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Biofunctionalization of Polymers and their Applications pp 181–205Cite as

Biomimetic Materials for Medical Application Through Enzymatic Modification

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Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 125))

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Abbreviations

bFGF:

Basic fibroblast growth factors

BMMP:

Biomimetic materials processing

DOPA:

3,4-Dihydroxyphenylalanine

ECM:

Extracellular matrix

Edeoxy :

Deoxytyrosinase

EGF:

Epidermal growth factor

Emet :

Metyrosinase

Eoxy :

Oxytyrosinase

ESP:

Enzyme-sensitive peptides

FN:

Fibronectin

K4:

Kringle4 domain

KDP:

Lysine donor peptide

LN:

Laminin

MMPs:

Metalloproteinases

mTGase:

Microbial transglutaminase

PDMS:

Poly(dimethylsiloxane)

PEG:

Polyethylene glycol

PTH:

Parathyroid hormone

QAP:

Glutamine acceptor peptide

TGase:

Transglutaminase

TYRase:

Tyrosinase

VEGF:

Vascular endothelial growth factor

VN:

Vitronectin

References

  1. Aberg CH, Chen TH, Olumide A, Raghavan SR, Payne GF (2004) Enzymatic grafting of peptides from case in hydrolysate to chitosan. Potential for value-added byproducts from food-processing wastes. J Agric Food Chem 51:788–793

    Google Scholar 

  2. Aeschlimann D, Mosher D, Paulsonn M (1996) Tissue transglutaminase and Factor XIIIa in cartilage and bone remodelling. Semin Thromb Haemost 22:437–444

    CAS  Google Scholar 

  3. Ando H, Adachi M, Umeda K, Matsuura A, Nonaka M, Uchio R, Tanaka H, Motoki M (1989) Purification and characteristics of a novel transglutaminase derived from microorganism. Agric Biol Chem 53:2613–2617

    CAS  Google Scholar 

  4. Aota S, Nomizu M, Yamada KM (1994) The short amino acid sequence Pro–His–Ser–Arg–Asn in human fibronectin enhances cell-adhesive function. J Biol Chem 269:24756–24761

    CAS  Google Scholar 

  5. Arrighi I, Mark S, Alvisi M, Von Rechenberg B, Hubbel JA, Schense JC (2009) Bone healing induced by local delivery of an engineered parathyroid hormone prodrug. Biomaterials 30:1763–1771

    CAS  Google Scholar 

  6. Babensee JE, McIntire LV, Mikos AG (2000) Growth factor delivery for tissue engineering. Pharm Res 17:497–504

    CAS  Google Scholar 

  7. Barber TA, Golledge SL, Castner DG, Healy KE (2003) Peptide-modified p(AAm-co-EG/AAc)IPNs grafted to bulk titanium modulate osteoblast behavior in vitro. J Biomed Mater Res A 64:38–47

    Google Scholar 

  8. Barbetta A, Massimi M, Dervigilis LC, Dentini M (2006) Enzymatic crosslinking versus radical polymerization in the preparation of gelatin-polyHIPEs and their performance as scaffolds in the culture of hepatocytes. Biomacromolecules 7:3059–3068

    CAS  Google Scholar 

  9. Biran R, Webb K, Noble MD, Tresco PA (2001) Surfactant-immobilized fibronectin enhances bioactivity and regulates sensory neurite outgrowth. J Biomed Mater Res 55:1–12

    CAS  Google Scholar 

  10. Bowness JM, Tarr AH, Wong T (1998) Increased transglutaminase activity during skin wound healing in rats. Biochim Biophys Acta 967:234–240

    Google Scholar 

  11. Broderick EP, O’Halloran DO, Rochev YA, Griffin M, Collighan RJ, Pandit AS (2005) Enzymatic stabilization of gelatin-based scaffolds. J Biomed Mater Res B Appl Biomater 72:37–42

