Reprogramming of Tumor Microenvironment and Enhancement of Immune Responses in Gastrointestinal Cancers

Gastrointestinal cancers pose a significant health challenge worldwide, and the development of effective treatment strategies is of paramount importance. The tumor microenvironment plays a crucial role in the progression of gastrointestinal cancers, influencing tumor growth, invasion, and response to therapy. Additionally, the interplay between tumor cells and the immune system within the tumor microenvironment has a profound impact on disease outcomes. This Collection aims to shed light on the reprogramming of the tumor microenvironment and the enhancement of immune responses in gastrointestinal cancers. It will feature cutting-edge research and review articles that explore innovative approaches to modulate the tumor microenvironment and harness the immune system to combat gastrointestinal cancers. Topics of interest for this Collection include, but are not limited to: 1) Novel immunotherapeutic strategies targeting gastrointestinal cancers; 2) Immune checkpoint inhibitors and their application in gastrointestinal cancer treatment; 3) Reprogramming the tumor microenvironment to enhance anti-tumor immune responses; 4) Biomarkers for predicting immune responses in gastrointestinal cancers; 5) Immunomodulatory therapies for specific subtypes of gastrointestinal cancers; 6) Combination therapies involving immunotherapy and conventional treatment modalities; 7) Preclinical and clinical studies evaluating the efficacy of immune-based interventions in gastrointestinal cancers.

We welcome submissions that will provide valuable insights into the reprogramming of the tumor microenvironment and the enhancement of immune responses as promising avenues for the development of more effective treatments for gastrointestinal cancers. Researchers and clinicians are encouraged to contribute their original findings and perspectives to foster a deeper understanding of this rapidly evolving area of cancer research.

Keywords: immune response, tumor microenvironment reprogramming, gastrointestinal cancers, molecular signaling, therapeutics