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Lung Cancer

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Re-irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Local/regional recurrence with or without distant metastases is a common pattern of failure after first-line treatment for lung cancer. It is virtually unknown which proportion of patients initially treated with chest radiotherapy undergo reirradiation during the natural course of the disease. The majority of available studies are retrospective in nature and of limited size. External beam radiation therapy has been used to treat local/regional intrathoracic recurrences after previous radiation therapy for lung cancer, mostly non-small cell histology. In most cases the aim of treatment was palliation of symptoms. However, the increasing availability of new technology such as intensity-modulated and stereotactic radiotherapy has resulted in preliminary data on more aggressive regimens. Endobronchial brachytherapy remains one of the cornerstones of successful palliative approaches in patients with symptomatic endobronchial recurrences of lung cancer. While no established guidelines are available, due to considerable variety in first-line radiation therapy parameters, different planning and retreatment characteristics (including different reirradiation technology used), and lack of validated prognostic factors, current wisdom calls for prudent use of available technology, with clear objectives set upfront.

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Authors and Affiliations

  1. Institute of Pulmonary Diseases, Sremska Kamenica, Serbia

    Branislav Jeremić & Zeljko Dobric

  2. Radiation Oncology Department, University Clinic, Barcelona, Spain

    Francesc Casas

  3. Institute of Oncology, Skopje, Macedonia

    Igor Stojkovski

  4. University Hospital, Kragujevac, Serbia

    Slobodan Milisavljevic

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  1. Branislav Jeremić
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  2. Francesc Casas
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  3. Igor Stojkovski
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  4. Slobodan Milisavljevic
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  5. Zeljko Dobric
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Correspondence to Branislav Jeremić .

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  1. , Dept. Internal Medicine, Nordlandssykehuset HF, Prinsensgate 164, Bodoe, 8092, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9700 RB, Netherlands

    Johannes A. Langendijk

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Jeremić, B., Casas, F., Stojkovski, I., Milisavljevic, S., Dobric, Z. (2010). Lung Cancer. In: Nieder, C., Langendijk, J. (eds) Re-irradiation: New Frontiers. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_64

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