    Google Scholar 

  12. Burke SA, Ritter-Jones M, Lee BP, Messersmith PB (2007) Thermal gelation and tissue adhesion of biomimetic hydrogels. Biomed Mater 2(4):203–210

    Google Scholar 

  13. Burton S (1994) Biocatalysis with polyphenoloxidase: a review. Catal Today 22:459–487

    CAS  Google Scholar 

  14. Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi-Agro A, Melino G (2001) Transglutaminase 5 cross-links loricrin, involucrin and small proline-rich proteins in vitro. J Biol Chem 276:35014–35023

    CAS  Google Scholar 

  15. Chau DYS, Collighan R, Verderio E, Addy V, Griffin M (2005) The cellular response to transglutaminase crosslinked collagen. Biomaterials 26:6518–6529

    CAS  Google Scholar 

  16. Chen T, Embree HD, Wu LQ, Payne GF (2002) In vitro protein–polysaccharide conjugation: tyrosinase catalyzed conjugation of gelatin and chitosan. Biopolymers 64:292–302

    CAS  Google Scholar 

  17. Chen T, Embree HE, Brown EM, Taylor MM, Payne G (2003) Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications. Biomaterials 24:2831–2841

    CAS  Google Scholar 

  18. Chen T, Janjua R, McDermott MK, Bernstein SL, Steidl SM, Payne GF (2006) Gelatin-based biomimetic tissue adhesive. Potential for retinal reattachment. J Biomed Mater Res B Appl Biomater 77:416–422

    Google Scholar 

  19. Chen TH, Small DA, McDermott MK, Bentley WE, Payne GF (2003) Enzymatic methods for in situ cell entrapment and cell release. Biomacromolecules 4:1558–1563

    CAS  Google Scholar 

  20. Chen TH, Vazquez-Duhalt R, Wu CF, Bentley WE, Payne GF (2001) Combinatorial screening for enzyme-mediated coupling. Tyrosinase-catalyzed coupling to create protein–chitosan conjugates. Biomacromolecules 2(2):456–462

    CAS  Google Scholar 

  21. Chiono V, Ciardelli V, Vozzi G, Cortez J, Barbani N, Gentile G, Giusti P (2008) Enzymatically-modified melt-extruded guides for peripheral nerve repair. Eng Life Sci 8(3):226–237

    CAS  Google Scholar 

  22. Chung SI (1972) Comparative studies on tissue transglutaminase and Factor XIIIa. Ann N Y Acad Sci 202:240–255

    Google Scholar 

  23. Ciardelli G, Gentile P, Chiono V, Mattioli-Belmonte M, Vozzi G, Barbani N, Giusti P (2010) Enzymatically crosslinked porous composite matrices for bone tissue regeneration. J Biomed Mater Res A 92:137–151

    Google Scholar 

  24. Ciardelli G, Gentile P, Mandrile R, Chiono V, Barbani N, Mattioli-Belmonte M, Vozzi G, Giusti P (2007) Biomimetic materials for tissue engineering through enzyme mediated protein modification. In: Proceedings of EPF European polymer congress, 2–6 July, Portoroz, Slovenia, p 140

    Google Scholar 

  25. Damodaran G, Collighan R, Griffin M, Navsaria H, Pandit A (2009) Tailored laminin-332 α3 sequence is tethered through an enzymatic linker to a collagen scaffold to promote cellular adhesion. Acta Biomater 5:2441–2450

    CAS  Google Scholar 

  26. De Jong GAH, Koppelman SJ (2002) Transglutaminase catalyzed reactions: impact on food applications. J Food Sci 67:2798–2806

    Google Scholar 

  27. Deacon MP, Davis SS, Waite JH, Harding SE (1998) Structure and mucoadhesion of mussel glue protein in dilute solution. Biochemistry 37:14108–14112

    CAS  Google Scholar 

  28. Decker H, Dillinger R, Tuczek F (2000) How does tyrosinase work? Recent insights from model chemistry and structural biology. Angew Chem Int Ed 39:1591–1595

