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Hemorrhagic Fever Viruses as Biological Weapons

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Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century

Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC))

7. Conclusions

In addition to causing illness and death, a biological attack would aim to cause fear in the general populace and, thus, result in social and economic disruption. Based on their fearsome reputation and dramatization by the popular media, VHF agents would be excellent candidates to serve this purpose. Given the potential for a biological attack to occur, it is of the utmost importance that resources and knowledge are made available to deal effectively with such a situation in a safe and timely manner.

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References

  • Alibek, K., and Handelman, S. (1999). Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World, Told from the Inside by the Man Who Ran It. Random House, New York.

    Google Scholar 

  • Bazhutin, N., Belanov, E., Spiridonov, V., Voitenko, A., Krivenchuk, N., Krotov, S., Omel’chenko, N., Tereshchenko, A., and Khomichev, V. (1992). The effect of the methods for producing an experimental Marburg virus infection on the characteristics of the course of the disease in green monkeys. Vopr. Virusol. 37:153–156.

    PubMed  CAS  Google Scholar 

  • Belanov, E., Muntianov, V., Kriuk, V., Sokolov, A., Bormotov, N., P’iankov, O., and Sergeev, A. (1996). Survival of Marburg virus infectivity on contaminated surfaces and in aerosols. Vopr. Virusol. 41:32–34.

    PubMed  CAS  Google Scholar 

  • Borio, L., Inglesby, T., Peters, C., Schmaljohn, A., Hughes, J., Jahrling, P., Ksiazek, T., Johnson, K., Meyerhoff, A., Toole, T., Ascher, M., Bartlett, J., Breman, J., Eitzen, E. Jr., Hamburg, M., Hauer, J., Henderson, D., Johnson, R., Kwik, G., Layton, M., Lillibridge, S., Nabel, G., Osterholm, M., Perl, T., Russell, P., and Tonat, K. [Working Group on Civilian Biodefense]. (2002). Hemorrhagic fever viruses as biological weapons: medical and public health management. J.A.M.A. 287:2391–2405.

    PubMed  Google Scholar 

  • Bray, M., Davis, K., Geisbert, T., Schmaljohn, C., and Huggins, J. (1998). A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178:651–661.

    PubMed  CAS  Google Scholar 

  • Brown, J., Dominik, J., and Morrissey, R. (1981). Respiratory infectivity of a recently isolated Egyptian strain of Rift Valley fever virus. Infect. Immun. 33:848–853.

    PubMed  CAS  Google Scholar 

  • Buckley, S., and Casals, J. (1970). Lassa fever, a new virus disease of man from West Africa. 3. Isolation and characterization of the virus. Am. J. Trop. Med. Hyg. 19:680–691.

    PubMed  CAS  Google Scholar 

  • Center for Nonproliferation Studies. (2000). Chemical and biological weapons: Possession and programs past and present. http://www.cns.miis.edu/research/cbw/possess.htm

    Google Scholar 

  • Centers for Disease Control and Prevention. (2001). Outbreak of Ebola hemorrhagic fever, Uganda, August 2000–January 2001. MMWR Morb. Mort. Wkly. Rep. 50:73–77.

    Google Scholar 

  • Centers for Disease Control and Prevention. (1994). Arenavirus infection—Connecticut, 1994. MMWR Morb. Mort. Wkly. Rep. 43:635–636.

    Google Scholar 

  • Centers for Disease Control and Prevention (2000). Biological and chemical terrorism: Strategic plan for preparedness and response. Recommendations of the CDC Strategic Planning Workgroup. MMWR Recomm. Rep. 49:1–14.

    Google Scholar 

  • Colebunders, R., and Borchert, M. (2000). Ebola haemorrhagic fever-a review. J. Infect. 40:16–20.

    Article  PubMed  CAS  Google Scholar 

  • Cosgriff, T., Morrill, J., Jennings, G., Hodgson, L., Slayter, M., Gibbs, P., and Peters, C. (1989). Hemostatic derangement produced by Rift Valley fever virus in rhesus monkeys. Rev. Infect. Dis. 11(Suppl 4):S807–S814.

    PubMed  Google Scholar 

  • Cummins, D., Bennett, D., Fisher-Hoch, S., Farrar, B., Machin, S., and McCormick, J. (1992). Lassa fever encephalopathy: clinical and laboratory findings. J. Trop. Med. Hyg. 9:197–201.

