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Functional Effects and Molecular Mechanisms of Subtype-Selective ERα and ERβ Agonists in the Cardiovascular System

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Tissue-Specific Estrogen Action

Part of the book series: Ernst Schering Foundation Symposium Proceedings ((SCHERING FOUND,volume 2006/1))

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Abstract

Gender differences in the development of cardiovascular disease suggested for a protective function of estrogens in heart disease. The negative or neutral outcome of clinical trials on hormone replacement therapy provides clear evidence that the role of female sex hormones in the cardiovascular system is more complex than previously thought. In particular, the function of estrogens can not be understood without detailed knowledge on the specific function of both estrogen receptor subtypes in the heart and in the vasculature. In here, we review recent studies on subtype selective ERα and ERβ agonists in different animal models of hypertension, cardiac hypertrophy and vascular inflammation. The results indicate that the activation of specific ER subtypes confers specific as well as redundant protective effects in hypertensive heart disease that might ultimately translate into novel treatment options for hypertensive heart disease.

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Authors and Affiliations

  1. Medizinische Klinik I, University of Würzburg, Josef-Schneider Str. 2, 97080, Würzburg, Germany

    P. A. Arias-Loza, V. Jazbutyte, G. Ertl & T. Pelzer

  2. Gynecology and Andrology, Schering AG, Berlin, Müllerstr. 178, 13342, Berlin, Germany

    K.-H. Fritzemeier & C. Hegele-Hartung

  3. Division of Cardiology, Manchester Royal Infirmary, University of Manchester, Oxford Road, M13 9WL, Manchester, UK

    L. Neyses

Authors
  1. P. A. Arias-Loza
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  2. V. Jazbutyte
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  3. K.-H. Fritzemeier
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  4. C. Hegele-Hartung
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  5. L. Neyses
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  6. G. Ertl
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  7. T. Pelzer
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Correspondence to T. Pelzer .

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K. S. Korach T. Wintermantel

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© 2007 Springer-Verlag

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Arias-Loza, P.A. et al. (2007). Functional Effects and Molecular Mechanisms of Subtype-Selective ERα and ERβ Agonists in the Cardiovascular System. In: Korach, K.S., Wintermantel, T. (eds) Tissue-Specific Estrogen Action. Ernst Schering Foundation Symposium Proceedings, vol 2006/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/2789_2006_018

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  • DOI: https://doi.org/10.1007/2789_2006_018

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  • Online ISBN: 978-3-540-49548-2

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