    CAS  Google Scholar 

  29. Demolliens A, Boucher C, Durocher Y, Jolicoeur M, Buschmann MD, De Crescenzo G (2008) Tyrosinase-catalyzed synthesis of a universal coil-chitosan bioconjugate for protein immobilization. Bioconjug Chem 19:1849–1854

    CAS  Google Scholar 

  30. Dinh SM, De Nuzzio JD, Comfort AR (1999) Intelligent materials for controlled release, vol 1. American Chemical Society, Washington, DC, p 13

    Google Scholar 

  31. Dubbink HJ, de Waal L, van Haperen R, Verkaik NS, Trapman J, Romijn JC (1998) The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression and promoter characterization. Genomics 51:434–444

    CAS  Google Scholar 

  32. Ehrbar M, Rizzi SC, Hlushchuk R, Dionov V, Zisch AH, Hubbell JA (2007) Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. Biomaterials 28:3856–3866

    CAS  Google Scholar 

  33. Elisseeff J, Anseth K, Sims D, McIntosh W, Randolph M, Langer R (1999) Transdermal photopolymerization for minimally invasive implantation. Proc Natl Acad Sci 96:3104–3107

    CAS  Google Scholar 

  34. Fenoll LG, Rodriguez-Lopez JN, Varon R, Garcia-Ruiz PA, Garcia-Canovas F, Tudela J (2000) Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols. Biol Chem 381:313–320

    CAS  Google Scholar 

  35. Freddi G, Anghileri A, Sampaio S, Buchert J, Monti P, Taddei P (2006) Tyrosinase-catalyzed modification of Bombyx mori silk fibroin: grafting of chitosan under heterogeneous reaction conditions. J Biotechnol 125(2):281–294

    CAS  Google Scholar 

  36. Galler KM, Aulisa L, Regan KR, D’Souza RN, Hartgerink JD (2010) Self-assembling multidomain peptide hydrogels: designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading. J Am Chem Soc 132(9):3217–3223

    CAS  Google Scholar 

  37. Garcia Y, Wilkins B, Collighan RJ, Griffin M, Pandit A (2008) Towards development of a dermal rudiment for enhanced wound healing response. Biomaterials 29:857–868

    CAS  Google Scholar 

  38. García-Borron JC, Solano F (2002) Molecular anatomy of tyrosinase and its related proteins: Beyond the histidine bound metal catalytic center. Pigment Cell Res 15:162–173

    Google Scholar 

  39. Genove E, Shen C, Zhang S, Semino CE (2005) The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. Biomaterials 26(16):3341–3351

    CAS  Google Scholar 

  40. Gentile P, Chiono V, Boccafoschi F, Baino F, Vitale-Brovarone C, Vernè E, Barbani N, Ciardelli G (2010) Composite films of gelatin and hydroxyapatite/bioactive glass for tissue engineering applications. J Biomed Sci Polym Ed 21:1207–1226

    Google Scholar 

  41. Gerentes P, Vachoud L, Doury J, Domard A (2002) Study of a chitin based gel as injectable material in periodontal surgery. Biomaterials 23:1295–1302

    CAS  Google Scholar 

  42. Grenard P, Bates MK, Aeschlimann D (2001) Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase x and a novel gene family member, transglutaminase z. J Biol Chem 276:33066–33078

    CAS  Google Scholar 

  43. Hansen DC, Corcoran SG, Waite JH (1998) Enzymatic tempering of a mussel adhesive protein film. Langmuir 14:1139–1147

    CAS  Google Scholar 

  44. He JK, Li DC, Liu YX (2009) Preparation of chitosan–gelatin hybrid scaffolds with well-organized microstructures for hepatic tissue engineering. Acta Biomed Source 5(1):453–461

    CAS  Google Scholar 

  45. Healy KE (1999) Molecular engineering of materials for bioreactivity. Curr Opin Solid State Mater Sci 4:381–387

    CAS  Google Scholar 

  46. Healy KE, Rezania A, Stile A (1999) Designing biomaterials to direct biological responses. Ann N Y Acad Sci 875:24–35