    Google Scholar 

  • Cummins, D., McCormick, J., Bennett, D., Samba, J., Farrar, B., Machin, S., and Fisher-Hoch, S. (1990a). Acute sensorineural deafness in Lassa fever. J.A.M.A. 264:2119.

    Google Scholar 

  • Cummins, D., Molinas, F., Lerer, G., Maiztegui, J., Faint, R., and Machin, S. (1990b). A plasma inhibitor of platelet aggregation in patients with Argentine hemorrhagic fever. Am. J. Trop. Med. Hyg. 42:470–475.

    PubMed  CAS  Google Scholar 

  • de Bracco, M., Rimoldi, M., Cossio, P., Rabinovich, A., Maiztegui, J., Carballal, G., and Arana, R. (1978). Argentine hemorrhagic fever. Alterations of the complement system and anti-Junin-virus humoral response. N. Engl. J. Med. 299:216–221.

    Article  PubMed  Google Scholar 

  • Dowell, S., Mukunu, R., Ksiazek, T., Kahn, A., Rollin, P., and Peters, C. (1995). Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo. J. Infect. Dis. 179(Suppl 1): S87–S91.

    Google Scholar 

  • Enria, D., Briggiler, A., Fernandez, N., Levis, S., and Maiztegui, J. (1984). Importance of dose of neutralising antibodies in treatment of Argentine haemorrhagic fever with immune plasma. Lancet 2:255–256.

    Article  PubMed  CAS  Google Scholar 

  • Enria, D., and Maiztegui, J. (1994). Antiviral treatment of Argentine hemorrhagic fever. Antiviral Res. 23:23–31.

    Article  PubMed  CAS  Google Scholar 

  • Feldmann, H., Jones, S., Klenk, H.-D., and Schnittler, H. (2003). Ebola virus: from discovery to vaccine. Nat. Rev. Immunol. 3:677–685.

    Article  PubMed  CAS  Google Scholar 

  • Fisher-Hoch, S., Platt, G., Neild, G., Southee, T., Baskerville, A., Raymond, R., Lloyd, G., and Simpson, D. (1985). Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Infect. Dis. 152:887–894.

    PubMed  CAS  Google Scholar 

  • Frame, J., Verbrugge, G., Gill, R., and Pinneo, L. (1984). The use of Lassa fever convalescent plasma in Nigeria. Trans. R. Soc. Trop. Med. Hyg. 78:319–324.

    Article  PubMed  CAS  Google Scholar 

  • Garbutt, M., Liebscher, R., Wahl-Jensen, V., Jones, S., Moeller, P., Wagner, R., Volchkov, V., Klenk, H.D., Feldmann, H., and Stroeher, U. (2004). Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. J. Virol. 78:5458–5465.

    Article  PubMed  CAS  Google Scholar 

  • Gargan, T. 2nd, Clark, G., Dohm, D., Turell, M., and Bailey, C. (1988). Vector potential of selected North American mosquito species for Rift Valley fever virus. Am. J. Trop. Med. Hyg. 38:440–446.

    PubMed  Google Scholar 

  • Geisbert, T., Hensley, L., Jahrling, P., Larsen T., Geisbert, J., Paragas, J., Young, H., Fredeking, T., Rote, W., and Vlasuk, G. (2003). Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 362:1953–1958.

    Article  PubMed  CAS  Google Scholar 

  • Geisbert, T., Pushko, P., Anderson, K., Smith, J., Davis, K., and Jahrling, P. (2002). Evaluation in nonhuman primates of vaccines against Ebola virus. Emerg. Infect. Dis. 8:503–507.

    PubMed  Google Scholar 

  • Global Proliferation of Weapons of Mass Destruction (1996). Hearings Before the Permanent Subcommittee on Investigations of the Committee on Governmental Affairs, United States Senate, 104th Cong, 1st and 2nd Sess.

    Google Scholar 

  • Harrison, L., Halsey, N., McKee, K., Peters, C., Barrera Oro, J., Briggiler, A., Feuillade, M., Maiztegui, J. (1999). Clinical case definitions for Argentine hemorrhagic fever. Clin. Infect. Dis. 28:1091–1094.

