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Dendritic Cells

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Immunotherapy of Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Dendritic cells (DCs) have been called “nature’s adjuvant” because of their remarkable ability to elicit adaptive, antigen-specific immunity. Immature DCs are highly specialized to capture antigens, but are poor at priming or activating T-cells. Following antigen capture or in a proinflammatory environment, DCs undergo a process of maturation in which antigen-carrying capacity is greatly reduced as T-cell priming and activating capacity are increased.

DCs are tightly regulated by expression of chemokine receptors whose expression varies according to the maturation state, microenvironmental milieu, and type of DC. Three principal subsets of human DCs are recognized: Langerhans’ DCs, myeloid DCs, and plasmacytoid DCs. Much is now known regarding the lineage origins and specialized functions of these subsets, although much remains to be learned, and controversies abound.

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Authors and Affiliations

  1. Section of Hematology and Medical Oncology, Department of Medicine, Tulane Medical School, New Orleans, LA

    Weiping Zou MD, PhD & Tyler J. Curiel MD, MPH (The Henderson Professor of Medicine, Chief)

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  1. Weiping Zou MD, PhD
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  2. Tyler J. Curiel MD, MPH
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Editors and Affiliations

  1. University of Washington School of Medicine, Seattle, WA

    Mary L. Disis MD

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© 2006 Humana Press Inc., Totowa, NJ

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Zou, W., Curiel, T.J. (2006). Dendritic Cells. In: Disis, M.L. (eds) Immunotherapy of Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59745-011-1:115

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