Collection
Accelerating Multiple Myeloma System Biology Research
Multiple myeloma (MM) is a haematological malignancy characterized by clonal proliferation of plasma cells in the bone marrow microenvironment. Despite improved survival, MM is still incurable. The interaction between the bone marrow microenvironment and multiple myeloma plasma cells (MMPCs) influences cellular growth and survival, drug resistance, intra-/extra-medullary disease (EMD), and ultimately disease prognosis. Spreading of MMPCs throughout bone marrow (BM) niche and EMD sites, as well PC leukemia (PCL), is an active process involving BM endothelial cells, adhesion molecules, and chemokine receptors. Profiling the intra/extra-MM genomic landscape and resolving its spatial architecture have the potential to uncover the complexities of MM, thus addressing outstanding questions in its biology and potentially leading to the identification of new pharmacological opportunities.
This Collection will focus on the application of new high-throughput, high-resolution technologies from the omics field for dissecting the inter- and intra-MM heterogeneity and its translational implication. We encourage Original Research and Review papers focusing on, but not limited to, the following aspects: 1) State of the art and emerging techniques for studying Multiple Myeloma. 2) Omics-based investigations (such as genomics, transcriptomic, proteomics and metabolomics) and multi-omics approaches applied to Multiple Myeloma. 3) Spatial multimodal omics and potential for application in Multiple Myeloma. 4) Bioinformatics and network-based biology analysis in Multiple Myeloma. 5) System Biology in Multiple Myeloma. 6) Trends, challenges, and pitfalls in the field.
Keywords: multiple myeloma, microenvironment, cell-cell communication, system biology, omics, biomarker and target identification
Editors
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Antonio Giovanni Solimando
PhD, University of Bari Aldo Moro, Italy.
Graduated from Bari Medical School University, Italy, in 2011, Internal Medicine Specialist, is an attendant physician, Clinical and Research Scientist in internal medicine since 2012. Focusing on the field of hematology he investigates the interactions of multiple myeloma and the tumor microenvironment. To gain better insights into these complex processes he employs state-of-the-art imaging techniques to ultimately translate his findings into improved diagnostics and therapies. Dr. Solimando is an academic researcher, Assistant Professor at Bari University (Italy).
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Simona D’Amore
PhD, University of Bari Aldo Moro, Italy.
Dr. D’Amore specializes in Internal Medicine, focusing on inflammation's role in metabolism and cancer. With a PhD in translational medicine, she investigates the connections between metabolic syndrome, inflammation, and cancer regulation. At the University of Cambridge, her post-doc work concentrated on metabolic disorders, particularly bone manifestations and biomarker discovery. Currently, she serves as an academic researcher and Assistant Professor at Bari University, emphasizing rare disorders' link with hematological cancers and seeking novel biomarkers for patient stratification.
