Abstract
It is a widely held belief that alcohol consumption can reduce stress, and individuals commonly use, or say they use, alcohol for this purpose. Stress is therefore thought to be a strong factor in the initiation and maintenance of alcohol consumption, and is considered to be a major contributor to alcohol dependence (Brady & Sonne, 1999; Pohorecky, 1981; Powers & Kutash, 1985). Consequently, the interaction between alcohol and stress has received much attention and interest from the scientific community and the literature on stress and alcohol interactions is extensive (Brady & Sonne, 1999; Pohorecky, 1981, Pohorecky, 1990, Phorecky, 1991; Powers & Kutash, 1985). However, the interaction of alcohol and stress is complex. The effectiveness of alcohol in actually reducing stress appears to depend on both genetic and environmental factors. In addition, alcohol alters the activity of the hormonal stress response system, the hypothalamic-pituitary-adrenal (HPA) axis.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Abrams, D. B., & Niaura, R. S. (1987). Social learning theory. In H. T. Blane & K. E. Leonard (Eds.), Psychological theories of drinking and alcoholism (pp. 131–178). New York: Guilford.
Adinoff, B., Risher-Flowers, D., De Jong, J., Ravitz, B., Bone, G. H., Nutt, D. J., Roehrich, L., Martin, P. R., & Linnoila, M. (1991). Disturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men. American Journal of Psychiatry, 148, 1023–1025.
Angelogianni, P., & Gianoulakis, C. (1989). Prenatal exposure to ethanol alters the ontogeny of the beta-endorphin response to stress. Alcoholism: Clinical and Experimental Research, 13, 564–571.
Baer, J. S., Sampson, P. D., Barr, H. M., Connor, P. D., & Streissguth, A. P. (2003). A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Archives of General Psychiatry, 60, 377–385.
Bond, N. W., & Di Giusto, E. L. (1976). Effects of prenatal alcohol consumption on open-field behaviour and alcohol preference in rats. Psychopharmacologia, 46, 163–165.
Brady, K. T., & Sonne, S. C. (1999). The role of stress in alcohol use, alcoholism treatment, and relapse. Alcohol Research and Health: the Journal of the National Institute on Alcohol Abuse and Alcoholism, 23, 263–271.
Cappell, H. (1975). An evaluation of tension models of alcohol consumption. In R. J. Gibbins, Y. Israel, H. Kalant, R. E. Popham, W. Schmidt, & R. G. Smart (Eds.), Research advances in alcohol and drug problems (Vol. 2, pp. 177–210). New York: John Wiley & Sons.
Cappell, H., & Greeley, J. (1987). Alcohol and tension reduction: An update on research and theory. In H. T. Blake & K. E. Leonard (Eds.), Psychological theories of drinking and alcoholism (pp. 15–54). New York: Guilford.
Cappell, H., & Herman, C. P. (1972). Alcohol and tension reduction: A review. Journal of Studies on Alcohol, 33, 33–64.
Conger, J. J. (1956). Alcoholism: Theory, problem and challenge. II. Reinforcement theory and the dynamics of alcoholism. Quarterly Journal of Studies on Alcohol, 13, 296–305.
Conway, T. L., Vickers Jr., R. R., Ward, H. W., & Rahe, R. H. (1981). Occupational stress and variation in cigarette, coffee, and alcohol consumption. Journal of Health and Social Behavior, 22, 155–165.
Corrigan, E. M. (1985). Gender differences in alcohol and other drug use. Addictive Behaviors, 10, 313–317.
Costa, A., Bono, G., Martignoni, E., Merlo, P., Sances, G., & Nappi, G. (1996). An assessment of hypothalamic-pituitary-adrenal axis functioning in non-depressed, early abstinent alcoholics. Psychoneuroendocrinology, 21, 263–275.
Crabbe, J. C., Belknap, J. K., & Buck, K. J. (1994). Genetic animal models of alcohol and drug abuse. Science, 264, 1715–1723.
