Stress, Glucocorticoids, and the Brain
When deviations in physiological or behavioral parameters exceed a certain threshold, central release of corticotropin-releasing hormone (CRH) from the parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) is triggered. CRH activates, in the specific context of the stressor, the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, which promote a series of physiological and behavioral adaptations in order to reestablish homeostasis (McEwen, 1998). Multiple afferents can activate CRH neurons, each conveying specific stressful information. These afferents can be ascending direct innervations from the brainstem that relay stressors of systemic origin (metabolic demands, fluid loss, pain, inflammation). Sensory cognitive and emotional information also reaches via a complex transsynaptic pathway—the PVN (Herman et al., 2003). The summation of all inputs to the PVN provides an output that can be measured as the threshold for activation of these neurons as well as the rate of onset, magnitude and duration of the response. The type of afferent input additionally determines the composition of the cocktail of adrenocorticotropic hormone (ACTH) secretagogs released with CRH in interaction with other stress hormones (e.g., norepinephrine [NE] and epinephrine [E]) (Goldstein, 2003; Herman et al., 2003; Romero & Sapolsky, 1996). This initial CRH-mediated stress reaction is counterbalanced by the stress-induced elevation in circulating levels of glucocorticoids and by parasympathetic nervous system activity. Recently it has been suggested that the CRH-2 receptor system is prominent in the coordination of these later slow responses, facilitating the recovery of homeostasis (Hsu & Hsueh, 2001; Reul & Holsboer, 2002).
- Stress, Glucocorticoids, and the Brain
- Book Title
- Nutrients, Stress, and Medical Disorders
- Book Part
- pp 111-135
- Print ISBN
- Online ISBN
- Series Title
- Nutrition and Health
- Humana Press
- Copyright Holder
- Humana Press Inc.
- Additional Links
- Industry Sectors
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- Editor Affiliations
- 1. Psychopharmacology Laboratory, Department of Psychology, and The Gonda Research Center, Bar Ilan University
- 2. Department of Psychology, Boston University
- Author Affiliations
- 3. Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
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