    CAS  Google Scholar 

  47. Heggli M, Tirelli N, Zisch A, Hubbell JA (2003) Michael-type addition as a tool for surface functionalization. Bioconj Chem 14:967–973

    CAS  Google Scholar 

  48. Hermanson GT (1996) Bioconjugate techniques. Academic Press, New York

    Google Scholar 

  49. Hirano Y, Mooney DJ (2004) Peptide and protein presenting materials for tissue engineering. Adv Mater 16:17–25

    CAS  Google Scholar 

  50. Hubbell JA (1996) Biomaterials in tissue engineering. Biotechnology 13:565–576

    Google Scholar 

  51. Inada R, Matsi M, Yamada K, Morishima Y, Shen SC, Kuramoto N, Yasuno H, Takahashi K, Miyachi Y, Yamanishi K (2000) Facilitated wound healing by activation of the transglutaminase 1 gene. Am J Pathol 157:1875–1882

    CAS  Google Scholar 

  52. Isaacs BS, Brew SA, Ingham KC (1989) Reversible unfolding of the gelatin-binding domain of fibronectin: structural stability in relation to function. Biochemistry 28:842–855

    CAS  Google Scholar 

  53. Ito A, Mase A, Takizawa Y, Shinkay M, Honda H, Hata KH, Ueda M, Kobayashi T (2003) transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering. J Biosci Bioeng 95(2):196–199

    CAS  Google Scholar 

  54. Jaros D, Partschefeld C, Henle T, Rohm H (2006) Transglutaminase in dairy products: chemistry, physics, applications. J Texture Stud 37:113–155

    Google Scholar 

  55. Jee JG, Park SJ, Kim HJ (2000) Tyrosinase-induced cross-linking of tyrosine-containing peptides investigated by matrix-assisted laser desorption/ionization time of flight mass spectrometry. Rapid Commun Mass Spectrum 14:1563–1567

    CAS  Google Scholar 

  56. Jun HW, West J (2004) Development of a YIGSR-peptide modified polyurethaneurea to enhance endothelialization. J Biomater Sci Polymer Ed 15(1):73–94

    CAS  Google Scholar 

  57. Kanaji T, Ozaki H, Takao T, Kawajiri H, Ide H, Motoki M, Shimonishi Y (1993) Primary structure of microbial transglutaminase from Streptoverticillium sp. strain s-8112. J Biol Chem 268:11565–11572

    CAS  Google Scholar 

  58. Kane JB, Tompkins RG, Yarmush ML, Burke JF (1996) Burn dressings. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) Biomaterials science: an introduction to materials in medicine. Academic Press, San Diego, pp 360–370

    Google Scholar 

  59. Kim SM, Han S (2003) Tyrosinase scavenges tyrosyl radical. Biochem Biophys Res Commun 312(3):642–649

    CAS  Google Scholar 

  60. Klabunde T, Eicken T, Sacchettini JC, Krebs B (1998) Crystal structure of a plant catechol oxidase containing a dicopper center. Nat Struct Biol 5:1084–1090

    CAS  Google Scholar 

  61. Lee BP, Dalsin JL, Messersmith PB (2002) Synthesis and gelation of DOPA-modified poly(ethylene glycol) hydrogels. Biomacromolecules 3(5):1038–1047

    CAS  Google Scholar 

  62. Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101:1869–1879

    Google Scholar 

  63. Lewis KB, Teller DC, Fry J, Lasser GW, Bishop PD (1997) Crosslinking kinetics of the human transglutaminase, factor XIII[A2], acting on fibrin gels and gamma-chain peptides. Biochemistry 36(5):995–1002

    CAS  Google Scholar 

  64. Liu Y, Kopelman D, Wu LQ, Hijji K, Attar I, Preiss-Bloom O, Payne G (2009) Biomimetic sealant based on gelatin and microbial transglutaminase: an initial in vivo investigation. J Biomed Mater Res B Appl Biomater 91:5–16