Dai, X., Thavundayil, J., & Gianoulakis, C. (2002a). Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history. Alcoholism: Clinical and Experimental Research, 26, 1171–1180.
Dai, X., Thavundayil, J., & Gianoulakis, C. (2002b). Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholism. Neuropsychopharmacology, 27, 442–452.
De Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joels, M. (1998). Brain corticosteroid receptor balance in health and disease. Endocrine Reviews, 19, 269–301.
del Arbol, J. L., Aguirre, J. C., Raya, J., Rico, J., Ruiz-Requena, M. E., & Miranda, M. T. (1995). Plasma concentrations of beta-endorphin, adrenocorticotropic hormone, and cortisol in drinking and abstinent chronic alcoholics. Alcohol, 12, 525–529.
Eguchi, Y. (1969). Interrelationships between the foetal and maternal hypophysial adrenal axes in rats and mice. In E. Bajusz (Ed.), Physiology and pathology of adaptation mechanisms (pp. 3–27). New York: Pergamon.
Ehlers, C. L., Chaplin, R. I., Wall, T. L., Lumeng, L., Li, T. K., Owens, M. J., & Nemeroff, C. B. (1992). Corticotropin releasing factor (CRF): Studies in alcohol preferring and non-preferring rats. Psychopharmacology, 106, 359–364.
Ehrenreich, H., Schuck, J., Stender, N., Pilz, J., Gefeller, O., Schilling, L., Poser, W., & Kaw, S. (1997). Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence. Alcoholism: Clinical and Experimental Research, 21, 1285–1293.
Elton, R. H., Greaves, D. A., Bunger, D. R., & Pyle, T. W. (1976). Drinking patterns of pigtailed macaques. Journal of Studies on Alcohol, 37, 1548–1555.
Fahlke, C., Engel, J. A., Eriksson, C. J., Hard, E., & Soderpalm, B. (1994). Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol, 11, 195–202.
Fahlke, C., Hard, E., & Hansen, S. (1996). Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone. Psychopharmacology, 127, 133–139.
Fahlke, C., Lorenz, J. G., Long, J., Champoux, M., Suomi, S. J., & Higley, J. D. (2000). Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates. Alcoholism: Clinical and Experimental Research, 24, 644–650.
Finn, P. R., & Pihl, R. O. (1988). Risk for alcoholism: A comparison between two different groups of sons of alcoholics on cardiovascular reactivity and sensitivity to alcohol. Alcoholism: Clinical and Experimental Research, 12, 742–747.
Froehlich, J. C., Harts, J., Lumeng, L., & Li, T. K. (1990). Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharmacology, Biochemistry and Behavior, 35, 385–390.
Gianoulakis, C. (1996). Implications of endogenous opioids and dopamine in alcoholism: Human and basic science studies. Alcohol and Alcoholism, 31, 33–42.
Gianoulakis, C. (2001). Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. Journal of Psychiatry and Neuroscience, 26, 304–318.
Gianoulakis, C., Beliveau, D., Angelogianni, P., Meaney, M., Thavundayil, J., Tawar, V., & Dumas, M. (1989). Different pituitary beta-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sciences, 45, 1097–1109.
Gianoulakis, C., Krishnan, B., & Thavundayil, J. (1996). Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism. Archives of General Psychiatry, 53, 250–257.
Gianoulakis, C., Dai, X., & Brown, T. (2003). Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender. Alcoholism Clinical and Experimental Research, 27, 410–423.
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982). Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature, 299, 355–357.
Glavas, M. M., Ellis, L., Yu, W. K., & Weinberg, J. (2000). Corticotropin releasing hormone and vasopressin expression are altered in rats prenatally exposed to ethanol. Alcoholism: Clinical and Experimental Research, 24, 100A.
Goodwin, D. W. (1984). Studies of familial alcoholism: a review. Journal of Clinical Psychiatry, 45, 14–17.
Grahame, N. J. (2000). Selected lines and inbred strains. Tools in the hunt for the genes involved in alcoholism. Alcohol Research and Health: the Journal of the National Institute on Alcohol Abuse and Alcoholism, 24, 159–163.
