Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo
Authors (first, second and last of 8)
Collection
Special Issue: Oxygen Sensors – HIF-Hydroxylases in Physiology, Pathophysiology and Pharmacology
The cellular response to life-threatening lack of oxygen, hypoxia, has stimulated physiologist to study oxygen sensing in cells and tissue. The discovery of the transcription factor hypoxia inducible factor (HIF) and how cells sense oxygen availability through HIF-hydroxylases was awarded with the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe and William G. Kaelin Jr. We now encourage contributions on cellular hypoxic responses that go beyond the classical HIF-dependent transcription. We invite you to contribute to our special issue by original reports or overview articles how hypoxic-inducible factor (HIF) hydroxylases are affected in physiology, e.g. by hypoxia, in pathophysiology, e.g. inflammation, or pharmacology, e.g. prolyl hydroxylase inhibitors.
Submissions will undergo a regular review process.
Editors
-
Dr. Joachim Fandrey
Institute for Physiology, University of Duisburg-Essen, Germany
Articles (6 in this collection)
-
-
-
-
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Authors (first, second and last of 19)
-
Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis
Authors (first, second and last of 5)
-
Cargo-specific effects of hypoxia on clathrin-mediated trafficking
Authors (first, second and last of 8)