    Google Scholar 

  65. Lorand L (1950) Fibrin clots. Nature 166(4225):694–695

    CAS  Google Scholar 

  66. Lutolf MP, Hubbell JA (2003) Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules 4:713–722

    CAS  Google Scholar 

  67. Ma PX (2008) Biomimetic materials for tissue engineering. Adv Drug Deliv Rev 60:184–198

    CAS  Google Scholar 

  68. Makarov KS, Aravind L, Koonin EU (1999) A superfamily of archael, bacterial and eukaryotic proteins homologous to animal transglutaminases. Protein Sci 8:1714–1719

    Google Scholar 

  69. Massia SP, Hubbell JA (1992) Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin a4b1. J Biol Chem 267:14019–14026

    CAS  Google Scholar 

  70. Matoba Y, Kumagai T, Yamamoto A, Yoshitsu H, Sugiyama M (2006) Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis. J Biol Chem 281:8981–8990

    CAS  Google Scholar 

  71. Mayo KH (1996) NMR and X-ray studies of collagen model peptides. Biopolymers (Peptide Sci) 40:359–370

    CAS  Google Scholar 

  72. McDermott MK, Chen T, Williams CM, Markley KM, Payne GF (2004) Mechanical properties of biomimetic tissue adhesive based on the microbial transglutaminase-catalyzed crosslinking of gelatin. Biomacromolecules 5:1270–1279

    CAS  Google Scholar 

  73. McGuirl MA, Dooley DM (1999) Copper-containing oxidases. Curr Opin Chem Biol 3:138–144

    CAS  Google Scholar 

  74. Motoki M, Seguro K (1998) Transglutaminase and its use for food processing. Trends Food Sci Technol 9:204–210

    CAS  Google Scholar 

  75. Muzzarelli C, Muzzarelli RAA (2002) Reactivity of quinones towards chitosans. Trends Glycosci Glycotechnol 14:223–229

    CAS  Google Scholar 

  76. O’Halloran DO, Collighan R, Griffin M, Pandit AS (2006) Characterization of a microbial transglutaminase crosslinked type II collagen scaffold. Tissue Eng 12:1467–1474

    Google Scholar 

  77. Paguirigan Amy L, Beebe David J (2007) Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nat Protocols 2(7):1782–1788

    CAS  Google Scholar 

  78. Pasternack R, Dorsch S, Otterbach JT, Robenek IR, Wolf S, Fuchsbauer HL (1998) Bacterial pro-transglutaminase from Streptoverticillium mobaraense. Purification, characterization and sequence of the zymogen. Eur J Biochem 257:570–576

    CAS  Google Scholar 

  79. Peppas NA, Sahlin JJ (1996) Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials 17:1553–1561

    CAS  Google Scholar 

  80. Pisano JJ, Finlayson JS, Peyton MP (1968) Cross-link in fibrin polymerized by factor 13: epsilon-(gamma-glutamyl)lysine. Science 160(830):892–893

    CAS  Google Scholar 

  81. Puszkin EG, Raghuraman V (1995) Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard. J Biol Chem 260:16012–16020

    Google Scholar 

  82. Rezania A, Healy KE (2000) The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells. J Biomed Mater Res 52:595–600

    CAS  Google Scholar 

  83. Richardson TP, Murphy WL, Mooney DJ (2001) Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy. Crit Rev Eukaryot Gene Expr 11:47–58

    CAS  Google Scholar 

  84. Rinaudo M, Pavlov G, Desbrieres J (1999) Influence of acetic acid concentration on the solubilization of chitosan. Polymer 40:7029–7032

    CAS  Google Scholar 

  85. Rowley JA, Mooney DJ (2002) Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res 60:217–222

    CAS  Google Scholar 

  86. Ruoslahti E (1996) RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol 12:697–715

    CAS  Google Scholar 

  87. Sakiyama-Elbert SE, Hubbell JA (2001) Functional biomaterials: design of novel biomaterials. Annu Rev Mater Res 31:183–201