Greeley, J., & Oei, T. (1999). Alcohol and tension reduction. In K. E. Leonard & H. T. Blane (Eds.), Psychological theories of drinking and alcoholism, 2nd ed. (pp. 14–53). New York: Guilford.
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977). β-Endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science, 197, 1367–1369.
Heath, A. C., & Nelson, E. C. (2002). Effects of the interaction between genotype and environment. Research into the genetic epidemiology of alcohol dependence. Alcohol Research and Health: the Journal of the National Institute on Alcohol Abuse and Alcoholism, 26, 193–201.
Higley, J. D., Hasert, M. F., Suomi, S. J., & Linnoila, M. (1991). Nonhuman primate model of alcohol abuse: Effects of early experience, personality, and stress on alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America, 88, 7261–7265.
Hilton, M. E. (1987). Drinking patterns and drinking problems in 1984: Results from a general population survey. Alcoholism: Clinical and Experimental Research, 11, 167–175.
Holmes, M. C., Antoni, F. A., Aguilera, G., & Catt, K. J. (1986). Magnocellular axons in passage through the median eminence release vasopressin. Nature, 319, 326–329.
Hull, J. G. (1981). A self-awareness model of the causes and effects of alcohol consumption. Journal of Abnormal Psychology, 90, 586–600.
Huot, R. L., Thrivikraman, K. V., Meaney, M. J., & Plotsky, P. M. (2001). Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment. Psychopharmacology, 158, 366–373.
Ida, Y., Tsujimaru, S., Nakamaura, K., Shirao, I., Mukasa, H., Egami, H., & Nakazawa, Y. (1992). Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males. Drug and Alcohol Dependence, 31, 57–64.
Inder, W. J., Joyce, P. R., Wells, J. E., Evans, M. J., Ellis, M. J., Mattioli, L., & Donald, R. A. (1995). The acute effects of oral ethanol on the hypothalamic-pituitary-adrenal axis in normal human subjects. Clinical Endocrinology, 42, 65–71.
Iranmanesh, A., Veldhuis, J. D., Johnson, M. L., & Lizarralde, G. (1989). 24-Hour pulsatile and circadian patterns of cortisol secretion in alcoholic men. Journal of Andrology, 10, 54–63.
Kakihana, R., Butte, J. C., & Moore, J. A. (1980). Endocrine effects of maternal alcoholization: Plasma and brain testosterone, dihydrotestosterone, estradiol, and corticosterone. Alcoholism: Clinical and Experimental Research, 4, 57–61.
Kendler, K. S., Prescott, C. A., Neale, M. C., & Pedersen, N. L. (1997). Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Archives of General Psychiatry, 54, 178–184.
Khachaturian, H., Lewis, M. E., Schafer, M. K. H., & Watson, S. J. (1985). Anatomy of the CNS opioid systems. Trends in Neurosciences, 8, 111–119.
Kim, C. K., Osborn, J. A., & Weinberg, J. (1996). Stress reactivity in fetal alcohol syndrome. In E. Abel (Ed.), Fetal alcohol syndrome: From mechanism to behavior (pp. 215–235). Boca Raton, FL: CRC.
Kim, C. K., Giberson, P. K., Yu, W., Zoeller, R. T., & Weinberg, J. (1999). Effects of prenatal ethanol exposure on hypothalamic-pituitary-adrenal responses to chronic cold stress in rats. Alcoholism: Clinical and Experimental Research, 23, 301–310.
Knych, E. T., & Prohaska, J. R. (1981). Effect of chronic intoxication and naloxone on the ethanol-induced increase in plasma corticosterone. Life Sciences, 28, 1987–1994.
Koob, G. F. (1992). Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends in Pharmacological Sciences, 13, 177–184.
Koob, G. F. (2003). Alcoholism: Allostasis and beyond. Alcoholism: Clinical and Experimental Research, 27, 232–243.
Kraemer, G. W., & McKinney, W. T. (1985). Social separation increases alcohol consumption in rhesus monkeys. Psychopharmacology, 86, 182–189.