    PubMed  CAS  Google Scholar 

  • Hart, M. (2003). Vaccine research efforts for filoviruses. Int. J. Parasitol. 33:583–595.

    Article  PubMed  CAS  Google Scholar 

  • Hensley, L., Young, H., Jahrling, P., and Geisbert, T. (2002). Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol. Lett. 80:169–179.

    Article  PubMed  CAS  Google Scholar 

  • Huggins, J. (1989). Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug. Rev. Infect. Dis. 11(Suppl 4):S750–S761.

    PubMed  CAS  Google Scholar 

  • Huggins, J., Zhang, Z., and Bray, M. (1999). Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J. Infect. Dis. 179(Suppl 1):S240–S247.

    PubMed  CAS  Google Scholar 

  • Jaax, N., Davis, K., Geisbert, T., Vogel, P., Jaax, G., Topper, M., and Jahrling, P. (1996). Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch. Pathol. Lab. Med. 120:140–155.

    PubMed  CAS  Google Scholar 

  • Jahrling, P., Peters, C., and Stephen, E. (1984). Enhanced treatment of Lassa fever by immune plasma combined with ribavirin in cynomolgus monkeys. J. Infect. Dis. 149:420–427.

    PubMed  CAS  Google Scholar 

  • Johnson, K., Kuns, M., Mackenzie, R., Webb, P., and Yunker, C. (1966). Isolation of Machupo virus from wild rodent Calomys callosus. Am. J. Trop. Med. Hyg. 15:103–106.

    PubMed  CAS  Google Scholar 

  • Johnson, K., Mackenzie, R., Webb, P., and Kuns, M. (1965). Chronic infection of rodents by Machupo virus. Science. 150:1618–1619.

    PubMed  CAS  Google Scholar 

  • Jones, S., Geisbert, T., Ströher, U., Geisbert, J., Bray, M., Jahrling, P., Geisbert, T., and Feldmann, H. (2003). Replicating vectors for vaccine development. Symposium on Viral hemorrhagic Fevers, Vaccine Research Center, NIAID, NIH, DHHS, Bethesda, Md.

    Google Scholar 

  • Jouan, A., Coulibaly, I., Adam, F., Philippe, B., Riou, O., Leguenno, B., Christie, R., Ould Merzoug, N., Ksiazek, T., and Digoutte, J. (1989). Analytical study of a Rift Valley fever epidemic. Res. Virol. 140:175–186.

    PubMed  CAS  Google Scholar 

  • Kaplan, D. (2000). Aum Shinrikyo. In: Tucker, J. (ed.), Toxic Terror: Assessing Terrorist Use of Chemical and Biological Weapons. MIT Press, Cambridge, mass., pp. 207–226.

    Google Scholar 

  • Kenyon, R., McKee, K. Jr., Zack, P., Rippy, M., Vogel, A., York, C., Meegan, J., Crabbs, C., and Peters, C. (1992). Aerosol infection of rhesus macaques with Junin virus. Intervirology 33:23–31.

    PubMed  CAS  Google Scholar 

  • Knobloch, J., McCormick, J., Webb, P., Dietrich, M., Schumacher, H., and Dennis, E. (1980). Clinical observations in 42 patients with Lassa fever. Tropenmed. Parasitol. 31:389–398.

    PubMed  CAS  Google Scholar 

  • LeDuc, J. (1989). Epidemiology of hemorrhagic fever viruses. Rev. Infect. Dis. 11(Suppl 4):S730–S735.

    PubMed  Google Scholar 

  • Maiztegui, J., McKee, K. Jr., Barrera Oro J., Harrison, L., Gibbs, P., Feuillade, M., Enria, D., Briggiler, A., Levis, S., Ambrosio, A., Halsey, N., and Peters, C. (1998). Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group. J. Infect. Dis. 177:277–283.

    Article  PubMed  CAS  Google Scholar 

  • Martini, G. (1969). Marburg agent disease in man. Trans. R. Soc. Trop. Med. Hyg. 63:295–302.

    Article  PubMed  CAS  Google Scholar 

  • McCormick, J., King, I., Webb, P., Johnson, K., O’Sullivan, R., Smith, E., Trippel, S., and Tong, T. (1987). A case-control study of the clinical diagnosis and course of Lassa fever. J. Infect. Dis. 155:445–455.