    CAS  Google Scholar 

  88. Sanborn T, Messersmith PB, Barron AE (2002) In situ crosslinking of a biomimetic peptide–PEG hydrogel via thermally triggered activation of Factor XIII. Biomaterials 23:2703–2710

    CAS  Google Scholar 

  89. Sanchez-Ferrer A, Rodriguez-Lopez JN, Garcia-Canovas F, Garcia-Carmona F (1995) Tyrosinase: a comprehensive review of its mechanism. Biochim Biophys Acta 1247:1–11

    Google Scholar 

  90. Sarkar NK, Clarke DD, Waelsch H (1957) An enzymically catalyzed. Incorporation of amines into proteins. Biochim Biophys Acta 25:451–452

    CAS  Google Scholar 

  91. Schense JC, Hubbell JA (1999) Cross-linking exogenous bifunctional peptides into fibrin gels with Factor XIIIa. Bioconjug Chem 10:75–81

    CAS  Google Scholar 

  92. Schmoekel HG, Weber FE, Schense JC, Gratz KW, Schawalder P, Hubbell JA (2005) Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. Biotechnol Bioeng 89:253–262

    CAS  Google Scholar 

  93. Seal BL, Panitch A (2003) Physical polymer matrices based on affinity interactions between peptides and polysaccharides. Biomacromolecules 4:1572–1582

    CAS  Google Scholar 

  94. Shao L, Kumar G, Lenhart JL, Smith PJ, Payne GF (1999) Enzymatic modification of the synthetic polymer polyhydroxystyrene. Enzyme Microbial Technol 25(8):660–668

    CAS  Google Scholar 

  95. Shin H, Jo S, Mikos AG (2002) Modulation of marrow stromal osteoblast adhesion on biomimetic oligo(poly(ethylene glycol) fumarate) hydrogels modified with Arg-Gly-Asp peptides and a poly(ethylene glycol) spacer. J Biomed Mater Res 61:169–179

    CAS  Google Scholar 

  96. Sierra DH, Nissen AJ, Welch J (1990) The use of fibrin glue in intracranial. Laryngoscope 100(4):360–363

    Google Scholar 

  97. Silverman HG, Roberto FF (2007) Understanding marine mussel adhesion. Mar Biotechnol (NY) 9:661–681

    Google Scholar 

  98. Singh RN, Mehta K (1994) Purification and characterization of a novel transglutaminase from filarial nematode Brugia Malayi. Eur J Biochem 225:625–634

    CAS  Google Scholar 

  99. Sobel E, Davanipour Z, Friday G, McCoy R, Levitt L, Isack T (1989) Stroke in the Lehigh Valley: combined risk factors for recurrent ischemic stroke. Neurology 39:669–672

    CAS  Google Scholar 

  100. Sperinde J, Griffith L (2000) Control and prediction of gelation kinetics in enzymatically cross-linked poly(ethylene glycol) hydrogels. Macromolecules 33:5476–5480

    CAS  Google Scholar 

  101. Sugumaran M (1988) Quinone methods and not dehydrodopamine derivatives as reactive intermediates of beta sclerotization in the puparia of flesh fly sarcophaga bullata. Adv Insect Physiol 21:179–231

    CAS  Google Scholar 

  102. Suzuki Y, Tanihara M, Suzuki K, Saitou A, Sufan W, Nishimura Y (2000) Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo. J Biomed Mater Res 50:405–409

    CAS  Google Scholar 

  103. Takai O (2006) Biomimetic nanotechnology. Ann N Y Acad Sci 1093:84–97

    CAS  Google Scholar 

  104. Tan HP, Gong YH, Lao LH, Mao ZW, Gao CY (2007) Gelatin/chitosan/hyaluronan ternary complex scaffold containing basic fibroblast growth factor for cartilage tissue engineering. J Mater Sci Med 18(10):1961–1968

