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Role of Rafts in Virus Fusion and Budding

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Abstract

The discovery that cell membranes are a mosaic of at least two domains (raft and nonraft) differing in lipid composition has led to an explosion of studies investigating the domain localization of a large number of individual proteins, including proteins involved in the cellular entry and egress of viruses and other pathogens. The driving force behind these studies is the assumption that the partitioning between domains has functional consequences, and will shed light on fundamental processes in cell biology such as signaling, trafficking, macromolecular assembly, regulation of protein interactions, and membrane fission and fusion.

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  1. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD

    Wu Ou & Jonathan Silver

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  1. Wu Ou
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  1. Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD

    Mark P. Mattson

  2. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD

    Mark P. Mattson

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Ou, W., Silver, J. (2005). Role of Rafts in Virus Fusion and Budding. In: Mattson, M.P. (eds) Membrane Microdomain Signaling. Humana Press. https://doi.org/10.1385/1-59259-803-X:127

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