EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability
Authors (first, second and last of 5)
Collection
Onco-proteogenomics
With the advancement of sequencing technologies, whole genome sequence information can be obtained robustly in a fairly short time and at low cost. Yet, currently there is often a lack of connection of genomic data to proteomic data, probably due to the fact that standard proteomics workflows rely on databases of only known wild-type/canonical proteins, but these databases generally do not integrate the data of cancer-associated proteins with countless amino acid sequence alterations due to gene mutations, post-translational modifications, and aberrant chromosome rearrangement. Therefore, in the next phase, it becomes extremely important to integrate experimentally-generated Mass Spectrometric data accordingly with the genomic information to identify tumor-specific proteins and isoforms.
Onco-proteogenomics has great promise and holds the key in improving our understanding of cancer biology and it is anticipated that the routine utilization of this integrated omics approach would become one of the gold standards of precision oncology. In this collection, we welcome original articles focusing on cancer proteogenomics research.
Articles (28 in this collection)
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New insights into targeted therapy of glioblastoma using smart nanoparticles
Authors (first, second and last of 6)
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RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
Authors (first, second and last of 11)
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The upregulation of VGF enhances the progression of oral squamous carcinoma
Authors (first, second and last of 6)
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Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Authors (first, second and last of 7)
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Mitochondrial respiratory chain component NDUFA4: a promising therapeutic target for gastrointestinal cancer
Authors (first, second and last of 7)
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STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Authors (first, second and last of 10)
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RhoB expression associated with chemotherapy response and prognosis in colorectal cancer
Authors (first, second and last of 11)
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Omics-based molecular classifications empowering in precision oncology
Authors (first, second and last of 11)
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EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition
Authors (first, second and last of 6)
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Identification of a new gene signature for prognostic evaluation in cervical cancer: based on cuproptosis-associated angiogenesis and multi-omics analysis
Authors (first, second and last of 6)
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Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments
Authors (first, second and last of 6)
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Clinical applications and perspectives of circulating tumor DNA in gastric cancer
Authors (first, second and last of 4)
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RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
Authors (first, second and last of 8)
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A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma
Authors (first, second and last of 8)
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miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability
Authors (first, second and last of 7)
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Circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective
Authors (first, second and last of 6)
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CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
Authors (first, second and last of 6)
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Leveraging a disulfidptosis/ferroptosis-based signature to predict the prognosis of lung adenocarcinoma
Authors (first, second and last of 8)
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Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis
Authors (first, second and last of 15)
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Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population
Authors (first, second and last of 16)
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FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway
Authors (first, second and last of 10)
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DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress
Authors (first, second and last of 11)
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Enhancing prognostic accuracy in head and neck squamous cell carcinoma chemotherapy via a lipid metabolism-related clustered polygenic model
Authors (first, second and last of 14)
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Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments
Authors (first, second and last of 5)
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miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
Authors (first, second and last of 7)
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FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling
Authors (first, second and last of 8)
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Lymphocyte antigen 6G6D-mediated modulation through p38α MAPK and DNA methylation in colorectal cancer
Authors (first, second and last of 9)