    PubMed  CAS  Google Scholar 

  • McKee, K. Jr., Huggins, J., Trahan, C., and Mahlandt, B. (1988). Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever. Antimicrob. Agents Chemother. 32:1304–1309.

    PubMed  CAS  Google Scholar 

  • Meegan J., and Shope, R. (1981). Emerging concepts on Rift Valley fever. Perspect. Virol. 11:267–387.

    Google Scholar 

  • Miller, J., Engelberg, S., and Broad, W. (2002). Germs: Biological Weapons and America’s Secret War. GK Hall, Waterville, Me.

    Google Scholar 

  • Murphy, F., Simpson, D., Whitfield, S., Zlotnik, I., and Carter, G. (1971). Marburg virus infection in monkeys. Ultrastructural studies. Lab. Invest. 24:279–291.

    PubMed  CAS  Google Scholar 

  • Neumann, G., Feldmann, H., Watanabe, S., Lukashevich, I., and Kawaoka, Y. (2002). Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture. J. Virol. 76:406–410.

    Article  PubMed  CAS  Google Scholar 

  • Peters, C., Jones, D., Trotter, R., Donaldson, J., White, J., Stephen, E., and Slone, T. Jr. (1988). Experimental Rift Valley fever in rhesus macaques. Arch. Virol. 99:31–44.

    Article  PubMed  CAS  Google Scholar 

  • Peters, C., Liu, C., Anderson, G. Jr, Morrill, J., and Jahrling, P. (1989). Pathogenesis of viral hemorrhagic fevers: Rift Valley fever and Lassa fever contrasted. Rev. Infect. Dis. 11(Suppl 4):S743–S749.

    PubMed  Google Scholar 

  • Peters, C., and Zaki, S. (2002). Role of the endothelium in viral hemorrhagic fevers. Crit. Care Med. 30(Suppl 5):S268–S273.

    Article  PubMed  Google Scholar 

  • Pittman, P., Liu, C., Cannon, T., Makuch, R., Mangiafico, J., Gibbs, P., and Peters, C. (1999). Immunogenicity of an inactivated Rift Valley fever vaccine in humans: a 12-year experience. Vaccine 18:181–189.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez, L., De Roo, A., Guimard, Y., Trappier, S., Sanchez, A., Bressler, D., Williams, A., Rowe, A., Bertolli, J., Khan, A., Ksiazek, T., Peters, C., and Nichol, S. (1999). Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. 179(Suppl 1):S170–S176.

    PubMed  CAS  Google Scholar 

  • Roels, T., Bloom, A., Buffington, J., Muhungu, G., MacKenzie, W., Khan, A., Ndambi, R., Noah, D., Rolka, H., Peters, C., and Ksiazek, T. (1999). Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure. J. Infect. Dis. 179(Suppl 1):S92–S97.

    PubMed  Google Scholar 

  • Samoilovich, S., Carballal, G., and Weissenbacher, M. (1983). Protection against a pathogenic strain of Junin virus by mucosal infection with an attenuated strain. Am. J. Trop. Med. Hyg. 32:825–828.

    PubMed  CAS  Google Scholar 

  • Schnittler, H., and Feldmann, H. (2003). Viral hemorrhagic fever — a vascular disease. Thromb. Haemost. 89:967–972.

    PubMed  CAS  Google Scholar 

  • Schnittler, H., and Feldmann, H. (1998). Marburg and Ebola hemorrhagic fevers: does the primary course of infection depend on the accessibility of organ-specific macrophages? Clin. Infect. Dis. 27:404–406.

    Article  PubMed  CAS  Google Scholar 

  • Simpson, D. (1969). Marburg agent disease. Trans. R. Soc. Trop. Med. Hyg. 63:303–309.

    Article  PubMed  CAS  Google Scholar 

  • Slenczka, W. (1999). The Marburg virus outbreak of 1967 and subsequent episodes. Curr. Top. Microbiol. Immunol. 235:49–75.

    PubMed  CAS  Google Scholar 

  • Smithburn, K., Mahaffy, A., Haddow, A., Kitchen, S., and Smith, J. (1949). Rift Valley fever: accidental infection among laboratory workers. J. Immunol. 62:213–227.