Laszlo, F. A., Varga, C., Pavo, I., Gardi, J., Vecsernyes, M., Galfi, M., Morschl, E., Laszlo, F., & Makara, G. B. (2001). Vasopressin pressor receptor-mediated activation of HPA axis by acute ethanol stress in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 280, R458–465.
Lee, S., & Rivier, C. (1996). Gender differences in the effect of prenatal alcohol exposure on the hypothalamic-pituitary-adrenal axis response to immune signals. Psychoneuroendocrinology, 21, 145–155.
Lee, S., Imaki, T., Vale, W., & Rivier, C. (1990). Effect of prenatal exposure to ethanol on the activity of the hypothalamic-pituitary-adrenal axis of the offspring: Importance of the time of exposure to ethanol and possible modulating mechanisms. Molecular and Cellular Neurosciences, 1, 168–177.
Lee, S., Schmidt, D., Tilders, F., Cole, M., Smith, A., & Rivier, C. (2000a). Prolonged exposure to intermittent alcohol vapors blunts hypothalamic responsiveness to immune and non-immune signals. Alcoholism: Clinical and Experimental Research, 24, 110–122.
Lee, S., Schmidt, D., Tilders, F., & Rivier, C. (2000b). Increased activity of the hypothalamic-pituitary-adrenal axis of rats exposed to alcohol in utero: Role of altered pituitary and hypothalamic function. Molecular and Cellular Neurosciences, 16, 515–528.
Lee, S., Schmidt, D., Tilders, F. J. H., & Rivier, C. (2001). Effect of repeated exposure to alcohol on the response of the hypothalamic-pituitary-adrenal axis of the rat: I. Role of changes in hypothalamic neuronal activity. Alcoholism: Clinical and Experimental Research, 25, 98–105.
Leo, J. M., Glavas, M. M., Yu, W. K., Ellis, L., & Weinberg, J. (2002). Prenatal ethanol exposure differentially alters HPA regulation in male and female rats. Society for Neuroscience Abstracts, 32.
Levenson, R. W., Sher, K. J., Grossman, L. M., Newman, J., & Newlin, D. B. (1980). Alcohol and stress response dampening: Pharmacological effects, expectancy, and tension reduction. Journal of Abnormal Psychology, 89, 528–538.
Levenson, R. W., Oyama, O. N., & Meek, P. S. (1987). Greater reinforcement from alcohol for those at risk: parental risk, personality risk, and sex. Journal of Abnormal Psychology, 96, 242–253.
Li, T.-K., Lumeng, L., Doolittle, D. P., McBride, W. J., Murphy, J. M., Froehlich, J. C., & Morzorati, S. (1988). Behavioral and neurochemical associations of alcohol-seeking behavior. In K. Kuriyama, A. Takada, & H. Ishii (Eds.), Biomedical and social aspects of alcohol and alcoholism. (pp. 435–438). Amsterdam: Elsevier.
Lumeng, L., Hawkins, T. D., & Li, T.-K. (1977). New strains of rats with alcohol preference and non-preference. In R. G. Thurman, J. R. Williamson, H. R. Drott, & B. Chance (Eds.), Alcohol and aldehyde metabolizing systems (Vol. 3, pp. 537–544). New York: Academic.
Lynch, W. J., Kushner, M. G., Rawleigh, J. M., Fiszdon, J., & Carroll, M. E. (1999). The effects of restraint stress on voluntary ethanol consumption in rats. Experimental and Clinical Psychopharmacology, 7, 318–323.
Matthews, S. G. (2002). Early programming of the hypothalamic-pituitary-adrenal axis. Trends in Endocrinology and Metabolism, 13, 373–380.
McClearn, G. E., & Rodgers, D. A. (1959). Differences in alcohol preference among inbred strains of mice. Quarterly Journal of Studies on Alcohol, 20, 691–695.
McEwen, B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33–44.
McEwen, B. S., & Stellar, E. (1993). Stress and the individual. Mechanisms leading to disease. Archives of Internal Medicine, 153, 2093–2101.
