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Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair pp 273–288Cite as

The Measurement of Systolic Function in the Mammalian Heart

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4. Summary

The heart is a muscular pump that generates force in order to do work and pump volume. The major determinants of its ability to perform these functions are its size, mass, innate strength or contractility, preload and afterload. While all of these parameters should be kept in mind when assessing cardiac function, assessment of most pathologies and therapies rely on measuring contractility. Despite major advances in our understanding of cardiac function over the past 50 years, a simple, easily applied and accurate measure of contractility still eludes us. Easily applied measures lack sensitivity and accuracy while complex measures are cumbersome and difficult to apply. These principles must be kept in full view in order to avoid errors in assessing cardiac function.

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Authors and Affiliations

  1. Department of Medicine and the Michael E. DeBakey Veterans Affairs Medica Center, Baylor College of Medicine, Houston, Texas, 77030

    Blasé A. Carabello

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  1. Blasé A. Carabello
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Editors and Affiliations

  1. Arizona Heart Institute, 2632 North 20th Street, Phoenix, AZ, 85006, USA

    Nabil Dib MD, MSc, FACC (Director of Cardiovascular Research) & Edward B. Diethrich MD (Medical Director) (Director of Cardiovascular Research) &  (Medical Director)

  2. Center for Cardiovascular Repair, University of Minnesota, Minneapolis, MN, USA

    Doris A. Taylor PhD (Director) (Director)

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© 2006 Springer Science+Business Media, Inc.

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Carabello, B.A. (2006). The Measurement of Systolic Function in the Mammalian Heart. In: Dib, N., Taylor, D.A., Diethrich, E.B. (eds) Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair. Springer, Boston, MA. https://doi.org/10.1007/0-387-30939-X_18

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  • DOI: https://doi.org/10.1007/0-387-30939-X_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25788-4

  • Online ISBN: 978-0-387-30939-2

  • eBook Packages: EngineeringEngineering (R0)

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