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Immunotherapy of Cancer pp 87–114Cite as

DNA Vaccines for Cancer Immunotherapy

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The introduction of selected genes by direct injection of DNA represents a general strategy for short-term gene expression in vivo. DNA vaccines may be especially useful for cancer immunotherapy because DNA allows transient expression of tumor-associated antigens and immunostimulatory proteins by a relatively nonimmunogenic vector. This chapter focuses on how DNA vaccines stimulate immune responses and how different immunization strategies may result in various types of immunity. The inclusion of chemical and genetic adjuvants as methods for enhancing DNA vaccination is also discussed. The methods currently available for constructing DNA vaccines and the implications for cancer therapy will be reviewed. Finally, some of the safety and ethical concerns generated by DNA vaccination are presented.

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Authors and Affiliations

  1. Departments of Surgery and Pathology, College of Physicians and Surgeons, Columbia University, New York, NY

    Heesun Kwak PhD & Howard L. Kaufman MD

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  1. Heesun Kwak PhD
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  1. University of Washington School of Medicine, Seattle, WA

    Mary L. Disis MD

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Kwak, H., Kaufman, H.L. (2006). DNA Vaccines for Cancer Immunotherapy. In: Disis, M.L. (eds) Immunotherapy of Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59745-011-1:087

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