Miller, P. M., Hersen, M., Eisler, R. M., & Hilsman, G. (1974). Effects of social stress on operant drinking of alcoholics and social drinkers. Behaviour Research and Therapy, 12, 67–72.
Mills, K. C., Bean, J. W., & Hutcheson, J. S. (1977). Shock induced ethanol consumption in rats. Pharmacology, Biochemistry, and Behavior, 6, 107–115.
Myers, R. D., Borg, S., & Mossberg, R. (1986). Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey. Alcohol, 3, 383–388.
Nash, J. F. Jr., & Maickel, R. P. (1985). Stress-induced consumption of ethanol by rats. Life Sciences, 37, 757–765.
Nelson, L. R., Taylor, A. N., Lewis, J. W., Poland, R. E., Redei, E., & Branch, B. J. (1986). Pituitary-adrenal responses to morphine and footshock stress are enhanced following prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 10, 397–402.
O’Doherty, F. (1991). Is drug use a response to stress? Drug and Alcohol Dependence, 29, 97–106.
Ogilvie, K. M., Lee, S., & Rivier, C. (1997a). Role of arginine vasopressin and corticotropin-releasing factor in mediating alcohol-induced adrenocorticotropin and vasopressin secretion in male rats bearing lesions of the paraventricular nuclei. Brain Research, 744, 83–95.
Ogilvie, K., Lee, S., & Rivier, C. (1997b). Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis. Alcoholism: Clinical and Experimental Research, 21, 467–476.
Ogilvie, K. M., & Rivier, C. (1996). Gender difference in alcohol-evoked hypothalamic-pituitary-adrenal activity in the rat: Ontogeny and role of neonatal steroids. Alcoholism: Clinical and Experimental Research, 20, 255–261.
Ogilvie, K. M., & Rivier, C. (1997). Gender difference in hypothalamic-pituitary-adrenal axis response to alcohol in the rat: Activational role of gonadal steroids. Brain Research, 766, 19–28.
O’Malley, S. S. (1996). Opioid antagonists in the treatment of alcohol dependence: Clinical efficacy and prevention of relapse. Alcohol and Alcoholism, 31, 77–81.
O’Regan, D., Welberg, L. L., Holmes, M. C., & Seckl, J. R. (2001). Glucocorticoid programming of pituitary-adrenal function: mechanisms and physiological consequences. Seminars in Neonatology, 6, 319–329.
Pacak, K., & Palkovits, M. (2001). Stressor specificity of central neuroendocrine responses: Implications for stress-related disorders. Endocrine Reviews, 22, 502–548.
Peterson, J. B., & Pihl, R. O., Seguin, J. R., Finn, P. R., & Stewart, S. H. (1993). Heart-rate reactivity and alcohol consumption among sons of male alcoholics and sons of nonalcoholics. Journal of Psychiatry and Neuroscience, 18, 190–198.
Piazza, N. J., Vrbka, J. L., & Yeager, R. D. (1989). Telescoping of alcoholism in women alcoholics. International Journal of the Addictions, 24, 19–28.
Pohorecky, L. A. (1981). The interaction of alcohol and stress: A review. Neuroscience and Biobehavioral Reviews, 5, 209–229.
Pohorecky, L. A. (1990). Interaction of ethanol and stress: Research with experimental animals—an update. Alcohol and Alcoholism, 25, 263–276.
Pohorecky, L. A. (1991). Stress and alcohol interaction: An update of human research. Alcoholism: Clinical and Experimental Research, 15, 438–459.
Pohorecky, L. A., Rassi, E., Weiss, J. M., & Michalak, V. (1980). Biochemical evidence for an interaction of ethanol and stress: Preliminary studies. Alcoholism: Clinical and Experimental Research, 4, 423–426.
Powers, R. J., & Kutash, I. L. (1985). Stress and alcohol. International Journal of the Addictions, 20, 461–482.
Prescott, C. A., & Kendler, K. S. (1999). Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. American Journal of Psychiatry, 156, 34–40.