    CAS  Google Scholar 

  105. Tirrell M, Kokkoli E, Biesalski M (2002) The role of surface science in bioengineered materials. Surf Sci 500:61–83

    CAS  Google Scholar 

  106. Villalobos E, Santos M, Talavera D, Rodriguez-Falcòn M, Tornè JM (2004) Molecular cloning and characterization of a maize transglutaminase complementary DNA. Gene 336:93–104

    CAS  Google Scholar 

  107. West JL, Hubbell JA (1999) Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 32:241–244

    CAS  Google Scholar 

  108. Westhaus E, Messersmith PB (2001) controlled release of calcium from lipid vesicles: adaption of a biological strategy for rapid gelation of polysaccharide and protein hydrogels. Biomaterials 22:453–462

    CAS  Google Scholar 

  109. Whitaker MJ, Quirk RA, Howdle SM, Shakesheff KM (2001) Growth factor release from tissue engineering scaffolds. J Pharm Pharmacol 53:1427–1437

    CAS  Google Scholar 

  110. Yamada K, Aoki T, Ikeda N, Hirata M, Hata Y, Higashida K, Nakamura Y (2007) Application of chitosan solutions gelled by melB tyrosinase to water-resistant adhesive. J Appl Polym Sci 107(4):2723–2731

    Google Scholar 

  111. Yamada K, Chen T, Kumar G, Vesnovsky O, Timmie LD, Payne GF (2000) Chitosan based water-resistent adhesive. Analogy to mussel glue. Biomacromolecules 1:252–258

    CAS  Google Scholar 

  112. Yamada Y, Kleinman HK (1992) Functional domains of cell adhesion molecules. Curr Opin Cell Biol 14:819–823

    Google Scholar 

  113. Yasueda H, Kumazawa Y, Motoki M (1994) Purification and characterization of a tissue-type transglutaminase from red sea bream (Pagrus major). Biosci Biotechnol Biochem 58:2041–2045

    CAS  Google Scholar 

  114. Yokohama K, Nio N, Kikuchi Y (2004) Properties and applications of microbial transglutaminase. Appl Microbiol Biotechnol 64:447–454

    Google Scholar 

  115. Zhang J, Masui Y (1997) Role of amphibian egg transglutaminase in the development of secondary cytostatic Factor in vitro. Mol Reprod Dev 47:302–311

    CAS  Google Scholar 

  116. Zhao W, Hang Q, Lin H, Sun W, Gao Y, Zhao Y, Wang B, Wang X (2009) Human basic fibroblast growth factor fused with Kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis. Tissue Eng A 15(5):991–998

    CAS  Google Scholar 

  117. Zhu Y, Rinzema A, Tramper H, Bol J (1995) Microbial transglutaminase—a review of its production and application in food processing. Appl Microbiol Biotechnol 44:277–282

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy

    Piergiorgio Gentile, Valeria Chiono, Chiara Tonda-Turo, Susanna Sartori & Gianluca Ciardelli

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  1. Piergiorgio Gentile
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Correspondence to Gianluca Ciardelli .

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  1. Technical University Graz, Institut für Umweltbiotechnologie, Petersgasse 12/I, Graz, 8010, Austria

    Gibson Stephen Nyanhongo

  2. Technical University Graz, Institut für Biotechnologie und Bioproze, Petersgasse 12/I, Graz, 8010, Austria

    Walter Steiner

  3. Technical University Graz, Institut für Umweltbiotechnologie, Petersgasse 12/I, Graz, 8010, Austria

    Georg Gübitz

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Gentile, P., Chiono, V., Tonda-Turo, C., Sartori, S., Ciardelli, G. (2010). Biomimetic Materials for Medical Application Through Enzymatic Modification. In: Nyanhongo, G., Steiner, W., Gübitz, G. (eds) Biofunctionalization of Polymers and their Applications. Advances in Biochemical Engineering / Biotechnology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2010_85

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