    PubMed  CAS  Google Scholar 

  • Stephenson, E., Larson, E., Dominik, J. (1984). Effect of environmental factors on aerosol-induced Lassa virus infection. J. Med. Virol. 14:295–303.

    PubMed  CAS  Google Scholar 

  • Ströher, U., West, E., Bugany, H., Klenk, H.-D., Schnittler, H., and Feldmann, H. (2001). Infection and activation of monocytes by Marburg and Ebola viruses. J. Virol. 75:11025–11033.

    Article  PubMed  Google Scholar 

  • Sullivan, N., Geisbert, T., Geisbert, J., Xu, L., Yang, Z., Roederer, M., Koup, R., Jahrling, P., and Nabel, G. (2003). Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Nature 424:681–684.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, N., Sanchez, A., Rollin, P., Yang, Z., and Nabel, G. (2000). Development of a preventive vaccine for Ebola virus infection in primates. Nature. 408:605–609.

    Article  PubMed  CAS  Google Scholar 

  • Swanapoel, R., and Coetzer, J. (1994). Rift Valley Fever. In: Infectious Diseases of Livestock With Special Reference to Southern Africa. New York, Oxford University Press.

    Google Scholar 

  • Swanepoel, R., Shepherd, A., Leman, P., Shepherd, S., McGillivray, G., Erasmus, M., Searle, L., and Gill, D. (1987). Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am. J. Trop. Med. Hyg. 36:120–32.

    PubMed  CAS  Google Scholar 

  • ter Meulen, J., Lukashevich, I., Sidibe, K., Inapogui, A., Marx, M., Dorlemann, A., Yansane, M., Koulemou, K., Chang-Claude, J., and Schmitz, H. (1996). Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea. Am. J. Trop. Med. Hyg. 55:661–666.

    PubMed  Google Scholar 

  • Vainrub B, and Salas R. (1994). Latin American hemorrhagic fever. Infect. Dis. Clin. North. Am. 8:47–59.

    PubMed  CAS  Google Scholar 

  • van Eeden, P., van Eeden, S., Joubert, J., King, J., van de Wal, B., and Michell, W. (1985). A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part II. Management of patients. S. Afr. Med. J. 68:718–721.

    PubMed  Google Scholar 

  • Villinger, F., Rollin, P., Brar, S., Chikkala, N., Winter, J., Sundstrom, J., Zaki, S., Swanepoel, R., Ansari, A., and Peters, C. (1999). Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J. Infect. Dis. 179(Suppl 1):S188–S191.

    PubMed  CAS  Google Scholar 

  • Volchkov, V., Volchkova, V., Muhlberger, E., Kolesnikova, L., Weik, M., Dolnik, O., and Klenk, H.-D. (2001). Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity. Science 291:1965–1969.

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization. (1978). Ebola hemorrhagic fever in Zaire, 1976. Bull. World Health Org. 56:271–293.

    Google Scholar 

  • Zaki, S., and Goldsmith, C. (1999). Pathologic features of filovirus infection in humans. Curr. Top. Microbiol. Immunol. 235:97–115.

    PubMed  CAS  Google Scholar 

  • Zaki, S., Shieh, W., Greer, P., Goldsmith, C., Ferebee, T., Katshitshi, J., Tshioko, F., Bwaka, M., Swanepoel, R., Calain, P., Khan, A., Lloyd, E., Rollin, P., Ksiazek, T., and Peters, C. (1999). A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. J. Infect. Dis. 179(Suppl 1):S36–S47.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada

    Allison Groseth, Steven Jones, Harvey Artsob & Heinz Feldmann

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  1. Allison Groseth
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  2. Steven Jones
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  3. Harvey Artsob
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  4. Heinz Feldmann
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Editors and Affiliations

  1. St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

    I. W. Fong

  2. The National Center for Biodefense, George Mason University, Manassas, Virginia

    Kenneth Alibek

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Groseth, A., Jones, S., Artsob, H., Feldmann, H. (2005). Hemorrhagic Fever Viruses as Biological Weapons. In: Fong, I.W., Alibek, K. (eds) Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century. Emerging Infectious Diseases of the 21st Century. Springer, Boston, MA. https://doi.org/10.1007/0-387-23685-6_6

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