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Asphyxia

  • Chapter
Therapeutic Hypothermia

Part of the book series: Molecular and Cellular Biology of Critical Care Medicine ((MCCM,volume 4))

Abstract

The first resuscitation societies, founded in the mid-18th century, were organized networks of rescuers responding primarily to drowning victims. In the 19th century, the development of general anesthesia and its attendant airway mishaps generated additional enthusiasm for preventing, understanding, and treating asphyxia. Thus, asphyxia was the main focus of early resuscitation science. More recently however, sudden collapse, primarily as a result of cardiac arrhythmia, has become the focus of resuscitation research and interventions. Reasons for focusing on sudden arrhythmic death include: 1) arrhythmia is more common than asphyxia as a cause of death in adults, 2) when the collapse is sudden and witnessed there is a precise epidemiologic definition for start and duration of ischemia, and 3) defibrillators for treatment of ventricular fibrillation (VF) or ventricular tachycardia (VT) have been developed and deployed worldwide. In addition, prospective clinical trials are strengthened by the selection of relatively homogenous patient populations and the use of discrete, measurable outcomes (e.g. defibrillation). Accordingly, the recently performed clinical trials of induced hypothermia following cardiac arrest (discussed in Chapter 2) excluded asphyxial arrest and limited enrollment to a highly-selected population of patients resuscitated from VF/VT.

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Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Robert W. Hickey MD & Clifton W. Callaway MD, PhD

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  1. Robert W. Hickey MD
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  2. Clifton W. Callaway MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Critical Care, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Samuel A. Tisherman MD

  2. Emergency Medicine, Medical University of Vienna, 1090, Vienna, Austria

    Fritz Sterz MD

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Hickey, R.W., Callaway, C.W. (2005). Asphyxia. In: Tisherman, S.A., Sterz, F. (eds) Therapeutic Hypothermia. Molecular and Cellular Biology of Critical Care Medicine, vol 4. Springer, Boston, MA. https://doi.org/10.1007/0-387-25403-X_8

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  • DOI: https://doi.org/10.1007/0-387-25403-X_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25402-9

  • Online ISBN: 978-0-387-25403-6

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