Raber, J. (1998). Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits. Molecular Neurobiology, 18, 1–22.
Randall, C. L., Roberts, J. S., Del Boca, F. K., Carroll, K. M., Connors, G. J., & Mattson, M. E. (1999). Telescoping of landmark events associated with drinking: A gender comparison. Journal of Studies on Alcohol, 60, 252–260.
Rasmussen, D. D., Boldt, B. M., Bryant, C. A., Mitton, D. R., Larsen, S. A., & Wilkinson, C. W. (2000). Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcoholism: Clinical and Experimental Research, 24, 1836–1849.
Rees, L. H., Besser, G. M., Jeffcoate, W. J., Goldie, D. J., & Marks, V. (1977). Alcohol-induced pseudo-Cushing’s syndrome. Lancet, 1, 726–728.
Rivest, S., & Rivier, C. (1994). Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats. American Journal of Physiology, 266, R553–558.
Rivier, C., Bruhn, T., & Vale, W. (1984). Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: Role of corticotropin-releasing factor (CRF). Journal of Pharmacology and Experimental Therapeutics, 229, 127–131.
Rivier, C., Imaki, T., & Vale, W. (1990). Prolonged exposure to alcohol: Effect on CRF mRNA levels, and CRF-and stress-induced ACTH secretion in the rat. Brain Research, 520, 1–5.
Rivier, C., & Lee, S. (1996). Acute alcohol administration stimulates the activity of hypothalamic neurons that express corticotropin-releasing factor and vasopressin. Brain Research, 726, 1–10.
Rivier, C., Rivier, J., & Lee, S. (1996). Importance of pituitary and brain receptors for corticotrophin-releasing factor in modulating alcohol-induced ACTH secretion in the rat. Brain Research, 721, 83–90.
Rivier, C., & Vale, W. (1988). Interaction between ethanol and stress on ACTH and beta-endorphin secretion. Alcoholism: Clinical and Experimental Research, 12, 206–210.
Robins, L. N., Helzer, J. E., Weissman, M. M., Orvaschel, H., Gruenberg, E., Burke, J. D., & Regier, D. A. (1984). Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry, 41, 949–958.
Roy, A., Mittal, N., Zhang, H., & Pandey, S. C. (2002). Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal. Journal of Pharmacology and Experimental Therapeutics, 301, 774–784.
Sayette, M. A. (1993). An appraisal-disruption model of alcohol’s effects on stress responses in social drinkers. Psychological Bulletin, 114, 459–476.
Sayette, M. A., Breslin, F. C., Wilson, G. T., & Rosenblum, G. D. (1994). Parental history of alcohol abuse and the effects of alcohol and expectations of intoxication on social stress. Journal of Studies on Alcohol, 55, 214–223.
Schuckit, M. A. (1998). Biological, psychological, and environmental predictors of the alcoholism risk: A longitudinal study. Journal of Studies on Alcohol, 59, 485–494.
Schuckit, M. A. (2000). Genetics of the risk for alcoholism. American Journal on Addictions, 9, 103–112.
Schuckit, M. A., Gold, E., & Risch, C. (1987). Plasma cortisol levels following ethanol in sons of alcoholics and controls. Archives of General Psychiatry, 44, 942–945.
Schuckit, M. A., Tsuang, J. W., Anthenelli, R. M., Tipp, J. E., & Nurnberger, J. I. (1996). Alcohol challenges in young men from alcoholic pedigrees and control families: A report from the COGA project. Journal of Studies on Alcohol, 57, 368–377.
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001). Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proceedings of the National Academy of Sciences of the United States of America, 98, 4770–4775.
Selye, H. (1936). A syndrome produced by diverse nocuous agents. Nature, 138, 32.
Selye, H. (1974.) Stress without distress. Toronto: McClelland and Stewart Ltd.
Sher, K. J. (1987). Stress-response dampening. In H. T. Blane & K. E. Leonard (Eds.), Psychological theories of drinking and alcoholism (pp. 131–178). New York: Guilford.
