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Stereotactic Body Radiation Therapy pp 91–114Cite as

Treatment Planning for Stereotactic Body Radiation Therapy

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Stereotactic body radiation therapy (SBRT) is a novel cancer treatment strategy where ultra-high doses per fraction are used, generally in the range of 8–20 Gy per fraction in a hypofractionated regimen of five or fewer fractions, to achieve a high biologically effective dose (BED). Such high doses per treatment were unimaginable in the past because of concerns about radiation-induced injury to organs at risk (OARs) if large volumes of OARs were irradiated to high doses. However, with recent technical advancements in highly conformal treatment planning, image-guided radiotherapy, and delivery technologies, it has become possible to safely deliver very large fractional doses of radiation to lesions in the lung, liver, spine, pancreas, and other disease sites. SBRT involves technically sophisticated treatment planning processes consisting of a chain of activities including: immobilization/simulation, motion management, imaging for treatment planning, segmentation, beam-setup and optimization, and plan verification. Clinicians are usually concerned of a possible compromise in treatment efficacy for any weak link in the planning chain process. A further cause for concern is the influence that errors or inaccuracies in the dose calculation may have on the treatment efficacy. Such errors arise from inherent limitations in the calculation algorithm used, which are more significant in some anatomical sites than others. In this chapter, treatment planning for linac-based delivery systems for lung, liver, spine, and pancreas is reviewed. In addition, the impact of the choice of calculation algorithm on the accuracy of dose distributions is discussed.

Author's Contribution M. Miften, S.K. Das, I. Chetty, D. Westerly made substantial contributions to the conception, design, drafting, and writing of this book chapter. This book chapter has been seen, read, and agreed upon in its content by all the designated authors.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Colorado School of Medicine, MS F706 1665 Aurora Court, Ste 1032, Aurora, CO, 80045, USA

    Moyed Miften & David Westerly

  2. Department of Radiation Oncology, Duke University, Durham, NC, USA

    Shiva K. Das

  3. Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA

    Indrin J. Chetty

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  1. Moyed Miften
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  2. Shiva K. Das
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  3. Indrin J. Chetty
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  4. David Westerly
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Correspondence to Moyed Miften .

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Editors and Affiliations

  1. , Department of Radiation Oncology, Case Western Reserve University, Euclid Avenue 11100, Cleveland, 44106, Ohio, USA

    Simon S. Lo

  2. , Department of Radiation Oncology, Weil Cornell Medical College, Fannin, Ste#DB1-077 6565, Houston, 77030, Texas, USA

    Bin S. Teh

  3. Cancer Institute, Department of Radiation Oncology, National University Hospital, Lower Kent Ridge Road 5, Singapore, 119074, Singapore

    Jiade J. Lu

  4. , Department of Radiation Oncology, University of Colorado, Aurora, 80045, Colorado, USA

    Tracey E. Schefter

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Miften, M., Das, S.K., Chetty, I.J., Westerly, D. (2012). Treatment Planning for Stereotactic Body Radiation Therapy. In: Lo, S., Teh, B., Lu, J., Schefter, T. (eds) Stereotactic Body Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_615

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  • DOI: https://doi.org/10.1007/174_2012_615

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