Kyewski

  11. Abteilung Immungenetik, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Elisabeth Suri-Payer

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© 2005 Springer-Verlag Berlin Heidelberg

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Hsieh, CS., Rudensky, A.Y. (2005). The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology. In: Compans, R., et al. CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential. Current Topics in Microbiology and Immunology, vol 293. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27702-1_2

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