Sher, K. J., & Levenson, R. W. (1982). Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol. Journal of Abnormal Psychology, 91, 350–367.
Sher, K. J., & Walitzer, K. S. (1986). Individual differences in the stress-response-dampening effect on alcohol: A dose-response study. Journal of Abnormal Psychology, 95, 159–167.
Silva, S. M., Paula-Barbosa, M. M., & Madeira, M. D. (2002). Prolonged alcohol intake leads to reversible depression of corticotropin-releasing hormone and vasopressin immunoreactivity and mRNA levels in the parvocellular neurons of the paraventricular nucleus. Brain Research, 954, 82–93.
Spanagel, R. (2000). Recent animal models of alcoholism. Alcohol Research and Health: The Journal of the National Institute on Alcohol Abuse and Alcoholism, 24, 124–131.
Spencer, R. L., & McEwen, B. S. (1990). Adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress. Neuroendocrinology, 52, 481–489.
Steele, C. M., & Josephs, R. A. (1988). Drinking your troubles away II: An attention-allocation model of alcohol’s effect on psychological stress. Journal of Abnormal Psychology, 97, 196–205.
Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In J. Fisher & J. Reason (Eds.), Handbook of life stress, cognition, and health (pp. 629–649). New York: John Wiley & Sons.
Stewart, S. H., Finn, P. R., & Pihl, R. O. (1992). The effects of alcohol on the cardiovascular stress response in men at high risk for alcoholism: A dose response study. Journal of Studies on Alcohol, 53, 499–506.
Stott, D. J., Ball, S. G., Inglis, G. C., Davies, D. L., Fraser, R., Murray, G. D., & McInnes, G. T. (1987). Effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes. Clinical Science, 73, 411–416.
Tabakoff, B., Jafee, R. C., & Ritzmann, R. F. (1978). Corticosterone concentrations in mice during ethanol drinking and withdrawal. Journal of Pharmacy and Pharmacology, 30, 371–374.
Taylor, A. N., Branch, B. J., Kokka, N., & Poland, R. E. (1983). Neonatal and long-term neuroendocrine effects of fetal alcohol exposure. Monographs in Neural Sciences, 9, 140–152.
Taylor, A. N., Branch, B. J., Liu, S. H., & Kokka, N. (1982). Long-term effects of fetal ethanol exposure on pituitary-adrenal response to stress. Pharmacology, Biochemistry, and Behavior, 16, 585–589.
Taylor, A. N., Branch, B. J., Liu, S. H., Wiechmann, A. F., Hill, M. A., & Kokka, N. (1981). Fetal exposure to ethanol enhances pituitary-adrenal and temperature responses to ethanol in adult rats. Alcoholism: Clinical and Experimental Research, 5, 237–246.
Taylor, A. N., Branch, B. J., Nelson, L. R., Lane, L. A., & Poland, R. E. (1986). Prenatal ethanol and ontogeny of pituitary-adrenal responses to ethanol and morphine. Alcohol, 3, 255–259.
Taylor, A. N., Branch, B. J., van Zuylen, J. E., & Redei, E. (1988). Maternal alcohol consumption and stress responsiveness in offspring. In G. P. Chrousos, D. L. Loriaux, & P. W. Gold (Eds.), Mechanisms of physical and emotional stress. Advances in experimental medicine and biology (Vol. 245, pp. 311–317). New York: Plenum.
Timmer, S. G., Veroff, J., & Colten, M. E. (1985). Life stress, helplessness, and the use of alcohol and drugs to cope: An analysis of national survey data. In S. Shiffman & T. Ashby Wills (Eds.), Coping and substance use (pp. 171–199). New York: Academic.
Veldman, R. G., & Meinders, A. E. (1996). On the mechanism of alcohol-induced pseudo-Cushing’s syndrome. Endocrine Reviews, 17, 262–268.
Vescovi, P. P., DiGennaro, C., & Coiro, V. (1997). Hormonal (ACTH, cortisol, beta-endorphin, and metenkephalin) and cardiovascular responses to hyperthermic stress in chronic alcoholics. Alcoholism: Clinical and Experimental Research, 21, 1195–1198.
Volpicelli, J. R. (1987). Uncontrollable events and alcohol drinking. British Journal of Addiction, 82, 381–392.
Waltman, C., Blevins, L. S., Boyd, G., & Wand, G. S. (1993). The effects of mild ethanol intoxication on the hypothalamic-pituitary-adrenal axis in nonalcoholic men. Journal of Clinical Endocrinology and Metabolism, 77, 518–522.
Waltman, C., McCaul, M. E., & Wand, G. S. (1994). Adrenocorticotropin responses following administration of ethanol and ovine corticotropin-releasing hormone in the sons of alcoholics and control subjects. Alcoholism: Clinical and Experimental Research, 18, 826–830.
Wand, G. S. (1993). Alcohol, the hypothalamic-pituitary-adrenal axis, and hormonal tolerance. In S. Zakhari (Ed.), Alcohol and the endocrine system (pp. 251–270). Bethesda, MD: National Institutes of Health.
Wand, G. S., & Dobs, A. S. (1991). Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. Journal of Clinical Endocrinology and Metabolism, 72, 1290–1295.
Wand, G. S., Mangold, D., Ali, M., & Giggey, P. (1999). Adrenocortical responses and family history of alcoholism. Alcoholism: Clinical and Experimental Research, 23, 1185–1190.
Weinberg, J. (1985). Effects of ethanol and maternal nutritional status on fetal development. Alcoholism: Clinical and Experimental Research, 9, 49–55.
Weinberg, J. (1987). Effects of early experience on responsiveness to ethanol: A preliminary report. Physiology and Behavior, 40, 401–406.
Weinberg, J. (1988). Hyperresponsiveness to stress: Differential effects of prenatal ethanol on males and females. Alcoholism: Clinical and Experimental Research, 12, 647–652.
Weinberg, J. (1989). Prenatal ethanol exposure alters adrenocortical development of offspring. Alcoholism: Clinical and Experimental Research, 13, 73–83.
Weinberg, J. (1992). Prenatal ethanol effects: Sex differences in offspring stress responsiveness. Alcohol, 9, 219–223.
Weinberg, J. (1993). Neuroendocrine effects of prenatal alcohol exposure. Annals of the New York Academy of Sciences, 697, 86–96.
Weinberg, J., & Gallo, P. V. (1982). Prenatal ethanol exposure: Pituitary-adrenal activity in pregnant dams and offspring. Neurobehavioral Toxicology and Teratology, 4, 515–520.
Weinberg, J., Taylor, A. N., & Gianoulakis, C. (1996). Fetal ethanol exposure: Hypothalamic-pituitary-adrenal and beta-endorphin responses to repeated stress. Alcoholism: Clinical and Experimental Research, 20, 122–131.
Williams, T. A., Calhoun, G., & Ackoff, R. L. (1982). Stress, alcoholism and personality. Human Relations, 35, 491–510.
Wilson, G. T., Abrams, D. B., & Lipscomb, T. R. (1980). Effects of intoxication levels and drinking pattern on social anxiety in men. Journal of Studies on Alcohol, 41, 250–264.
Zhou, Y., Franck, J., Spangler, R., Maggos, C. E., Ho, A., & Kreek, M. J. (2000). Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily “binge” intragastric alcohol administration. Alcoholism: Clinical and Experimental Research, 24, 1575–1582.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Glavas, M.M., Weinberg, J. (2006). Stress, Alcohol Consumption, and the Hypothalamic-Pituitary-Adrenal Axis. In: Yehuda, S., Mostofsky, D.I. (eds) Nutrients, Stress, and Medical Disorders. Nutrition and Health. Humana Press. https://doi.org/10.1385/1-59259-952-4:165
Download citation
DOI: https://doi.org/10.1385/1-59259-952-4:165
Publisher Name: Humana Press
Print ISBN: 978-1-58829-432-6
Online ISBN: 978-1-59259-952-3
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)